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Biomedical subjects

R Carlisle

Publications and source records attributed to R Carlisle.

At least 37 records · Page 2Linked to original sources
PubMed1984

Reversal of neuromuscular block. Heart rate changes with slow injection of neostigmine and atropine mixtures.

The effect on heart rate of different rates of injection (10 seconds, 1, 3 and 5 minutes) of a fixed dose (neostigmine 2.5 mg and atropine 1.2 mg) and a weight-related dose (neostigmine 50 micrograms/kg and atropine 25 micrograms/kg) of neostigmine-atropine mixture given for the reversal of residual competitive neuromuscular block was studied in 196 healthy adult patients. In both series slow injection lessened and delayed the initial rise in heart rate. The subsequent fall in heart rate was less when the drugs were injected over 3 min compared with the 10 seconds and 1 minute injection groups but when given over 5 minutes there was a steady fall in heart rate, more so with the weight-related dose. It is recommended that a neostigmine and atropine mixture should be administered over 3 min.

Adult↗
PubMed1980

Cardiovascular responses in hypertensive outpatients starting oral propranolol, determined from the brachial pulse upstroke.

Simultaneous measurement of brachial artery pressures, systolic time intervals, initial pulse upstroke gradient and pulse rate was made in 7 adult hypertensive outpatients during rest supine and during bicycle ergometry at 2 different work rates. Measurements were repeated after 1, 6 and 13 wk on oral propranolol 80 mg thrice daily. Rise of pulse upstroke period (reversed after 1 wk) and of inflection time--analogous with preejection period--and fall of inflection, or diastolic, pressure (most marked at 1 wk) can be explained by early reduction of myocardial contractility and pulse rate. The fall of upstroke period, of peak, or systolic, pressure and of pulse rate (more marked after 1 wk) is related to a later 'adaptive' decrease in peripheral resistance. Much useful information can be obtained by such simple examination of the characteristics of the pulse wave in the brachial artery without complex, albeit noninvasive, cardiac investigations.

Administration, Oral↗
PubMed1979

The relationship between conventional liver tests, quantitative function tests, and histopathology in cirrhosis.

Thirty patients with cirrhosis were evaluated with the 2-hr [14C]aminopyrine breath test (score) and with conventional liver tests. Of the 30 patients, 24 also had current liver biopsies. There was a good correlation between necroinflammatory activity in the 24 cirrhotic liver biopsies and the 2-hr aminopyrine scores. All five patients who had at least grade 2 necroinflammatory activity on their biopsy had an abnormal prothrombin time (greater than 3.5 sec above control) and their aminopyrine score was less than 2%. The correlation was good between the 2-hr aminopyrine score and the prothrombin time (seconds over control). No correlation was found between the 2-hr aminopyrine score and either the serum aspartate aminotransferase (SGOT) or any other liver test except for the prothrombin time. It seems that the 2-hr aminopyrine score and prothrombin time are more likely to give a quantitative estimate of total functioning parenchymal mass which is left unaffected by hepatocellular disease in cirrhosis, than the other commonly used liver tests.

Aminopyrine↗
PubMed1977

An approach to realistic evaluation of antihypertensive regimes.

Where practicable, all subjects found with onset-phase-four blood pressure of 90 mmHg or more after referral were allocated, on a random basis, to alternative antihypertensive regimes at a dosage related to response. Of those 110 receiving either guanethidine, methyldopa or debrisoquine, only the group on methyldopa had significantly reduced median blood pressure by two out of four criteria and after 6 months of therapy. It is nevertheless considered that by assessment of the total group more significant conclusions can be drawn for an eventual attempt to control hypertension on a community basis than by studies of highly selected groups treated under unusually favourable conditions.

Adult↗