Biomedical subjects
Publications and source records attributed to R Cockel.
One hundred and sixty-three patients who had been diagnosed as suffering from diarrhoea without an organic cause were followed up to assess the risk of missing malignant disease. Three patients with carcinoma, two involving the stomach and one the colon had escaped diagnosis and the reasons for this are given. Prognosis in the others was usually good.
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One hundred patients were examined with the Olympus GTF-A fibregastroscope and gastrocamera. The entire stomach was seen in most cases; the technique permitting this is described in detail. The examination was most rewarding in patients with gastric haemorrhage and when radiology was equivocal. Advantages and disadvantages of the instrument are discussed.
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Gastric secretion in man is inhibited by the presence in the duodenum of hyperosmolar and hypoosmolar solutions. Both acid and pepsin outputs are affected. There is no change in hydrogen, sodium, or potassium ion concentration in the gastric juice. Pepsin concentration, however, is reduced by all inhibitory stimuli. Inhibition is thought to act directly upon parietal and chief cells, and a possible basis for this mechanism is discussed. The response is similar in control subjects and duodenal ulcer patients; there is in particular no evidence of impaired inhibition in the ulcer group. An anomalous feature is the relatively small inhibition of acid output after hypertonic saline in control subjects compared with the duodenal ulcer patients.
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