Biomedical subjects

R C Smith

Publications and source records attributed to R C Smith.

At least 397 records · Page 22Linked to original sources

PubMed1977

Effects of dopamine agonists in tardive dyskinesia.

The authors used a combined behavioral and neuroendocrinological strategy to investigate the relevance of abnormalities in the brain dopaminergic systems to the pathophysiology of tardive dyskinesia by assessing the effects of apomorphine, a directly acting dopamine agonist, and d-amphetamine, an indirectly acting dopamine agonist, in patients with tardive dyskinesia. Administration of I.V. d-amphetamine increased dyskinetic movements in most patients with tardive dyskinesia, a finding consistent with the dopaminergic hypothesis. Contrary to predictions based on animal models, apomorphine did not increase dyskinetic movements in these patients but instead substantially reduced dyskinesia in some patients. Patients with tardive dyskinesia did not have a greater drop in serum prolactin or a greater rise in serum growth hormone after apomorphine than normal or chronic schizophrenic subjects without tardive dyskinesia.

Administration, Oral↗

PubMed1977

Cholinergic influences in tardive dyskinesia.

The authors conducted placebo-controlled double-blind studies of physostigmine, choline, and deanol in 12 patients with tardive dyskinesia. Physostigmine and choline both had a positive therapeutic effect on tardive dyskinesia, but the authors note that interpretation of these results is not entirely clear because they found that the sedation effect of physostigmine may nonspecifically reduce the intensity of tardive dyskinesia symptoms. Deanol was not found to be effective in this group of patients; the authors suggest that this drug should not be assumed to be generally effective unless effectiveness is verified by a large placebo-controlled double-blind study.

Acetylcholine↗

PubMed1977

Electrophysiological (H-reflex) studies of patients with tardive dyskinesia.

The authors studied the H-reflex recovery curves of 31 schizophrenic patients with tardive dyskinesia in response to acute administrations of apomorphine, amphetamine, or physostigmine and compared them with curves of chronic schizophrenic patients without tardive dyskinesia and normal volunteers. Their most unexpected finding was the absence of an H-reflex in 9 of the 31 patients with tardive dyskinesia. They also found a relationship between severity of tardive dyskinesia and the value of the facilitatory peak Hchi: patients with more severe tardive dyskinesia symptoms had significantly higher values for Hchi.

Amphetamine↗

PubMed1977

"Practical suggestions on facila plastic surgery--how I do it". External marking in rhinoplasty planning.

Photographs, drawings, and examination at consultation have value in rhiniplastic planning. However, the surgeon is not operating on photographs, drawings, or an alert sitting or standing patient; he is operating on a nose with what was forward now facing upward. We find it most helpful to plan and mark almost the entire procedure on the external nose and surrounding structures just before the patient is put supine and sedated or anesthetized. In primary rhinoplasty, it is possible to mark essentially all skeletal anatomy within 1 mm tolerances by palpation, pushing the tip up and back, observing the changes from the outside, and looking at the inside. We believe that the anatomy and planned changes can and should be depicted by appropriate marks put on the skin. There mere act of drawing in the procedure forces us to think it through from beginning to end, a most worthwhile endeavor. Moreover, we learned very shortly after we began forcing ourselves to quantitate the anatomy and proposed changes, that we ran into fewer and fewer surprises as we worked. Photographs taken of the markings become by far the best "operative note" we can have. Comparison of these with the patient or his photographs showing the result allow us to make accurate judgments about long term effects of each surgical maneuver. Much that seemed mysterious before is found to be quite scientifically explainable. We do not propose in this short report to show how we mark every nose. Rather we shall show with drawings and a few examples how we go about marking a nose. The reader may use the suggested marking techniques or may evolve his own. The important thing is that he work out a system meaningful to him. It will be noted that we have used differing techniques for depicting similar concepts from case to case. In other words, we have not settled immutably on one system because we are still searching for the best.

Female↗

PubMed1977

Recording projection of nasal landmarks in rhinoplasty.

Because of difficulties in making accurate measurements from before and after photographs, we have devised measuring techniques not dependent upon exact reduplication of photographic circumstances before, during, and after surgery. Measuring devices contacting the head of the patient in specified ways are described. They allow simple and exact reduplication so that measurements made at different times can be compared. Lengths of nose and of columella and actual projection of brow, nasofrontal angle, rhinion, supratip region, the tip itself, and of the columella-labial junction can be measured. Tip rotation, cephalic or caudal, can be determined and quantitated. The devices and techniques for using them are described. We believe that employment of the suggested measuring techniques will allow better reporting of rhinoplastic methods and results should significantly increase our understanding of this complex surgical procedure.

Anthropometry↗

PubMed1977