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Biomedical subjects

R C Benson

Publications and source records attributed to R C Benson.

At least 109 records · Page 6Linked to original sources
PubMed1978

Primary yolk-sac (endodermal sinus) tumor of the prostate.

A primary yolk-sac (endodermal sinus) tumor of the prostate occurring in a 51-year-old man is described, and the difficulties associated with classification of this tumor are discussed. Yolk-sac tumors have been reported to arise in several extragonadal sites, but to our knowledge this is the first documented case of a germinal cell tumor occurring the the prostate. This tumor in extragonadal sites carries a grave prognosis. Despite radical surgery, radiotherapy, and chemotherapy, this patient died 10 months after the tumor was diagnosed.

Dysgerminoma↗
PubMed1978

Chemical hypophysectomy for relief of bone pain in carcinoma of the prostate.

A series is presented of 10 patients with intractable pain secondary to diffuse metastatic prostatic carcinoma. These patients underwent pituitary ablation by a new method of chemical hypophysectomy, which consisted of multiple injections of absolute alcohol into the pituitary gland under stereotaxic control. Of the 10 patients 9 had good to excellent pain relief. There was no operative mortality. The sequelae are those associated with pituitary destruction, the most significant being diabetes insipidus. Preoperative and postoperative hormonal studies failed to reveal any significant hormonal changes despite good and almost immediate pain relief.

Diabetes Insipidus↗
PubMed1977

Cyclophosphamide hemorrhagic cystitis requiring urinary diversion.

Hemorrhagic cystitis secondary to cyclophosphamide is a well recognized and unique urologic complication of this widely used agent. Cessation of the drug and supportive care are usually sufficient for management but refractory cases are difficult to treat and potentially life-threatening. A review of the pathology and treatment of this disorder is presented with specific reference to a patient requiring urinary diversion.

Adult↗
PubMed1977

Complications of single and multistage operations for hypospadias: a comparative review.

From 1970 through 1975, 198 children with hypospadias were operated upon at our clinic. Three basic types of primary urethroplasty were used: 1) a modified 2-stage Cecil urethroplasty after separate straightening, 2) a modified 1-stage Denis Browne procedure after prior correction of chordee and 3) a 1-stage combined repair of hypospadias and chordee. A comparative review of early complications is presented.

Humans↗
PubMed1977

Mutagenicity for Salmonella typhimurium of urine obtained from humans receiving nitrofurantoin.

Urine samples from 12 humans receiving oral therapeutic doses of nitrofurantoin were mutagenic for Salmonella typhimurium strain TA 100 and nonmutagenic for strain TA 100-FR1. Mutagenic activity of the urine was not increased by treatment with beta-glucuronidase. Spot mutation assay of the chromatogram of urine revealed that the mutagenic activity of the urine was mainly due to unmetabolized nitrofurantoin.

Humans↗
PubMed1977

The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974.

A population-based study of mumps orchitis over a 40-year period in Rochester, Minnesota, is reported. All medical records for patients with orchitis, atrophic testis, parotitis, and diagnosed or suspected mumps for the population of Rochester were reviewed, and detailed abstracts were prepared for all those with mumps orchitis. Information abstracted included the relationship of testicular to parotid involvement, the presence of unilateral or bilateral testicular involvement and subsequent atrophy, the presence of other complications of mumps, the treatment of mumps orchitis, and the presence of other major diagnoses. Also investigated was the number of subsequent congenital malformations in male offspring of these patients. The age distribution of the patients with orchitis (median age, 29 years) differed appreciably from those with mumps (median age, 8 years). There was no apparent increase in genitourinary malformations in the male offspring conceived after the occurrence of mumps orchitis in the fathers. Of the 132 men who had orchitis, 2 subsequently had testicular neoplasms. Both of these patients were in the group of 47 who were noted to have an atrophic testis after the occurrence of orchitis.

Adolescent↗
PubMed1977

Incidence of malignant testicular tumors in the population of Rochester, Minnesota, 1935 through 1974.

Twenty-four cases of testicular neoplasms detected in male Rochester residents over a 40-year period were identified using the Rochester-Olmsted County epidemiologic data base. This resource contains nearly complete medical information on residents of Rochester, Minnesota, and the surrounding community. An incidence rate of 3.7/100,000 males per year was calculated. This agrees well with other rates reported in the literature which range from 2.5 to 3.7/100,000 per year; there was no detectable trend over time.

Adolescent↗
PubMed1976

Postpartum onset of urinary incontinence associated with ureteral ectopia.

The onset of urinary incontinence in adult women in association with extrasphincteric ureteral ectopia is rare. Herein we report 2 cases of this unusual occurrence. The incontinence in both patients began after significant obstetric trauma. Ureteral ectopia should be included in the differential diagnosis of incontinence beginning in the immediate postpartum period.

Adult↗
PubMed1976

Complications of single and multistage operations for hypospadias: a comparative review.

From 1970 through 1975, 198 children with hypospadias were operated upon at our clinic. Three basic types of primary urethroplasty were used: 1) a modified 2-stage Cecil urethroplasty after separate straightening, 2) a modified 1-stage Denis Browne procedure after prior correction of chordee and 3) a 1-stage combined repair of hypospadias and chordee. A comparative review of early complications is presented.

Child↗
PubMed1974

Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism.

The immunoreactive forms of parathyroid hormone (iPTH) in the plasma of six patients with primary, adenomatous hyperparathyroidism and six patients with ectopic hyperparathyroidism due to non-parathyroid cancer were compared by using gel filtration on columns of Bio-Gel P-150 and radioimmunoassay of iPTH in eluted fractions after concentration. We found much less (p<0.001) small (mol wt<9,500) COOH-terminal fragments of iPTH in plasma samples from ectopic hyperparathyroid patients (0.52+/-0.13 ng eq/ml) than in samples from primary hyperparathyroid patients (3.70+/-1.15 ng eq/ml). The quantity of iPTH eluting with or before native bovine PTH [1-84] was the same in both syndromes (ectopic hyperparathyroidism, 0.82+/-0.22 ng eq/ml; primary hyperparathyroidism, 0.73+/-0.09 ng eq/ml), and these values correlated positively with plasma calcium concentration (ectopic hyperparathyroidism, r=0.908; primary hyperparathyroidism, r=0.919). In both syndromes, plasma samples had an iPTH component that eluted well before PTH [1-84] (mol wt 9,500), but this component was present in much larger quantities in three patients with ectopic hyperparathyroidism. We conclude that (a) the decreased quantity of biologically inactive COOH-terminal fragments of iPTH circulating in ectopic hyperparathyroidism accounts for the previously reported relatively lower total serum iPTH values in this syndrome as compared with primary hyperparathyroidism (Riggs et al. 1971. J. Clin. Invest. 50: 2079); (b) there appears to be sufficient iPTH with presumed biologic activity to account for the hypercalcemia in both syndromes; (c) a large PTH component, not previously recognized in plasma, is present in both ectopic and primary hyperparathyroidism and may exist as the predominant immunoreactive form of the hormone in some patients with ectopic hyperparathyroidism.

Adenocarcinoma↗