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Biomedical subjects

R E Fechner

Publications and source records attributed to R E Fechner.

At least 145 records · Page 8Linked to original sources
PubMed1980

Response of mouse kidney to hyperthermia: pathology and temperature--dependence of injury.

Hyperthermia either alone or in combination with radiotherapy and chemotherapy is being used increasingly in the treatment of malignant tumors. This study was designed to evaluate the response of the mouse kidney exposed to a range of hyperthermic temperatures (41 to 45 degrees C) used to induce regression of malignant tumors. Minimal histologic evidence of renal injury occurred in the proximal tubules of the subcapsular region. More extensive damage was characterized by necrosis of tubules and glomeruli in a sharply circumscribed area that involved the lateral subcapsular area where the temperature induced was highest. The tissue histologic reaction was maximal by 24 hours. At temperatures below 41 degrees C no necrosis occurred, whereas at temperatures between 42 and 45 degrees C there was an increasing incidence of necrosis. This increase in tissue reaction above 42 to 43 degrees C is consistent with reported observations from tissue culture and in vivo skin heating experiments, and indicates that normal tissue injury may occur in the same range of temperatures shown to cause regression in malignant tumors.

Animals↗
PubMed1980

Invasive tracheal papillomatosis.

A 27-year-old man had a tracheal resection and laryngectomy for a large papillary mass in the upper trachea which extended between the cartilages into the adjacent soft tissues. Small intracystic papillary structures were formed focally in the invasive component. The epithelium in the invasive elements and the mucosal mass was identical and consisted of cytologically benign squamous, intermediate (transitional), and ciliated cells. Metastasis has not occurred and the patient is well 4 years later. We suggest the term "invasive tracheal papillomatosis" for this infiltrative lesion comprised of multiple types of cytologically benign epithelium.

Adult↗
PubMed1980

Stromal and epithelial changes in the fallopian tube following hormonal therapy.

A 41 year old woman was treated for metrorrhagia with Ovral three times daily for one week, followed by a single daily dose for one month. Hysterectomy and bilateral salpingo-oophorectomy were performed. Histologically the mucosa of both fallopian tubes had large areas of decidual reaction underlying atrophic epithelium. This epithelial stromal dissociation is identical to that seen in the endometria of women taking contraceptive hormones orally, and the hormones are thought to be the cause of the changes in the tubes. These alterations have not been previously described in the salpinx.

Adnexal Diseases↗
PubMed1980

Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes.

Pyogenic granuloma (PG) has a diagnostic, lobular arrangement of capillaries at its base. The lobules consist of discrete clusters of endothelial cells, and the lumina vary from indistinct to prominent. The superficial portions of the lesion may undergo secondary, nonspecific changes including stromal edema, capillary dilation, inflammation, and a granulation tissue reaction. PG has often been equated with these inflammatory changes but objective diagnostic criteria have not been presented. To avoid confusion and focus on the intrinsic nature of PG we suggest the accurate, descriptive term, lobular capillary hemangioma (LCH). A review of 639 vascular lesions of the oral cavity and upper respiratory tract yielded 73 cases with the characteristic features of LCH. The lip was the most common site (38%), followed by the nose (29%), oral mucosa (18%), and tongue (15%). LCH usually presents as a spontaneous, painless, bleeding mass. There is a predilection for males less than 18 years old, females in the reproductive years, and an equal sex distribution beyond 40 years of age. No examples of LCH were found in 68 vascular lesions from the larynx or trachea.

Adolescent↗
PubMed1980

Focal pregnancy-like change of the breast.

Columnar secretory cells similar to those of lactating breast are occasionally seen in otherwise quiescent breast lobules from nonpregnant patients. These foci often contain vacuolated, enlarged, pleomorphic, and hobnail cells that may be confused with neoplastic cells. Nuclear features of malignancy are lacking, however. We present a 47-year-old woman who had focal pregnancy-like change near an excised fibroadenoma and review the literature concerning this finding.

Adenofibroma↗
PubMed1979

Thyroid neoplasia following irradiation for medulloblastoma: report of two cases.

Thyroid neoplasms occurred in two patients 14 and 18 years after treatment with radiation for medulloblastoma. One patient has a papillary cancer and the other patient had multiple adenomas and a Hurthle cell adenoma. In addition, the latter case had foci of hyperplasia plus a microfollicular transformation, which has not been described in association with prior thyroid irradiation. The radiation doses delivered to the thyroid through posterior cervical spinal ports (2000--3000 roentgens) fall within the upper range of radiation dosage associated with induction of neoplastic changes within the thyroid.

Adenoma↗
PubMed1979

Ultrastructure of endometrial stromal foam cells.

An endometrium with cystic-glandular hyperplasia contained large foam cells in the stroma. The majority had ultrastructural characteristics of endometrial stromal cells, although a few were interpreted as macrophages. Endometrial stromal cells that appeared normal by light microscopy contained varying quantities of lipid on ultrastructural examination, and differed from the predominate type of foam cell only by having less cytoplasmic volume and maintaining an elongated shape. Cells intermediate in size and shape between normal stromal cells and foam cells further substantiated the origin of most of the foam cells from endometrial stroma.

Aged↗
PubMed1979

The juxtaoral organ of Chievitz.

Juxtaroral organs were found in 14 of 25 consecutive autopsies in adults who did not have carcinoma or other lesions of the oral mucosa. Nearly all of the epithelium was squamous-like, but an occasional lumen was present, lined with cuboidal cells. Small nerves were intimately associated with the epithelial component. Awareness of this normal structure may be crucial in preventing unnecessarily extensive surgery should it be misinterpreted as perineural invasion by carcinoma.

Adult↗
PubMed1978

Multiple epiglottic cysts.

A 66-year-old man had five cystic lesions of the epiglottis, which were discovered at autopsy. He had complained of hoarseness and dysphagia, but no laryngeal examination was performed because of his terminal condition due to widespread adenocarcinoma that did not involve the larynx. To our knowledge, this is the fourth reported case of multiple laryngeal ductal cysts. To develop a concept of the pathogenesis of these cysts, the normal salivary gland-duct epithelial histologic characteristics were studied in 17 epiglottises that were obtained from children and adults at autopsy. We conclude that the cysts arise from the collecting ducts rather than the smaller interlobular or intralobular ducts.

Adenocarcinoma↗
PubMed1978

Clinical implications of a "nonspecific" transbronchial biopsy.

The diagnostic accuracy of transbronchial biopsy via fiberoptic bronchoscope was reviewed in 127 noncritically ill patients. Biopsy results were analyzed according to whether a "specific" pathologic diagnosis of neoplasm, granuloma or pneumonia, or a "nonspecific" diagnosis of inflammation, fibrosis or normal lung was made. The clinical significance of a "nonspecific" biospy specimen was evaluated by clinical follow-up of at least 12 months (mean 15 months) and by grouping patients according to the type of abnormality found on chest roentgenography. Clinical follow-up was available in 119 of these patients. The over-all "specific" diagnostic yield for biopsy with secretions was 49 per cent, with transbronchial biopsy being the sole means of specific diagnosis in 14 per cent of the patients with a peripheral mass lesion, in 18 per cent of the patients with localized infiltrative processes and in 52 per cent of the patients with diffuse infiltrative processes. In 64 (52 per cent) patients both biopsy specimens and secretions were diagnostically nonspecific. In 16 (77 per cent) patients with peripheral mass lesions but nonspecific biopsy findings and secretions, neoplasm was diagnosed by more invasive procedures. However, 22 (91 per cent) patients with localized and 12 (75 per cent) patients with diffuse infiltrative processes had benign clinical follow-up suggesting that open lung biopsy in such patients should be reserved for patients with obvious clinical or roentgenographic evidence of deterioration.

Biopsy↗
PubMed1978

Atypical lobular and papillary lesions of the breast: a follow-up study of 30 cases.

Sections from 879 consecutive breast biopsies performed for clinically and grossly benign disease between 1962 and 1966 were reviewed. Twenty-four cases of undiagnosed lobular carcinoma in situ or atypical lobular hyperplasia and six cases of intraductal papillary carcinoma were found. Only one patient later developed invasive carcinoma, an infiltrating lobular carcinoma in the ipsilateral breast, which was diagnosed seven years after the biopsy containing lobular carcinoma in situ. Invasive cancers have not been found in other patients who have a median follow-up period of eight years.

Adult↗