Search PubMed⌕ Search

Biomedical subjects

R Drut

Publications and source records attributed to R Drut.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Solitary unilocular cyst of the lung with features of persistent interstitial pulmonary emphysema: report of four cases.

Neonatal interstitial pulmonary emphysema (IPE) is a well-characterized lesion usually presenting in preterm newborns as a complication of respiratory distress syndrome and/or assisted ventilation. Occasionally, IPE may occur spontaneously in infants with no underlying pulmonary disease. Persistence of IPE (PIPE) may be diffuse or localized. Localized PIPE usually presents as multiple cysts 0.3 to 3 cm in one or more lobes of the lung. In this report, we describe four cases of unilocular large cysts (up to 5 cm in diameter) partially lined by uni- and multinucleated histiocytes in a foreign body type reaction and showing gas dissection of the surrounding parenchyma (present in case 1). These histological features favored the diagnosis of PIPE and the cases were interpreted as such, since no other clear-cut diagnosis could be defined. However, because the lesion was limited to one lobe, and the children were full term, asymptomatic at birth and without history of respiratory distress or assisted ventilation, differential diagnosis with other pulmonary cystic lesions of infancy is mandated.

Child, Preschool↗
PubMedDate not supplied

Persistent interstitial pulmonary emphysema-like cyst associated with metastatic synovial sarcoma.

Interstitial pulmonary emphysema is characterized by the presence of gas dissecting the interstitial tissues of the lung. Clinically, it may be acute or persistent, and the latter can be further categorized as localized or diffuse. Usually, it appears in preterm neonates with a history of assisted ventilation or respiratory distress. Although far from frequent, the localized variety of persistent interstitial pulmonary emphysema (PIPE) can develop spontaneously in full-term babies or infants without any obvious underlying pulmonary disease. Histologically, PIPE is characterized by the presence of uni- and multinucleated histiocytes lining the inner surface of the cysts. In this report, we describe a 15-year-old male with synovial sarcoma (SS) of the right ankle diagnosed 4 years previously who developed pulmonary metastasis, one of which presented cystic changes with features of PIPE.

Adolescent↗
PubMedDate not supplied

Human papillomavirus is present in some cases of childhood penile lichen sclerosus: an in situ hybridization and SP-PCR study.

Lichen sclerosus (LS) is a skin disease that may affect both sexes at all ages and at any site. Its etiology remains unknown. The observation of focal koilocytotic-like changes in the stratum malpighii in prepuce samples of LS in children prompted us to investigate the presence of HPV-DNA. Twenty-three paraffin-embedded samples of LS lesions from children aged 4 to 14 years were studied using nested-PCR and in situ hybridization (ISH). Twelve out of 23 cases amplified HPV-DNA (8 cases corresponded to HPV-DNA type 6; 2 cases each to HPV-DNA types 16 and 18). ISH detected HPV sequences in the nuclei of koilocytotic and some parakeratotic cells in 13 cases (9/13 also HPV-DNA positive by PCR). Our results demonstrated the presence of HPV-DNA in roughly 70% of cases of LS of the prepuce in children. We highlight the observation of koilocytotic-like changes in the prepuce and its association with HPV. The possible pathogenetic significance between the virus and the lesion is not settled.

Adolescent↗
PubMedDate not supplied

Congenital hemangioma with milialike structures: a case report.

A 4-month-old infant had two 3 cm x 4 cm hemangiomatous lesions on the scalp and back, present since birth, which contained peculiar white-yellowish small nodules. Histologically the lesions proved to have a hemangiomatous (capillary-type) component together with small keratin-containing epidermal cysts (milia-like) which progressively extruded their contents. The lesions also contained embryonic-like hair structures. The hemangiomas resolved spontaneously. We were unable to find any reference in the literature describing this peculiar combination of features.

Back↗
PubMedDate not supplied

Image analysis of nucleomegalic cells in Chagas' disease placentitis.

Villous stroma nucleomegalic cells harbouring intracytoplasmic parasites are an unusual finding which appears to be restricted to Chagas' disease placentitis. Ploidy analysis of these cells in two cases (twelve nuclei in Case 1 and 26 in Case 2) showed these nuclei to contain quantitatively abnormal DNA. Only a few were diploid, the rest proving to be tetraploid, hypertetraploid and even aneuploid. Little is known about the pathogenesis of these macronuclei. However, since these cells contain large numbers of parasites it is possible that a parasite-induced derangement of the cell cycle at G2 phase may be operative.

Cell Nucleus↗
PubMedDate not supplied

Human papillomavirus (HPV)-associated neonatal giant cell hepatitis (NGCH).

Neonatal giant cell hepatitis (NGCH) is a clinicopathological syndrome that has been related to perinatal infections and metabolic disorders. In a great number of cases no apparent etiology has been found. To characterize the possible relationship between human papillomavirus (HPV) and idiopathic NGCH (INGCH) we analyzed paraffin-embedded hepatic biopsies from seven cases of INGCH for the presence of both HPV and cytomegalovirus (CMV) DNA. Clinically, jaundice, detected within the first 3 days of life (except in one case), and raised levels of serum transaminases and bilirubin, mainly the direct fraction, were recorded in all. Follow-up of six patients revealed complete recovery. In a "blind" experiment, samples were studied along with appropriate controls [2 cases of CMV hepatitis, one case of postinfantile GCH, 12 cases of juvenile laryngeal papillomatosis (JLP), and 5 normal neonatal liver samples] by polymerase chain reaction (PCR). All DNA samples from INGCH consistently showed positive HPV DNA amplification. This was also found in the samples from postinfantile GCH and JLP. In addition, a second biopsy performed 11 months later in one of the cases of INGCH revealed scattered multinucleated hepatocytes and was still positive for HPV DNA. CMV-DNA was detected only in the cases of CMV hepatitis. All five normal livers were negative for HPV and CMV-DNA. These data seem to indicate that HPV may be closely related to a subset of "idiopathic" NGCH with good outcome.

DNA, Viral↗
PubMedDate not supplied

Disseminated cutaneous eruption after BCG vaccination.

We present nine infants (3 to 10 months of age) with numerous small, papular, papular-lichenoid, and papulo-pustular lesions predominantly on the upper and lower limbs associated with local (axillary) lymphadenopathy which appeared after BCG vaccination. Histopathology of the lesions showed small tuberculoid granulomas mainly in the papillary dermis. The presence of BCG bacillus was demonstrated in five out of seven samples from the lymph nodes after culture and in one skin biopsy specimen. All cases, whether treated or not, evolved to complete resolution of the skin lesions. We believe that this peculiar association results from hematogenous spread of the bacillus, which regresses after an adequate immune system reaction.

BCG Vaccine↗
PubMedDate not supplied

Fox-Fordyce disease in two prepubertal girls: histopathologic demonstration of eccrine sweat gland involvement.

This report presents two prepubertal girls with Fox-Fordyce disease. The pruritic papules extensively affected the areas where apocrine glands are distributed (axillae, periareolar and intermammary zones, pubes, infraumbilical midline), and also extended to the neck and face near the external angle of the eyes in one child. Analyses of several biopsy specimens showed that the main lesion was a spongiotic vesicle containing inflammatory cells and keratinocytes affecting the hair infundibula and acrosyringia, together, with hyperkeratosis of both adnexa. The cause of the disease remains elusive, but the microscopic findings may explain the good results obtained with keratolytic agents.

Abdomen↗
PubMedDate not supplied

Pleomorphic xanthoastrocytoma: a report of two cases.

We report two cases of a recently isolated variety of astrocytoma, pleomorphic xanthoastrocytoma, affecting the cerebral cortex and meninges of children and young adults. The first tumor was localized in the left frontal lobe of a 9-year-old girl. The second appeared in the right parietal lobe of a 14-year-old girl. Both tumors displayed a pleomorphic cellular proliferation, with spindle-shaped and bizarre multinucleated giant cells, some positive for neutral lipids, with a prominent reticulin network and areas highly suggestive of malignant fibrohistiocytomas (fibroxanthosarcomas). The glial fibrillary acidic protein was demonstrated by the immunoperoxidase method in the cytoplasm of the giant and the spindle cells. Ultrastructural studies confirmed the glial nature of the tumor. This type of tumor seems to carry a much better prognosis than other tumors from which it has to be separated, e.g., glioblastoma and meningeal sarcomas.

Adolescent↗
PubMedDate not supplied

Nodular regenerative hyperplasia of fetal liver: a report of two cases.

Nodular regenerative hyperplasia in the liver is characterized by diffuse nodularity of the organ secondary to regenerative hepatocellular activity. This alteration is rare in infants and children. We present two cases of nodular regenerative hyperplasia found in fetuses that exhibited several other malformations, sirenomelia and features of schisis association in one and Poland's sequence in the other.

Abnormalities, Multiple↗
PubMedDate not supplied

Angiofollicular lymph node transformation in Hodgkin's lymphoma.

We present four examples of lymph nodes that have Hodgkin's disease between nodules of angiofollicular hyperplasia, three hyaline-vascular and one plasma cell in type, suggesting the concurrence of the lymphoma with Castleman's disease. Angiofollicular hyperplasia is claimed to be an immune derangement, and its presence in Hodgkin's disease may represent such a situation.

Biopsy↗
PubMedDate not supplied

Mature presacral sacrococcygeal teratoma associated with a sacral "epignathus".

We report an example of sacrococcygeal teratoma presenting as a "supernumerary limb" in the left gluteal area with a rudimentary hemipelvis, femur, tibia, fibula, and tarsal bones. This monocephalus tripus dibrachius-appearing complex with associated with a deep seated but separate pararectal mature teratoma. This combination of a well-developed external limb with a deep but separate teratoma has been described.

Bone Neoplasms↗
PubMedDate not supplied

Mesangiolytic poststreptococcal glomerulonephritis.

We describe two children with poststreptococcal glomerulonephritis associated prolonged oligoanuria (12, 13 days). Kidney biopsies at 10 and 6 days, respectively, revealed acute glomerulonephritis with prominent mesangiolysis. Both patients recovered uneventfully. It is proposed that damage to the mesangium accounts for the clinical course.

Anuria↗
PubMedDate not supplied

Hepatic hemangioendotheliomas, placental chorioangiomas, and dysmorphic kidneys in Beckwith-Wiedemann syndrome.

A 4-month-old female, birth weight 3150 g, had a history of maternal eclampsia, multiple placental chorioangiomas, and persistent neonatal hypoglycemia. Macroglossia and enlarged kidneys were recorded. Autopsy revealed multiple hepatic hemangioendotheliomas (type 1), massive cardiomegaly, and bilateral nephromegaly. Both kidneys were lobulated with active glomerulogenesis and clusters of immature tubules and foci of dysplastic medullary ducts. The features suggest that the nephrogenesis was secondary to the persistence of actively branching nephron-inducing ducts. Nodular hyperplasia of the adrenal cortex (adrenoblastomatosis) was present. This report expands the list of tumors to be found in Beckwith-Wiedemann syndrome (BWS).

Adolescent↗