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Biomedical subjects

R C Eagle

Publications and source records attributed to R C Eagle.

At least 253 records · Page 14Linked to original sources
PubMed1975

Cholesterolosis of the anterior chamber.

The clinicopathologic findings in eight eyes with cholesterolosis of the anterior chamber are presented. In five patients the cholesterol was present as an anterior chamber deposit or free-floating crystals, or both, and was recognized clinically. In two patients the anterior chamber cholesterol had incited a granulomatous inflammatory reaction and was mistaken clinically for lipid keratopathy. Anterior chamber crystals were an incidental laboratory finding in the final patient. Intraocular cholesterol may be present as free crystals or contained within foreign body granulomatous inflammation, macrophages, or fibrous tissue. Possible sources of anterior chamber cholesterol crystals are discussed. In most cases they seem to be derived from the breakdown of intraocular hemorrhage.

Adolescent↗
PubMed1975

Pigmentation and retinal breaks.

Of 260 patients with primary, nontraumatic, rhegmatogenous retinal separation analyzed for the presence of retinal or subretinal pigmentation associated with the retinal breaks, some 48.5% of all patients had significant pigmentary changes, especially occurring with lattice degeneration and nonlattice horseshoe tears. Critical analysis of the age of the patient, type of retinal break, vitreoretinal degeneration, and type and extent of pigmentation is essential before ascribing a protective effect of the pigment in the prevention of subsequent retinal separation.

Humans↗
PubMedDate not supplied

Plasmacytoma of the eye and orbit.

BACKGROUND: Plasmacytomas of the ocular and adnexal tissue are rare. The variation in their clinical manifestations and potential association with multiple myeloma are not well appreciated. METHODS: We reviewed the clinical features and laboratory data of five cases of plasmacytoma involving the eye and orbit. RESULTS: Plasmacytomas involved the conjunctiva in one case, the orbit in three cases, and the iris in one case. Plasmacytoma was the solitary plasma cell neoplasm in a patient with a conjunctival lesion and another patient with an orbital lesion. Two other patients who developed plasmacytomas of the orbit and iris, respectively, had a known history of multiple myeloma. An orbital plasmacytoma preceded the onset of systemic plasma cell neoplasia in the final patient. CONCLUSION: Plasmacytomas of the eye and orbit are rare. They may or may not be associated with multiple myeloma.

Aged↗
PubMedDate not supplied

Infantile endogenous Candida endophthalmitis presenting as a cataract.

The most common pathogen to cause endogenous endophthalmitis is the fungus Candida albicans. Most cases involve adults who are either immunosuppressed or have a history of repeated or prolonged extracorporeal access to their circulatory system. Endogenous Candida endophthalmitis can occur in infants as well, particularly when prematurity, broad spectrum antibiotic therapy, or prior surgery are present as predisposing factors. We report the clinical and histopathological findings of an infant who developed a unilateral, sectoral lens opacity four months after undergoing treatment for disseminated candidiasis. The diagnosis of localized intralenticular fungal abscess with associated endophthalmitis was made via histopathologic examination of the aspirated lens material. Treatment with systemic antifungal agents successfully preserved the eye. In addition, we review and summarize the previously reported cases of Candida endophthalmitis in patients under one year of age.

Amphotericin B↗
PubMedDate not supplied

Iris melanoma in a patient with neurofibromatosis.

Neurofibromatosis type 1 (NF1) is a common autosomal dominant hamartomatous disorder, which is considered to be a neurocristopathy. Uveal melanoma, also of neural crest origin, is the most common primary malignant intraocular tumor in adults. The association of NF1 and uveal melanoma is controversial. We present a clinicopathologic report of iris melanoma in a patient with NF1 and review the literature for a possible causal association. To our knowledge, only 18 cases of uveal melanoma, including three cases of iris melanoma, have been reported in association with NF1. On the basis of the prevalence of NF1 (1 in 3000) and the prevalence of uveal melanoma (1 in 13,500), it can be estimated that approximately seven patients with NF1 in the United States would have an associated uveal melanoma by chance alone. We conclude that despite the theoretical possibility of a causal association of uveal melanoma and NF1, it may still be regarded as coincidental in the absence of any strong evidence to the contrary.

Adult↗
PubMedDate not supplied

Lung cancer with visual loss.

A 58-year-old man with primary large cell carcinoma of the lung presented with rapidly progressive, bilateral visual loss. The patient was alert and oriented, had no complaints of headache, and was found to have full ocular motility. The optic disks and fundi appeared normal. No visual pathway lesions or other CNS abnormalities were detected on neuro-imaging. The authors discuss their differential diagnosis, clinical diagnostic approach, and subsequent management of this unusual patient.

Carcinoma, Large Cell↗
PubMedDate not supplied

Transscleral choroidal biopsy in the diagnosis of choroidal lymphoma.

A 57-year-old man with non-Hodgkin's B-cell lymphoma of the abdominal lymph nodes developed moderate cells in the anterior chamber and vitreous, choroidal infiltration, and total nonrhegmatogenous retinal detachment in both eyes while receiving chemotherapy. After a diagnostic vitrectomy in the left eye was nonrevealing, the patient was referred to the oncology service. Fine-needle aspiration biopsy of the choroidal infiltrate was not done because of poor visualization of the choroid through the turbid subretinal fluid. Transscleral choroidal biopsy was performed without complications and disclosed diffuse high-grade B-cell lymphoma and no signs of endogenous infection. Transscleral choroidal biopsy is a useful technique in eyes with choroidal infiltration, especially when hazy media prohibit fine needle biopsy.

Biopsy, Needle↗
PubMedDate not supplied

MR imaging of a carcinoid tumor metastatic to the orbit.

This is a report of the magnetic resonance study in a case of orbital metastasis from a carcinoid tumor. A rather unusual feature of this lesion was its relatively short T2 as compared with other metastatic orbital lesions.

Aged↗
PubMedDate not supplied

Iris melanoma in a ten-year-old boy with familial atypical mole-melanoma (FAM-M) syndrome.

A ten-year-old boy was referred with an enlarging amelanotic iris tumor and secondary glaucoma in the left eye. After excisional biopsy it proved histopathologically to be an iris melanoma. The patient also had multiple nevi on his trunk, scalp, and buttocks suggestive of familial atypical mole melanoma (FAM-M) syndrome and confirmed histopathologically. To the authors' knowledge, this is the first report of iris melanoma in association with FAM-M syndrome. The young age at tumor onset is suggestive of a predisposing condition such as FAM-M syndrome. The association of uveal melanoma with FAM-M syndrome is discussed.

Child↗
PubMedDate not supplied

Unusual presentation of advanced Coats' disease.

The authors report the case of a 19-month-old boy with advanced Coats' disease whose presenting manifestation was turbid, lipoproteinaceous fluid filling the anterior chamber. The possible sites of origin and routes of migration of the turbid fluid into the anterior chamber are discussed.

Anterior Chamber↗