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Biomedical subjects

R Cheli

Publications and source records attributed to R Cheli.

At least 73 records · Page 4Linked to original sources
PubMed1982

Comparison between ranitidine, cimetidine, pirenzepine and placebo in the short term treatment of duodenal ulcer.

The therapeutic efficacy of ranitidine, pirenzepine, cimetidine and placebo in the 28 day treatment of duodenal ulcer was evaluated through an open randomized study performed in 120 patients. At the end of treatment, ranitidine, pirenzepine and cimetidine demonstrated a significantly higher efficacy on ulcer healing as well as on symptom relief in comparison with placebo (P less than 0.05). Data regarding cimetidine and ranitidine failed to reveal significant differences: pirenzepine, on the contrary, when compared with both the H2 blockers employed showed a slower effect on symptom disappearance. As far as functional data are concerned, placebo administration did not induce any variation of secretory or gastrinemic behaviour: on the contrary, after the end of ranitidine and cimetidine treatment a significant decrease of BAO and of MAO were found, failing to reveal any serum gastrin variation. After pirenzepine therapy no differences in the acid secretory behaviour were seen, while a significant increase of fasting gastrinemia was observed.

Adolescent↗
PubMed1982

Long term treatment of duodenal ulcer with pirenzepine.

Long term pirenzepine treatment of duodenal ulcer patients was carried out. Full dose pirenzepine therapy (100 mg/day) for 28 days resulted in 34 (77%) out of 44 duodenal ulcer patients with endoscopically healed lesions. Sixteen of them, randomly chosen, were treated with low pirenzepine doses (50 mg/day) for 6 months with evidence of clinical and endoscopic ulcer relapse in 3 cases (18.7%); while in 16 subjects who interrupted the treatment completely, evidence of clinical recurrence in 11 (68.7%) and of endoscopic recurrence in 10 (62.5%) within the following six months. The statistical analysis failed to reveal significant differences between treated and not treated patients. These data were compared with what observed after interruption of treatment in 16 patients whose duodenal ulcer previously healed after 28 days of antacid therapy. Clinical ulcer recurrence in up to 6 months were shown in 9 (56.2%) of them, and endoscopic relapses were shown in 7 (43.7%). In conclusion, the maintenance therapy with low doses of pirenzepine reduces the number of ulcer relapses when compared with pirenzepine withdrawal or with antacid withdrawal, even though this difference is not statistically significant.

Adult↗
PubMed1982

Anatomic-functional behaviour of the gastric mucosa in different clinical phases (acute, quiescent, relapsing) of duodenal ulcer.

The gastric anatomic-functional behaviour (gastric acid secretion, gastrinemia parietal cell mass, histological pattern of the fundic mucosa) was evaluated in 50 duodenal ulcer patients in the active stage of the disease. After 28 days of treatment with cimetidine (1 g/day), the 42 healed patients stopped therapy completely for three months. At the end of the follow-up the anatomic-functional behaviour was monitored and compared with the initial data in the 24 subjects who were still symptomless, as well as in the 18 patients whose duodenal ulcer relapsed. The analysis of the data obtained demonstrated that gastric acid secretion, gastrinemia and morphology of the fundic mucosa do not vary with the different activity phase of duodenal ulcer; therefore additional factors, and in particular alterations of mucosa resistance, are presumed to be responsible for the development of ulcerous lesions. Moreover, a comparison between the initial data of patients with ulcer healing after cimetidine therapy, and of those with unhealed ulcer, failed to reveal any significant differences, thus denying a prognostic value of acid secretion tests in duodenal ulcer disease.

Adult↗
PubMed1981

Chronic gastritis and duodenogastric reflux.

The histological and histochemical patterns of fundic and antral mucosa were assessed in 36 patients with normal pyloric competence and in 28 patients with duodenogastric reflux (DGR), evidenced by Capper's test. There was a significant increase of antral gastritis with normal fundic mucosa in patients with DGR compared with controls. In contrast, patients with DGR show a fundic gastritis incidence similar to that in age-matched controls. The histochemical studies failed to reveal differences between the two groups with and without DGR. These data confirm previous experiences on the possible role of DGR in the pathogenesis of antral gastritis. However, there is no correlation between duodenogastric reflux and fundic gastritis.

Adult↗
PubMed1981

Chronic gastritis and alcohol.

In order to analyse the relationship between the incidence of chronic gastritis and chronic alcohol consumption, the histological pattern of fundic and antral mucosa was studied in 30 asymptomatic non-alcoholic volunteers, 20 heavy drinkers without liver cirrhosis, 39 alcoholics with liver cirrhosis, and 14 non-alcoholic subjects with liver cirrhosis. The data demonstrate an increased incidence of preatrophic gastritis in the fundic as well as in the antral mucosa in abstemious patients with liver cirrhosis, while no significant differences were found between the other three groups. However, the incidence of chronic gastritis, did not show significant differences between the four different groups if subjects of the same age are compared. In conclusion, alcohol does not play an important role in the development of chronic gastritis, particularly in gastritis with major mucosal damage.

Adult↗
PubMed1980

Atrophic gastritis and intestinal metaplasia in asymptomatic Hungarian and Italian populations.

The histological patterns of the gastric mucosa obtained by endoscopic biopsy were evaluated in two different ethnic groups, each containing one hundred patients without gastro-intestinal diseases. The incidence of atrophic gastritis and intestinal metaplasia increased with age in both groups, revealing a statistically significant difference above 60 years. The comparative study of gastric cancer death rates in the two population groups showed a significant prevalence in the Hungarians above 50 years. This fact seems to support the hypothesis that an ethnic group with high gastric cancer rate has a higher prevalence of atrophic gastritis and intestinal metaplasia in the older age groups, and offers additional evidence for the association of chronic inflammatory changes of the gastric mucosa with malignant gastric cancer.

Adult↗
PubMed1979

Parietal cell mass after short and long term cimetidine treatment of duodenal ulcer.

The parietal cell mass (PCM) was evaluated on endoscopically obtained biopsy specimens of fundus mucosa from 20 duodenal ulcer patients before and after cimetidine treatment. Patients were given cimetidine, 1 g/day, for 28 days. Six out of the 18 cases which healed after short-term therapy went on taking 400 mg/day of cimetidine for 9 months. The PCM was expressed by means of an index (PI) obtained by multiplying the mean cell number per mm of section surface by the mean parenchymal thickness. The analysis of the obtained data failed to demonstrate any significant difference between the PI observed before and after 28 days treatment with cimetidine, while after long term treatment for 9 months, a significant increase of the PI was achieved.

Adult↗
PubMed1979

A new type of tube for guided small bowel biopsy.

A new instrument for duodenal and jejunal guided biopsies is described. The instrument is made of a tube, whith a steerable tip, which permits three-dimensional movements, and has a suction capsule. It is constructed by Medi-Tech Cooper Scientific Corporation (USA), and has been used in our department for three months. The technical aspects of this instrument, the procedure and the results achieved are described.

Biopsy, Needle↗
PubMed1979

G cell distribution in normal duodenal mucosa.

G cell presence in the fundus, antrum and duodenum (bulbar, descending and horizontal parts) was investigated by an indirect immunofluorescenc technique in six asymptomatic male subjects. All subjects had normal endoscopic and histological patterns normal gastric acid secretion and normal serum gastrin levels. The results confirm the presence of G cells in the antral mucosa and the three studied duodenal portions. The G cell number of each duodenal portion was significantly lower than the antral one (P less than 0.0005). No difference could be seen between the second and third duodenal portions while each of them had a significantly lower G cell number, when compared with the bulb.

Adult↗
PubMed1978

Morphology of the gastric mucosa, gastric secretion and serum gastrin concentration following a test meal.

In 32 subjects, the HCl secretion, the histological state of the antral and fundic mucosa and the gastrin response to a liquid meal extract were studied. Atrophy of the antrum was associated with normal gastrin concentration in the fasting state and after the test meal, in the presence of normal fundic mucosa and HCl secretion. In achlorhydria and atrophic gastritis, fasting gastrinemia was significantly elevated in subjects with a normal antrum, and only moderately increased in subjects with an atrophic antrum. The gastrin response to feeding was correlated to the fasting gastrin concentration in achlorhydric subjects with normal antral mucosa, in contrast to a uniformly reduced output in achlorhydric subjects with atrophic lesions of the antral mucosa.

Achlorhydria↗
PubMed1978

Treatment of active duodenal ulcer with oral cimetidine: a multicenter controlled endoscopic trial.

A double-blind 4-week trial of cimetidine (1 g daily) versus placebo was conducted in 68 adult outpatients with active duodenal ulceration endoscopically confirmed. 3 of the patient admitted to the study (1 on cimetidine and 2 on placebo) did not complete the trial. After 4 weeks of treatment, 25 of 33 patients (76%) receiving cimetidine had healed their ulcers compared with 15 (47%) of 32 patients receiving placebo (p less than 0.02). Antacid consumption was also significantly decreased by cimetidine when compared with placebo. Tolerability of the drug was good.

Administration, Oral↗