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Biomedical subjects

R C Fowler

Publications and source records attributed to R C Fowler.

At least 55 records · Page 3Linked to original sources
PubMed1980

Alcoholism, depression, and life events.

Alcoholics with and without secondary depression were compared on a wide variety of clinical variables. Subjects with secondary depression reported more fights, arrests, neurotic complaints, suicidal behavior, and recent undesirable life events than subjects with alcoholism alone. The data indicate a close relationship between negative events and the secondary depression of alcoholism. In addition, the findings suggest that the alcoholic with secondary depression is at greater risk for suicide than the alcoholic without a depressive syndrome.

Adult↗
PubMed1979

Symptoms in veterans considering compensation claims.

The symptomatology of 56 male veterans considering compensation claims was compared to the symptomatology seen in 163 veterans not considering such claims. Antisocial behaviors, somatic/neurotic complaints, and persecutory ideas were all positively correlated with consideration of a claim. Although the symptom profile is consistent with diagnosis of antisocial personality, a correlation with this diagnosis was not established. Nonetheless, the clinical profile does suggest a link between noncompensable disorders and consideration of a claim. The implications of this finding for military and Veterans Administration psychiatry are discussed.

Adult↗
PubMed1978

Absorption of oral intramuscular chlordiazepoxide by alcoholics.

The effect of chronic alcoholism on oral and intramuscular plasma levels of chlordiazepoxide (CDX) was assessed. A 50-mg oral dose of CDX resulted in significantly higher plasma levels in the 2 hr following CDX than a 50-mg intramuscular dose administered to acute withdrawing alcoholic subjects. The same CDX dose was administered 7 days later and the same differences were observed between the mean oral and intramuscular plasma levels during the first 2 hr after administration of CDX. Peak concentration occurred significantly sooner after the oral than intramuscular dose of CDX in both the initial dose and the dose given a week later. It was also observed that the areas under the curve for CDX were significantly greater initially than 1 wk later. It is suggested this effect may be at least partially the result of the longer CDX half-lives initially than a week later. The active metabolite, N-desmethylchlordiazepoxide, peaked significantly earlier with the oral dose than with the intramuscular dose after the patient was alcohol free for a week.

Absorption↗
PubMed1978

Remitting schizophrenia as a variant of affective disorder.

Remitting schizophrenia is an important phenomenon in the United States largely because of the broad concept of schizophrenia used here. Clinical and family investigations of this condition suggest a close link between remitting schizophrenia and the affective disorders. However, the elevated morbidity risk of schizophrenia in first-degree relatives of remitting schizophrenics precludes the conclusion that remitting schizophrenia is simply a variant of affective disorders. The following testable hypothesis is consistent with the available data: remitting schizophrenia is a heterogeneous mixture of mania, unipolar depression, and typical schizophrenia. Mania and unipolar depression account for the majority of such disorders although schizophrenia may account for a sizable minority. Other disorders may be included in this mixture; but, their contribution to the remitting schizophrenias is probably small.

Affective Disorders, Psychotic↗
PubMed1977

Water intoxication, psychosis, and inappropriate secretion of antidiuretic hormone.

A review of the literature and the three presented cases indicate that multiple factors are often involved in the development of water intoxication in the psychotic. Although the syndrome of inappropriate secretion of antidiuretic hormones (SIADH) is one of these factors, it is usually associated with other causes of the SIADH. Evidence is lacking that the SIADH is an essential feature of a psychotic illness.

Delusions↗
PubMed1975

Non-psychotic disorders in the families of process schizophrenics.

The present study was designed to test the hypothesis of "schizophrenic spectrum" disorders. The families of 60 process schizophrenics were systematically interviewed with structured interview forms, and evaluated for psychiatric illness according to strict diagnostic criteria. The interviewed persons were then separated into two groups for comparative analysis according to a positive (FH+) or negative (FH-) family history for schizophrenia. The frequencies of affective disorder and all non-psychotic conditions did not differ to a convincingly significant degree between the two groups. Our data thus fail to support the "schizophrenic spectrum" hypothesis in which neurosis and sociopathy occur as a consequence of a genetic loading for schizophrenia.?

Adult↗