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Biomedical subjects

R C Eagle

Publications and source records attributed to R C Eagle.

At least 235 records · Page 13Linked to original sources
PubMed1983

The myofibroblastic component of rubeosis iridis.

Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. Fresh and deparaffinized tissue from patients with diabetes mellitus, central retinal vein occlusion, and retinoblastoma were studied. Scanning electron microscopy revealed extensive peripheral anterior synechia formation and flattening and effacement of the anterior iridic surface by a confluent fibrovascular membrane. New vessels on the anterior iris uniformly were hidden beneath a clinically inapparent, superficial layer of myofibroblasts, ie, fibroblastic cells with smooth muscle differentiation. Myofibroblasts may provide the motive force for synechial closure and ectropion iridis in neovascular glaucoma.

Fibroblasts↗
PubMed1983

Choroidal melanoma with retinal perforation and vitreous hemorrhage: a scanning electron microscopic study.

Extensive retinal perforation and subsequent growth within the vitreous cavity permitted the scanning electron microscopic examination of a primary, mixed cell type malignant melanoma of the choroid. The surface of the tumor was covered by fusiform cells oriented in a longitudinal, parallel fashion. Plumper globoid, presumed epitheloid forms were interspersed among the spindle cells. In some areas, the spindle cells had long tapering processes. At the margin of the tumor, slender fascicles of parallelly oriented, proliferating spindle cells were identified. This fascicular growth pattern has been observed in previous tissue culture and scanning electron microscopic studies. Vitreous hemorrhage which occurred in our case may herald a malignant melanoma that has perforated the retina. Additionally, retinal perforation may signify an aggressively growing tumor which should be treated.

Aged↗
PubMed1982

Ocular findings in human babesiosis (Nantucket fever).

Human babesiosis (Nantucket fever) is a rare, tick-borne intraerythrocytic parasitic disease characterized by fever, lymphadenopathy, arthralgias, and hemolytic anemia. A 34-year-old woman, who had previously undergone surgical removal of her spleen, was hospitalized because of presumed hepatitis. The many retinal nerve fiber layer infarcts and serologic abnormalities suggested collagen disease. The diagnosis of babesiosis was established by the demonstration of intraerythrocytic parasites and a greatly elevated titer to Babesia microti. The infection was treated with chloroquine, orally administered quinine, and pyramethamine, and her symptoms resolved within one month. The retinopathy was probably the result of focal vasculitis secondary to immune complex disease caused by chronic infection.

Adult↗
PubMed1982

The atypical pigmentary retinopathy of Kearns-Sayre syndrome. A light and electron microscopic study.

Two postmortem eyes from a 52-year-old man with Kearns-Sayre syndrome were examined by light, scanning, and transmission electron microscopy. Prior to death, pronounced ptosis, total external ophthalmoplegia, an episodic ventricular cardiac arrhythmia, and an atypical pigmentary retinopathy characterized by "choroidal sclerosis" and pigment clumping were documented. Histopathologic examination revealed atrophy of the retinal pigment epithelium and outer retina that was most marked posteriorly. The preservation of photoreceptors appeared to mirror the health of the underlying retinal pigment epithelium. Numerous healthy appearing rods were present in the relatively well-preserved temporal retina. The pattern of photoreceptor degeneration observed in this form of "atypical retinitis pigmentosa" suggests that the primary defect may reside in the retinal pigment epithelium.

Adolescent↗
PubMed1982

Pseudoretinitis pigmentosa secondary to preretinal malignant melanoma cells.

A 75-year-old white woman with a previously diagnosed malignant melanoma of the choroid presented with pseudoretinitis pigmentosa secondary to epiretinal pigmented cells. Histopathologic examination of the enucleated globe revealed that the retinal pigmentation was due to a preretinal membrane of spindle A malignant melanoma cells, which had been dispersed by the tumor. Scanning electron microscopy of the preretinal tumor cells revealed characteristics similar to those previously reported in tissue culture. The pigment dispersion was associated with retinal perforation by the melanoma, denoting an aggressive, growing tumor that should be treated rather than observed.

Aged↗
PubMed1980

Retinal pigment epithelial abnormalities in fundus flavimaculatus: a light and electron microscopic study.

Light, fluorescent, and scanning and transmission electron microscopic examinations of two postmortem eyes from a 24-year-old man with well-documented fundus flavimaculatus with atrophic macular degeneration revealed striking abnormalities in the retinal pigment epithelium (RPE). Beginning near the equator, scanning electron microscopy demonstrated a progressively marked heterogeneity in the size of the RPE cells. Surrounded by a fairly regular mosaic of relatively normal appearing cells, enormously enlarged hypomelanotic cells measuring up to 80 microns in diameter occurred in irregular aggregates that became more prevalent posteriorly. Diffusely and intensely PAS-positive, the RPE was packed with a granular substance with ultrastructural, autofluorescent, and histochemical properties consistent with an abnormal form of lipofuscin. The greatest concentration of lipopigment was noted posteriorly. Stains for acid mucopolysaccharide were only mildly positive. The clinical and fluorescein angiographic manifestations of fundus flavimaculatus are consistent with accumulation of a lipofuscin-like substance in the RPE. The massive amounts of lipopigment encountered in this young individual suggest that disordered lipopigment metabolism may play a major role in the pathogenesis of this retinal pigment epithelial disorder.

Adult↗
PubMed1980

Conjunctival biopsy as an aid in the evaluation of the patient with suspected sarcoidosis.

Conjunctival biopsy is an underused but simple technique in the evaluation of the patient with sarcoidosis and occasionally other systemic diseases. In 55% of patients with biopsy-proven sarcoidosis from other sites, a blind conjunctival biopsy was positive. Bilateral conjunctival biopsies and the examination of multiple sections of each biopsy were essential to obtain this high of a yield. There was no relationship between an anterior uveitis and a positive conjunctival biopsy.

Biopsy↗
PubMed1980

The iris naevus (Cogan-Reese) syndrome: light and electron microscopic observations.

The light and electron micrscopic findings in an eye enucleated from a 38-year-old woman with iris naevus (Cogan-Reese) syndrome are presented. The clinical manifestations of this disease, namely, iridic stromal matting, iridic nodule formation, and unilateral angle-closure glaucoma, appear to be secondary to an endothelial membrane on the anterior surface of the iris. The iris naevus syndrome is now thought to represent one end of the clinical spectrum of an iridocorneal endothelial syndrome which also includes those clinical entities classified previously as Chandler's syndrome and essential iris atrophy.

Adult↗
PubMed1979

The basement membrane exfoliation syndrome.

Previous observations suggest that "pseudoexfoliation of the lens capsule" may be a disease in which cells produce abnormal basement membrane material. Electron microscopic studies indicate that exfoliative material can be produced by cells throughout the anterior segment of the eye. This report describes abundant exfoliative material on the ciliary and iridic epithelia but not on the surface of the lens whose epithelial cells were completely necrotic. Exfoliative material also was observed in the anterior iridic stroma close to a newly formed abnormal endothelial basement membrane, suggesting that exfoliative material may be produced locally within the iris. Furthermore, typical exfoliative material, best considered a filamentous, banded basement membrane with 500-A periodicity, in the wall of a short posterior ciliary artery in the orbit indicates that the exfoliative process is not solely limited to ocular tissues. The term "basement membrane exfoliation syndrome" is proposed for this entity.

Aged↗
PubMed1979

Proliferative endotheliopathy with iris abnormalities. The iridocorneal endothelial syndrome.

Sixteen cases of essential iris atrophy and two of iris nevus (Cogan-Reese) syndrome were reviewed retrospectively by light and electron microscopy. Varying degrees of corneal endothelial proliferation onto the trabecular meshwork and anterior iris were seen in all cases. The demonstration of an endothelial-abnormal basement membrane complex on the anterior iridic surface, deep to synechias in over half the cases, indicates that endothelialization may be primary, since it precedes the formation of anterior synechias. Pathologic and clinical evidence suggests that the iris nevus syndrome, Chandler's syndrome, and essential iris atrophy represent a continuum of clinical manifestations of a single disease process involving proliferation of the corneal endothelial and characteristic iris abnormalities; the latter may be secondary to variations in the pattern, rate, and extent of endothelial proliferation. We suggest the term "proliferative endotheliopathy" to emphasize the common pathogenetic role of corneal endothelial proliferation in all three entities (iris nevus syndrome, Chandler's syndrome, and essential iris atrophy). A more succinct alternate term is "the iridocorneal endothelial (ICE) syndrome."

Adult↗
PubMed1978

Malignant medulloepithelioma of the optic nerve in a horse.

An 18-month-old Standardbred filly had a large intraocular tumor involving the optic nerve. The tumor was a malignant medulloepithelioma, a rare intraocular neoplasm derived from the primitive medullary epithelium. By light microscopy the tumor had cords and lobules of primitive neuroepithelial cells that formed clefts and true rosettes. Electron microscopy of the rosettes showed a girdle of zonulae adherentes joining the apices of the cells as well as several basal bodies. This is the sixth report of equine intraocular medulloepithelioma, and, to the best of our knowledge, the first intraocular medulloepithelioma arising from the optic nerve head in a horse. Massive involvement of the optic nerve should be suspected when an eye containing an intraocular mass in the posterior segment lacks light perception. In such cases a long segment of opitc nerve should be resected.

Animals↗
PubMed1977

Intraocular wooden foreign body clinically resembling a pearl cyst.

Five years after injuring his right eye with a wooden arrow, an 11-year-old boy had an iris lesion resembling a pearl cyst. Surgery demonstrated an intraocular wooden foreign body. Wooden foreign bodies are uncommon but may be surprisingly well tolerated if uncontaminated. A differential diagnosis of iris mass lesions in the posttraumatic eye is provided.

Anterior Chamber↗
PubMed1977

Retinoblastoma simulating Coats' disease: a clinicopathologic report.

A case report of a male infant with leukocoria and a clinical picture of Coats' disease is presented. The correct diagnosis was suggested by contact B-scan ultrasonography, which demonstrated an exophytic mass with calcification compatible with retinoblastoma. The value of this technique in the differential diagnosis of retinoblastoma is discussed.

Child, Preschool↗
PubMed1976

Specific retinal breaks in aphakic retinal separation.

The frequency and location of specific retinal breaks in a consecutive series of 169 phakic and 121 aphakic primary nontraumatic rhegmatogenous retinal separations categorized into lattice and nonlattice groups was determined. Small horseshoe tears in the oral region of the retina at the posterior vitreous base were responsible for 44.1% of aphakic nonlattice detechments. Aphakic detachments associated with lattice degeneration had a greater relative frequency of associated nonlattice tractional breaks in addition to lattice breaks.

Aged↗