Biomedical subjects

R Chilla

Publications and source records attributed to R Chilla.

129 records · Page 8Linked to original sources

PubMedDate not supplied

The influence of guanoxane on the submaxillary glands of rats. Another model of neurogenic sialoses.

In extracts of submaxillary glands of rats, treated with the guanethidine derivative, guanoxane (Envacar), alpha-amylase activity and protein concentration were measured. Both parameters were also determined for the alpha-isoamylase patterns obtained following electrophoretic separation of gland extracts in polyacrylamide gels. During the first week of drug application, amylase was found to be congested in the glands. Compared with untreated animals, total amylase concentration and amylase activity per unit protein (specific enzyme activity) were significantly increased in extracts and separated isoenzymes, whereas protein concentration remained unaltered. The described changes reverted to normal after continued drug application for 3 weeks. The possibility is suggested that changes in alpha-isoamylase patterns might eventually be employed for clinical characterization of different types of neurogenic sialosis.

Amylases↗

PubMedDate not supplied

Function of submaxillary gland following iatrogenic damage to chorda tympani nerve.

Flow rate, protein and amylase content of submaxillary saliva were determined before and after iatrogenic damage to the chorda tympani nerve during otosurgery. Parallel to these investigations, gustatory function was checked. Chronic otopathy itself did not lead to a disturbance of either the sense of taste or the function of the submaxillary gland in any of the 14 patients. On the other hand, the flow rate of the affected gland dropped after chorda division (8 patients) and after chorda stretching (6 patients), and the protein concentration of the saliva was increased while the concentration of amylase remained unchanged. Dysgeusia was always observed after chorda division but only once among 6 cases of chorda stretching.

Amylases↗

PubMedDate not supplied

Late sequelae of iatrogenic damage to chorda tympani nerve.

Four and a half years following middle ear surgery involving damage to the chorda tympani nerve we conducted a follow-up study in 10 out of 14 patients in whom we had previously investigated gustatory and submandibular gland function, pre- and immediately postoperatively. Following transection of the chorda tympani nerve (5 patients) the secretory volume of the affected gland has risen again but is still lower than that of the healthy gland. The secretory volume of the latter is increased, possibly by compensatory hypertrophy. The still existing dysgeusia, not noticed by the patients, is occasionally slightly improved. After stretching of the chorda tympani nerve (5 patients) the function of the submandibular gland and taste perception on the involved side of the tongue are now nearly fully restored.

Chorda Tympani Nerve↗