Mesothelioma: ignorance is not bliss.
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Antineoplastic Agents↗
Biomedical subjects
R D Snyder
Publications and source records attributed to R D Snyder.
Late EEG findings and clinical status after organic mercury poisoning.
The EEGs of four siblings with organic mercury poisoning were recorded. The series of EEGs spanned two to eight years. Additional EEGs were obtained from an asymptomatic family member (the mother) who initially had elevated mercury levels. Various types of abnormalities were noted in the tracings of the siblings, including epileptiform features and disturbances of background rhythms. The mother's EEGs were normal. The degree of EEG change reflected the clinical state. In the two cases in which seizures were present, epileptiform activity was seen. Both clinical severity and EEG abnormalities may correlate with age.
Adolescent↗
Topographic mapping in childhood developmental dyslexia.
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Brain Mapping↗
Isolation and characterization of repair-deficient mutants of Drosophila melanogaster.
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Animals↗
Computed tomography in childhood bacterial meningitis.
Computed tomography has been applied to childhood bacterial meningitis in an attempt to analyze the structural basis for neurologic complications. The CT findings in meningitis patients include acute cerebral swelling; moderate widening of basal cisterns, interhemispheric fissue, and subarachnoid convexity space; ventricular widening; subdural collection; focal cortical necrosis; cerebral infarcts; contrast enhancing basal meninges, ependymitis, and generalized cerebral atrophy. Bacterial meningitis in childhood is more than an inflammation of the subarachnoid space. It is a disease process which often exerts a profound effect on the brain parenchyma.
Brain↗
Clinical trials in cancer medicine.
The need for improvement in the results of all types of cancer treatment must be apparent to any practitioner who sees cancer patients. A number of clinical trials are in progress in this country to evaluate various cancer treatments, especially those using drugs. The purpose of this paper is to inform family physicians about the nature of some of these trials, and to provide some information about the drugs being investigated.
Adult↗
Adenocarcinoma of unknown primary site: a clinico-pathological study.
An analysis of the clinico-pathological findings in 49 patients with adenocarcinoma of unknown primary origin indicates a short survival time. No factors were identified that influenced survival. Thromboembolic episodes and second primary tumors commonly complicate the clinical course. Metastases in widespread organs are common autopsy findings. Immunological mechanisms may explain these findings.
Abdominal Neoplasms↗
Adrenoleukodystrophy and adrenomyeloneuropathy associated with partial adrenal insufficiency in three generations of a kindred.
Four cases of adrenoleukodystrophy (ALD) and one case of adrenomyeloneuropathy (AMN) have developed in a kindred over three generations demonstrating that AMN is a clinical variant of ALD. Pituitary-adrenal function studies were performed in 10 family members, including two affected males and four females identified as carriers of ALD/AMN. No pituitary-adrenal abnormality was found in the carriers. However, basal morning plasma adrenocorticotropic hormone (ACTH) levels were markedly elevated in the two males with ALD and AMN, despite the fact that they had no clinical signs of adrenal insufficiency and that morning plasma cortisol levels and their response to maximal exogenous ACTH stimulation appeared to be normal. In addition, the integrated 24-hour response to the administration were also subnormal in these two cases. Thus, people with ALD and AMN may have subclinical partial adrenocrotical insufficiency. No other endocrinologic dysfunction was identified.
Adolescent↗
Benign "subdural" collections.
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Body Fluids↗
Some aspects of the development of methotrexate therapy.
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Drug Administration Schedule↗
The right not to read.
Skill in reading is desirable. However, the importance of reading may be overemphasized in schools. Reading skills are determined relatively and not absolutely. Thus, relatively poor readers will persist. Schools cannot eradicate individual differences. Biological makeup and societal pressures are the important factors in determining reading skill. Present methods of reading remediation are of questionable efficacy and are traumatic to some children. Time with its associated normal development succeeds in remediating the majority of children with dyslexia. Most poor readers eventually attain reading levels that enable them to comprehend the types of printed materials commonly encountered. If a child finds reading difficult or distasteful, that child should be encouraged to read but should have the right not to be forced to read.
Achievement↗
The follow-up CT scan in childhood meningitis.
CT in childhood bacterial meningitis has indicated that bacterial meningitis is more than an inflammation of the subarachnoid space; it is a disease process which often exerts a profound effect on the brain parenchyma. In some cases ventricular widening may be a reflection of loss of brain substance rather than increased intracranial pressure. A vasculitis may occur in cerebral vessels with consequent ischemic infarct. The abnormalities found on CT during the acute illness are frequently persistent.
Age Factors↗
Corticosteroids for asthma during pregnancy.
This is a retrospective evaluation of 36 pregnant patients who required corticosteroids for control of their asthma. In view of the lack of maternal or infant abnormalities it is felt that corticosteroids should not be withheld from pregnant patients when required.
Asthma↗
Histiocytic lymphoma in the brain as the only manifestation of relapse following remission maintainance with BCG immunotherapy.
This report describes an unusual case of lymphoma which, after 54 months of complete remission induced with chemotherapy and maintained with BCG immunotherapy, relapsed in the brain alone. It is possible that the immunotherapy led to this pattern of relapse: this is supported by several other studies. The difficulty in diagnosing brain lymphoma is emphasized.
BCG Vaccine↗