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Biomedical subjects

R D Cartwright

Publications and source records attributed to R D Cartwright.

At least 19 recordsLinked to original sources
PubMed2000

Affect and cognition in dreams: a critique of the cognitive role in adaptive dream functioning and support for associative models.

Dream affect and cognition are examined in a 4-month longitudinal study of depressed, recently divorced subjects. Several measures of cognition in dream reports were used to determine whether remitting subjects were more likely to utilize certain cognitive strategies than nonremitters. No differences were found in the cognition between those who were remitting and nonremitting subjects. Levels of cognition in dreaming were directly related to the emotional intensity of the dreams across all subjects. In subjects with higher depression scores (Beck Depression Inventory > 20), depression levels were inversely related to both dream affect and cognition. It is argued that cognition plays a secondary role in dream production. A modification of David Foulkes's model of dreaming is proposed, in which emotional intensity drives associative processes, which in turn require more elaborate cognitive devices to relate diverse activated mnemonic units.

Adaptation, Psychological↗
PubMed1999

Mycotoxin production by Fusarium proliferatum isolates from rice with Fusarium sheath rot disease.

Twenty samples of unpolished (rough) rice collected in Arkansas and Texas during the 1995 harvesting season from fields exhibiting Fusarium sheath rot disease or panicle blight were previously shown to include 8 samples positive for fumonisin B1 (FB1) in the range 2.2-5.2 ppm, and moniliformin (MON), but no beauvericin (BEA), deoxynivalenol, its derivatives or zearalenone were detected. Fifteen cultures of F. proliferatum were established from the 20 rough rice samples. Single spore isolates of each culture were grown on rice and tested for the production of fumonisins (FB1, FB2, FB3, etc.), MON and BEA. All 15 isolates produced FB1, FB2, MON and BEA in culture on rice. No deoxynivalenol, its derivatives or zearalenone were detected. Seven cultures produced FB1 at > 50 ppm (range 80-230 ppm), with the rest producing FB1 in the range 14-43 ppm. FB2 was produced in the range 5-47 ppm, and those cultures which produced the most FB1 also produced the most FB2. Of the 15 cultures producing MON, 11 produced it at > 100 ppm in the range 188-6018 ppm, with the rest producing in the range 7-64 ppm. BEA was produced in the range 109-1350 ppm. Other derivatives of fumonisins, including FA1, FA2 and partially hydrolyzed FB1, as well as several unknown metabolites including a compound with MW 414, were identified in culture extracts by continuous flow fast atom bombardment with ion spray mass spectrometry (CF/FAB/MS). Further study is needed to identify the factors that control production of FB1, MON and BEA by F. proliferatum in culture and in field samples.

Anti-Bacterial Agents↗
PubMed1997

Comparison of MMPI profiles in medically and psychologically based insomnias.

The MMPI performance of two sub-groups of chronic insomniac patients was compared to determine if patients with psychologically based insomnia (Group 1) differed from those with medically based insomnia (Group 2). This was done to establish whether etiology of insomnia had an impact on the psychological picture. We postulated that Group 1 would show a higher overall incidence of psychopathology, particularly on scales suggesting internalization of distress. Surprisingly, the results revealed no significant differences between the groups with respect to these questions. When the two diagnostic groups were combined, the sample as a whole was characterized by a high overall prevalence of psychopathology. As many as 79.3% of the MMPI records contained one or more clinical scales in the pathological range. Depression was a prominent feature. Our findings emphasize the importance of not assuming that a patient with an organically-based insomnia (e.g. due to sleep apnea, etc.) is free of psychological disturbance. This, in turn, underscores the need for a psychological evaluation as a routine part of the diagnostic work-up of all insomniac patients, regardless of the etiology of their disorder.

Adult↗
PubMed1994

Early REM sleep: a compensatory change in depression?

To test for a possible mood-regulatory function of dreaming, the dream reports of 61 subjects undergoing divorce were scored for their dream-like quality (DLQ), and a difference score (DLQd) was computed between the content of rapid eye movement (REM) period 1 and the mean of the subsequent dreams of the night. Subjects with reduced latency to the first REM period had enhanced first dream DLQ scores in relation to the mean of later dreams (DLQd+ score). Those with DLQd+ had significantly higher scores on the Beck Depression Inventory (BDI). Depressed subjects with DLQd+ showed significantly lower mean BDI scores at followup assessment. Implications for a psychological function of dreaming are discussed.

Adult↗
PubMed1993

The contribution of dream masochism to the sex ratio difference in major depression.

Twenty-five women and twenty-one men undergoing divorce had three laboratory nights of sleep on two occasions 1 year apart. On the third night, dream reports were elicited from subjects for each period of rapid eye movement (REM) sleep. Three groups differing on dream "masochism" were compared on personality, sex role, and social adjustment. Women "masochistic" dreamers had significantly higher scores on a scale of negative aspects of traditional feminine sex role identity than men or women without such dreams. They also showed less improvement at followup and had more need for emotional support. Dream masochism may be a continuing cognitive characteristic that contributes to the vulnerability of women to major depression.

Adaptation, Psychological↗
PubMed1992

Intrathecal baclofen. Effects on nocturnal leg muscle spasticity.

Electromyographic activity was recorded from tibialis anterior during nocturnal polysomnography in six patients with severe spasticity of spinal origin. The patients had a baclofen reservoir system implanted subcutaneously into their lumbar subarachnoid space and were studied for two nights in a double-blind, placebo controlled, crossover design. Tibialis anterior electromyographic activity per hour of sleep was reduced on the night of baclofen infusion. In particular, less electromyographic activity occurred after arousal from sleep.

Adult↗
PubMed1991

Adjustment disorders of sleep: the sleep effects of a major stressful event and its resolution.

Seventy volunteers had 3 nights of sleep recordings during a period of marital separation, and 61 returned for repeat studies 1 year later. At that time, the divorce was final for 42. Forty of the volunteers were depressed when first screened, and 30 were not. Initially all those undergoing marital separation had less delta sleep than an age-matched married comparison sample. Delta increased at followup for those whose divorce was completed. Rapid eye movement (REM) latency was reduced and REM percent was elevated only in the depressed. Among the not depressed, those whose divorces remained incomplete at the followup had lower delta, higher REM percent, and shorter REM latency than did those whose divorces were finalized. This suggests that prolonged emotional stress may put these subjects at some risk for a mood disorder.

Adaptation, Psychological↗
PubMed1991

The effects of sleep posture and sleep stage on apnea frequency.

The Apnea Plus Hypopnea Index (A + HI) of 60 male positional sleep apneics was analyzed by sleep stage to determine if positional differences are limited to NREM sleep. Differences in apnea severity by sleep position were found to persist in REM sleep and to be of equal extent to those differences found in NREM sleep, despite the fact that there is also a significant increase in the frequency of apneic events associated with REM sleep. The positional effect persists in REM sleep, making treatments to control sleep posture a viable option.

Adult↗
PubMed1991

REM latency and the recovery from depression: getting over divorce.

OBJECTIVE: The authors' goal was to address five questions: 1) What is the frequency of early REM sleep in subjects in the process of divorce who meet diagnostic criteria for major depressive disorder? 2) What is the frequency of this sign in subjects in the process of divorce who are not depressed? 3) How often does this sign persist following remission of depressive symptoms? 4) What is the predictive value of early REM sleep among depressed subjects for later adjustment to the process of divorce? and 5) What is the role of a family history of depression or alcoholism in the presence and persistence of early REM sleep? METHOD: Two hundred fourteen volunteers undergoing marital separation were recruited; 70 of these subjects were selected for a 3-night sleep study. Forty of the 70 subjects met criteria for depression and 30 did not; 61 (87%) returned for repeat studies 1 year later. RESULTS: Fifteen (38%) of the 40 depressed subjects had short REM latency. Seven of these continued to have short REM latency 1 year later, but none of these met the criteria for depression at that time. A higher proportion of these subjects had made a good adjustment to their new life than did depressed subjects whose initial and follow-up REM latencies fell within the normal range. CONCLUSIONS: These data suggest that depressed individuals with normal REM latency may need more aggressive treatment intervention.

Adult↗
PubMed1991

Nonpharmacologic treatment of periodic leg movements in sleep.

The effects of a 30-minute stimulation of the dorsiflexors of the feet and toes before bedtime were investigated in eight patients with periodic leg movements in sleep (PLMS). None were taking medications at the time of the investigation. All subjects were treated with the EMS-250 Neuromuscular Stimulator, which has a maximum output per channel of 1.5mA and a frequency of 47Hz. Stimuli were delivered via a pulse train (on for 1.5sec and off for 1.8sec). A single all-night polysomnogram after this stimulation showed that all patients responded to stimulation, with reduction of leg movements from an average pretreatment PLMS index of 44.6 per hour to a posttreatment PLMS index of 14 per hour (p less than .01). Nocturnal leg movements were primarily reduced during the non-REM sleep. Multiple indices of sleep continuity did not change significantly, although there was a trend toward better sleep consolidation.

Adult↗
PubMed1987

Silent partners: the wives of sleep apneic patients.

The wives of 10 male patients being treated for sleep apnea, obstructive type, were interviewed and given the Social Adjustment Scale (SAS) and Marital Satisfaction Inventory (MSI). The patients also completed an SAS and a Minnesota Multiphasic Personality Inventory (MMPI). These data were compared with those from a sample of divorced patients from the same pool. The married patients were significantly more depressed and socially isolated than were those divorced. Both marital partners showed poor adjustment in the Marital and Social/Leisure areas, and patients also showed poor adjustment in their Parental Role. Marriages do not necessarily represent social support but appear to be an added burden for sleep apneic patients.

Adult↗
PubMed1985

Predicting response to the tongue retaining device for sleep apnea syndrome.

Factors associated with increased severity of sleep apnea; obesity, the supine sleep posture, and age, were tested for their association with the effectiveness of the Tongue Retaining Device (TRD) for the control of the apneic events in a group of 16 male patients. Sixty-nine percent of the patients (11 of 16) were successful with this treatment. The strongest predictor of this success was the presence of an increased severity associated with the supine sleep posture. Patients with substantial worsening of apnea index while in the supine sleep position were more responsive to the TRD than those who were equally affected in both sleep positions. A discriminant function analysis that entered age, obesity, and the ratio of apneas per hour in side v back sleep posture correctly classified the success of patients' response to this treatment.

Adult↗
PubMed1985

Sleep position training as treatment for sleep apnea syndrome: a preliminary study.

Ten male patients selected as having sleep apnea predominantly of the obstructive type associated with the supine sleep position on their evaluation night were trained for 1 additional night to avoid the back sleep position by wearing a gravity-activated position monitor/alarm on the chest. This device emitted an auditory signal if the patient remained supine for more than 15 s. The number of apneic events was significantly reduced, as were the number of episodes of significant O2 desaturation. While wearing the alarm, the apnea index of seven patients remained within or near normal limits. On a follow-up night, with only instructions to maintain the lateral decubitus posture, five patients remained significantly improved. Sleep position training may be appropriate as a single or interim treatment for a significant number of sleep apnea patients who have position-related obstruction.

Adult↗
PubMed1985

Obstructive sleep apnea: variations in surgical management.

Forty patients with obstructive sleep apnea (OSA) were either treated by submucous resection, alone or by palatopharyngoplasty (PPP). Before surgery, each patient underwent a thorough sleep evaluation for the diagnosis of OSA. Of the 23 patients treated by submucous resection alone, eight had more than a 50% reduction in their apnea index and were considered successfully treated. Of the remaining 15, ten received a supplemental tongue retaining device (TRD). Five of the ten were markedly improved. The overall success rate in this group was 57%. Of the 17 patients treated by submucous resection and PPP, ten were treated successfully. Six of the remaining seven patients were subsequently treated with a TRD, which was successful in four. The overall success rate in this group was 82%.

Airway Obstruction↗
PubMed1984

Dream dimension differences during a life change.

Dreams reported from laboratory awakening of stably married women differed from those of women undergoing divorce: The former dreamed of the experiment; the latter had more threat themes. Those coping well during the divorce had more positive motives in the last dream than those who were depressed. Dreams of the nondepressed divorcées increased in anxiety from first to last dream report, whereas those of the depressed increased in masochism. Affiliation motives were common in dreams of the married subjects, while harm avoidance predominated in the divorcées' dreams. Nurturance and abasement were also common needs in the dreams of the depressed sample.

Adaptation, Psychological↗
PubMed1984

Broken dreams: a study of the effects of divorce and depression on dream content.

To investigate the dream characteristics associated with a major life change, 29 women (ages 30-55) undergoing divorce were studied six nights in a sleep laboratory. The group was stratified on a self-report depression scale (the Beck Depression Inventory) into a depressed (N = 19, mean = 23.2) and nondepressed (N = 10, mean = 8.2) group and compared to a nondepressed married group who had never considered divorce. The dreams of those divorcing without major mood upset were longer and dealt with a wider time frame than those of the other two groups. They also dealt with marital status issues which were absent in the dreams of the depressed group. On follow-up those who had been depressed showed positive dream changes in mood, dreamlike quality, and identification of dream self with the marital role. The study suggests that some dream characteristics respond adaptively during life changes but that this is delayed when subjects are depressed. This raises the possibility of a corrective intervention for such persons.

Adult↗