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Biomedical subjects

R Bergman

Publications and source records attributed to R Bergman.

At least 253 records · Page 14Linked to original sources

Understanding the patient in all his human needs.

The 'patient' whether an individual, family or group has multiple human needs. These needs vary with the characteristics of the patient, the state of health/illness and the setting in which care is delivered. Needs may be of a psychological, physical and/or social nature, with dynamic interaction between and within these areas. The patient is part of a large system, the family and society, and here also mutual impact takes place. Time and space take on new meaning in periods of stress and the nurse must be sensitive to the humans needs which grow out of these changed perceptions. Factors which may contribute to meeting patient needs are a systematic method of learning about the patient, basing care on his specific needs, knowledgeable and skilled care givers and an appropriate environment.

Adult↗

Production of a feline parvovirusvaccine using monolayer cell systems in roller flasks and microcarriers.

A parvovirus-strain originating from a case of spontaneous panleukopenia has been adapted and propagated in a feline lung fibroblastic cell line. Cultivation of parvovirus infected monolayer cells was carried out in 11 glass flasks containing 50 ml media and on microcarriers in 0.5 - 101 stirring flasks with 0.5-61 media. Harvest of propagated virus from flask monolayer and microcarrier cultures was performed daily for 5 days during one week. The yields of virus antigen per/ml tissue culture media were equal in the two systems, as monitored by hemagglutination and ELISA assays. The seeding and harvesting procedures of virus were found to be simpler with the microcarrier system than with roller flasks. The scaling up is in progress and comparable results have been obtained in 101 scale.

Animals↗

Mutagens in larger fungi. I. Forty-eight species screened for mutagenic activity in the Salmonella/microsome assay.

Specimens of large fungi (mushrooms) were screened for mutagenic activity by the Salmonella/microsome assay, with strains TA98, TA2637 and TA100. Our of 48 species tested, 37 exhibited a significant but for the most part weak activity. The activity observed in the presence of S9 mix was typically between 0 and 50% of that without, and in no case was the activity increased in the presence of microsomal enzymes. Six metabolites reported to occur in some of the species included in this investigation were also tested. Significant mutagenic activity was found with isovelleral (5) from Lactarius sp., agaritine (3) from Agaricus bisporus and related sp. and beta-nitraminoalanine (7) from Agaricus silvaticus. Isovelleral may be a major mutagen in some of the sharp-tasting and mutagenic Russulaceae sp. A. bisporus (cultivated specimen) was weakly mutagenic toward all three strains of S. typhimurium, used, and agaritine was weakly active toward TA2637 alone. This implies that this fungus might contain other mutagenic material as well. beta-Nitraminoalanine was not found in the particular collection of A. silvaticus tested here. The mutagenicity observed for the fungus in this work may therefore be due to other metabolites. Even though many species found to be mutagenic are used as food, it seems premature to make specific recommendations about eventual health risks. Further information is needed about the chemistry and toxicology of the active compounds as well as about the effects of various methods used in preparing mushrooms for food.

Animals↗

Evaluation of care for the aged: a multipurpose guide.

There is a growing recognition of the need to evaluate quality of care. As the aged are a particularly vulnerable group, often dependent on care-givers for their remaining years, it is important to control related services. An interdisciplinary workgroup prepared a tool which lists cues to be considered in determining the quality of care for the age in ambulatory services, home care programmes, short-and long-term institutions. The cues fall into six domains: physical environment, psychosocial environment, basic personal care, health care, family involvement and manpower. The tool can be used by clients and families for selecting placement for care; by caregivers in choosing or remaining in a place of work; by those administratively responsible for care, such as supervisors, or licensing bodies for controlling performance and policy; and by other involved persons, such as educators, researchers, volunteers or funding agencies for their specific purposes.

Aged↗

Working women and breastfeeding in Israel.

Two-hundred and ninety-one working women in Israel were interviewed 7-9 months after childbirth. The mean number of months that they had breastfed was 2.03. The duration of breastfeeding increased with religiousity and higher education. Women born in Europe, primiparas and grandparas (4 + children) and those over the age of 40 breastfed longer. Most of the women returned to work only after completing breastfeeding. Duration of breastfeeding was reduced when the mother suffered from stress, tiredness, encountered feeding problems, or if the baby cried excessively.

Adult↗

In vitro assays of cell-mediated immunity in calves with persistent Mycobacterium avium infections do not correlate with delayed skin hypersensitivity.

A long-term kinetic study of the immune response of four calves experimentally infected with a M. avium strain was made using the following tests: lymphocyte stimulation (LS), leukocyte migrationinhibition (LMI), delayed skin hypersensitivity (DHS), and a radioimmunoassay (RIA) procedure for antibodies to M. avium. The cell-mediated immune (CMI) responses measured by these tests showed different courses during the infection period. The LS test showed several periods of peak values and the LMI test two peaks of responses of relatively shorter duration. At the end of the experimental period the DHS responses had decreased to insignificant levels, whereas the lymphocytes from all the calves responded in the LS test. No correlation could be detected between CMI and antibody mediated responses, and only two of the infected calves showed clear cut antibody responses measured by RIA. The results probably reflect the measurement of different aspects of the CMI response in the different test systems. The cyclical nature of the CMI measured by the LS and LMI tests may indicate the influence of regulatory mechanisms by suppressing lymphocyte sub-populations.

Animals↗