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Biomedical subjects

R E Fechner

Publications and source records attributed to R E Fechner.

At least 163 records · Page 9Linked to original sources
PubMed1977

Influence of oral contraceptives on breast diseases.

Three sources of information are available pertaining to the effect of oral contraceptive hormones on the breast: 1) toxicity experiments in animals; 2) histologic examinations of breast tissue from women taking hormones; and 3) epidemiologic studies of women using hormones. Animals treated with hormones at doses equivalent to the human contraceptive level have not developed cancer of the breast at a greater than expected frequency. Monkeys, the one experimental animal with a reproductive cycle similar to humans, have not developed cancer during long-term hormone administration except for a single animal which likely represents a chance occurrence. In humans, histologic studies of breast tissue have failed to identify abnormalities which could be attributed to hormones with rare exceptions of secretory change indistinguishable from normal lactating breast. Epidemiologic studies have usually shown a decreased frequency of benign breast disease and neither an increase nor a decrease in carcinoma of the breast. The one exception to the latter statement is a possible increased risk of cancer in long-term users who have had previous surgery for benign breast disease.

Adenofibroma↗
PubMed1977

Inverted papilloma of the lacrimal sac, the paranasal sinuses and the cervical region.

A 22-year-old woman presented with a lacrimal sac mass which on biopsy was an inverted papilloma. Two years later an ipsilateral cervical mass was removed, which contained inverted papilloma with a histologically typical pattern. Subsequently, the patient had a medial maxillectomy and remains well 5 years later. The cervical mass may represent inverted papilloma arising in a branchial cleft cyst or it may be a metastasis of benign papilloma to a regional lymph node. This is the second such case reported and the first with substantial followup.

Adult↗
PubMed1977

Benign hepatic lesions and orally administered contraceptives. A report of seven cases and a critical analysis of the literature.

A consecutive series of 12 benign hepatic lesions in women consisted of six cases of focal nodular hyperplasia and six cases of liver cell adenoma. Five of the six women with liver cell adenoma and two of the six with focal nodular hyperplasia had taken orally active contraceptive hormones. These few cases reflect a similar impression gained from a critical analysis of the literature, namely, that focal nodular hyperplasia may be unrelated to the oral administration of contraceptive hormones, whereas the increase in liver cell adenoma reported in recent years is probably related to such therapy. Two women with liver cell adenomas were asymptomatic six and four years after incomplete resection of the tumor. These are the longest intervals thus far reported for uncomplicated survival in incompletely resected liver cell adenoma.

Adult↗
PubMed1977

Necrotizing sialometaplasia: a source of confusion with carcinoma of the palate.

Necrotizing sialometaplasia is a self-healing nonneoplastic disease of the hard and soft palate characterized by one or two deeply excavating ulcers. Histologically, there is necrosis of the mucous cells of the minor salivary gland tissue with partial replacement by squamous epithelium. The deeply situated squamous epithelium intermixed with mucous cells may lead to the erroneous diagnosis of squamous carcinoma or mucoepidermoid carcinoma. The confinement of cytologically benign squamous epithelium to the pre-existing lobular pattern of the salivary gland should permit an accurate histologic diagnosis by biopsy and avert further surgical intervention.

Carcinoma↗
PubMed1977

Evaluation of transbronchial biopsy of the lung.

Transbronchial biopsy of the lung through the fiberoptic bronchoscope is becoming a widely utilized clinical diagnostic technic. The authors reviewed the histologic features of 109 consecutive cases. The primary problem is the small size of the pulmonary tissue samples obtained, which is further compounded by an apparent mechanical inability to enter the biopsy forceps into dense nodules of neoplastic tissue. The diagnosis of carcinoma can best be made by examining the periphery of the cancer for microscopic extension into adjacent pulmonary parenchyma; however, multiple levels of the tissue block are needed to find such foci. A second problem reflects the use of transbronchial biopsy in the early clinical evolution of various infectious diseases in which pulmonary tissue may contain organisms without a fully developed inflammatory response, which would ordinarily provide the clue to the infective agent. The latter problem appears in cases of infections by Pneumocystis carinii. Close cooperation between the clinician and the pathologist is particularly important in all of these clinical situations.

Biopsy↗
PubMed1977

Angiographic and pathologic correlations of hepatic focal nodular hyperplasia.

Focal nodular hyperplasia of the liver has a distinctive gross appearance which includes a central fibrous zone containing vessels with a variety of abnormalities. When focal nodular hyperplasia is visualized arteriographically, an artery enters the lesion, branches, and supplies the mass centrifugally. It is likely that the central fibrous zone is the area from which the these branches originate. Nodular hyperplasia is not a life-threatening lesion, except in women taking oral contraceptives who may have massive hemorrhage. If an asymptomatic lesion of the liver has the distinctive arteriographic centrifugal filling pattern of nodular hyperplasia, resection is not recommended as long as oral contraceptives are not used.

Adolescent↗
PubMed1976

Herpes simplex of the epiglottis.

Herpes simplex commonly affects only the lips and oral cavity. We report a case of a herpetic lesion that appeared to be a carcinoma localized to the epiglottis. The lesion resolved spontaneously within a month. The diagnostic value of viral culture, serological testing, and immunofluorescence, as well as histopathological evaluation is assessed, and a brief review of upper-respiratory tract herpetic disease is presented.

Diagnosis, Differential↗
PubMed1975

Histologic variants of infiltrating lobular carcinoma of the breast.

Thirty-eight breasts with lobular carcinoma in situ and an additional intraductal or infiltrating cancer were studied. Twenty-six of the additional cancers were diagnosed as infiltrating lobular cancer on the basis of a single population of small uniform cells cytologically identical to those in lobular carcinoma in situ. In 20 of these cases the conventional pattern of infiltrating lobular cancer was evident with an individual cell infiltrate with foci of single filing. In the other six there was a confluent arrangement of cells in solid sheets. This pattern has not been previously reported as a pattern of infiltrating lobular cancer. Because of the identical cytologic appearance, we believe it is a variant of infiltraing lobular cancer and should be diagnosed as such.

Breast Neoplasms↗