Search PubMed⌕ Search

Biomedical subjects

R C Goodlin

Publications and source records attributed to R C Goodlin.

At least 163 records · Page 9Linked to original sources
PubMed1983

Relationship between amniotic fluid volume and maternal plasma volume expansion.

Amniotic fluid and maternal plasma volumes were estimated in high-risk obstetric patients suspected of being hypovolemic. Excluding cases of intrinsic maternal or fetal disease, there were good (P less than 0.001) correlations between maternal plasma volume expansion and amniotic fluid volume. In the presence of oligohydramnios, there is usually maternal hypovolemia, and vice versa. Oligohydramnios may often be corrected by vigorous maternal plasma volume expansion, which is sometimes indicated in the treatment of cases of fetal distress. It is presumed that only when maternal plasma volume expansion is normal, is uterine perfusion sufficient to provide amniotic fluid formation in normal amounts. The varying amounts of amniotic fluid seen in normal pregnancies at term probably reflect the varying fetal activities of swallowing and voiding.

Adult↗
PubMed1983

Clinical signs of normal plasma volume expansion during pregnancy.

A majority of cases of pregnancy complications are associated with a relative maternal hypovolemia. The records of 200 pregnant women who had had plasma volume determinations were reviewed in hopes of finding indicators of relative maternal hypovolemia other than the pregnancy complication itself. The signs of relative hypovolemia in pregnant women include those of decreased uterine growth, absence of a maternal systolic flow murmur, and absence of significant dependent ankle edema. Laboratory tests indicative of maternal hypovolemia include failure to develop a decline in maternal hematocrit, serum blood urea nitrogen/creatinine ratio greater than 15, a decreased creatinine clearance, abnormal platelet function, elevated serum glutamic oxaloacetic transaminase, ultrasonic evidence of oligohydramnios and/or decreased maternal heart size, and absence of hypervolemia on chest x-ray film. These findings and tests are only relative indicators of maternal hypovolemia, and it is suggested that, for an accurate defining of pregnant women who are at risk, the actual plasma volume determination has to be performed frequently in the pregnant population.

Aspartate Aminotransferases↗
PubMed1983

Hypovolemic pregnant women and their risk determinants.

Among hypovolemic pregnant women there is a high risk of premature labor, fetal growth retardation, and/or hypertension. Arterial wave velocity was determined and Evan's blue disappearance rates measured in hypovolemic gravidas with complications. It appeared that those hypovolemic gravidas without increased cardiac performance are more likely to give birth prematurely, while those with increased cardiac performance and delayed in vivo mixing of Evan's blue dye develop hypertension.

Electrocardiography↗
PubMed1983

Diagnosis and treatment of pregnancy induced platelet dysfunction.

Pregnant women with either Type B EPH gestosis or gestosis alone were treated with low dose aspirin if thrombocytopenia were present (platelet counts below 75,000) or had platelet aggregation studies if their platelet counts were above 75,000. Platelet aggregation was usually decreased and aspirin therapy appeared to improve platelet counts. However, it appears that platelet abnormalities are only a secondary defect in the "gestosis" process as correction of their thrombocytopenia did not correct their hypovolemia.

Adult↗
PubMed1982

Determinants of maternal temperature during labor.

Intrapartum maternal temperatures and neonatal temperature immediately after birth were measured in 50 cases. Maternal temperatures were determined in part by the amount of hyperventilation, perspiration, and physical activity, with those who were calm and less active having the higher temperatures. Thus, with hyperventilating parturients, it was difficult to define "normal" maternal temperatures. The neonatal rectal temperature immediately after birth seemed best correlated with the maternal vaginal temperature. Two examples are presented which suggest that cases of fetal distress associated with tachycardia and decreased placental exchange may be examples of isolated fetal hyperthermia.

Adult↗
PubMed1982

Why treat "physiologic" anemias of pregnancy?

It is argued that the physiologic anemia of midpregnancy is beneficial in terms of the associated hypervolemia and improved pregnancy outcome. Vigorous treatment of normal pregnant women having physiologic anemias with large doses of medicinal iron is discouraged because higher hematocrits are reported to be less efficient in terms of cardiac work and oxygen delivery, because lower serum iron levels protect against infection and because of the hazards of infant iron poisoning. Pharmacologic doses of iron also obscure the decline in hematocrit seen from the plasma volume expansion in normal pregnancy, removing a simple diagnostic sign of maternal hypovolemia.

Anemia↗