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Biomedical subjects

R Berg

Publications and source records attributed to R Berg.

At least 127 records · Page 7Linked to original sources
PubMed1987

The gut as a portal of entry for bacteremia. Role of protein malnutrition.

The current studies were performed to determine the influence of malnutrition alone or in combination with endotoxemia in promoting bacterial translocation from the gastrointestinal tract. Bacterial translocation did not occur in control, starved (up to 72 hours), or protein-malnourished (up to 21 days) mice not receiving endotoxin. Bacterial translocation to the mesenteric lymph nodes (MLNs) occurred in 80% of control mice 24 hours after receiving endotoxin (p less than 0.01). However, the combination of malnutrition plus endotoxin was associated with a higher incidence of translocation to the systemic organs (p less than 0.01), and higher numbers of bacteria per organ (p less than 0.01), than was seen in normally nourished mice receiving endotoxin. Additionally, mice that were protein malnourished were more susceptible to the lethal effects of endotoxin than were control animals, and the mortality rate was directly related to the degree of malnutrition (R2 = 0.93) (p less than 0.05). Histologically, endotoxin in combination with protein malnutrition resulted in mechanical damage to the gut mucosal barrier to bacteria. Thus, in the mice that were protein malnourished the spread of bacteria from the gut could not be controlled nor could translocated bacteria be cleared as well as normally nourished mice receiving endotoxin. These results support the concept that under certain circumstances the gut may serve as a clinically important portal of entry for bacteria.

Animals↗
PubMed1986

Thermal injury promotes bacterial translocation from the gastrointestinal tract in mice with impaired T-cell-mediated immunity.

We have shown previously that after thermal trauma viable bacteria will cross the intact gastrointestinal mucosa (bacterial translocation) to invade the mesenteric lymph nodes and other organs if the normal indigenous microflora is disrupted, allowing bacterial overgrowth. To determine whether T-cell-mediated immunity (T-CMI) was important in preventing translocation after thermal injury in animals with an intact normal flora, conventional (+/+), athymic (nu/nu), and heterozygous (nu/+) mice receiving a 30% third-degree burn were killed at various intervals after burn and their organs cultured. Bacterial translocation did not occur in control or burned specific pathogen-free mice with intact T-CMI but did occur in athymic mice with deficient T-CMI. Both the incidence of positive organs and the numbers of translocated bacteria per gram of organ were increased after thermal injury. Bacterial overgrowth was not responsible for these findings, since the levels of cecal enteric bacteria were not different between the burned and nonburned groups. Since translocation occurred to a greater extent in athymic burned mice than control athymic mice, it appears that a thermal injury promotes translocation by impairing other host defense systems in addition to the T-CMI.

Animals↗
PubMed1986

Anatomical studies into the ruminal mucosa of pygmy goats in relation to their age.

The ruminal mucosa of 15 pygmy goats of different age (Z1 approximately 4-5 months, Z2 approximately 1 year, Z3 approximately 1.5-5 years) were studied gross-anatomically concerning their colour, clumping of papillae, fodder precipitations on the papillae, areas poor in papillae or devoid of them and the development of papillae. The density of papillae/cm2 in the 3 groups investigated was 79.4; 67.3; 58.0; the mean length of the papillae (mm) 1.75; 1.86; 2.96; the mean breadth of the papillae (mm) 1.3; 1.2; 2.0; the area of the ruminal mucosa (cm2) 799; 943; 1 195; the area of the ruminal pillars (cm2) 38; 41; 69; the number of the papillae/rumen 59,940; 58,022; 64,782; the total absorptive area (cm2) 3,802; 3,854; 11,268; the surface magnifying factor 4.0; 3.4; 8.4.

Aging↗
PubMed1986

Histological studies into the ruminal mucosa of pygmy goats in relation to their age.

Ruminal mucosae of 15 pygmy goats of different age (Z1 approximately 4-5 months, Z2 approximately 1 year, Z3 approximately 1.5-5 years) and sex were investigated histologically. The thickness of the Stratum corneum of the 3 experimental groups was in the Atrium ruminis 23.0, 23.0 and 29.1 microns, in the Recessus ruminis ventralis 22.8, 28.0 and 30.0 microns, that of the Stratum germinativum and Stratum granulosum in the Atrium ruminis 74.8, 78.4 and 82.3 microns and in the Recessus ruminis ventralis 87.4, 84.7 and 87.7 microns, that of the Corpus papillare in the Atrium ruminis 75.3, 75.2 and 74.4 and in the Recessus ruminis ventralis 85.0, 78.9 and 71.6 microns. The cell nuclear volumes of the basal and parabasal cells of papillae originating from the Atrium ruminis (a) and the Recessus ruminis ventralis (b) in the individual experimental groups were in case of a 103.2; 100.2 and 117.3 microns3 resp. in case of b 93.4; 96.4 and 119.7 microns3.

Aging↗
PubMed1986

Candida glabrata meningitis.

We have reported an unusual case of Candida glabrata meningitis causing acute changes in mental status in a chronically ill, elderly patient with non-insulin-dependent diabetes mellitus. Candida glabrata was identified by Gram stain, culture, and fermentation pattern from the CSF. Although the patient died of foreign body aspiration, an excellent clinical response was initially obtained with amphotericin B and 5-flucytosine. This is the first report of a symptomatic Candida glabrata meningitis.

Aged↗
PubMed1986

[Removal of an intrauterine device (IUD) and uterine curettage. A report of experiences].

It is reported on 180 patients in whom IUD were removed with simultaneous dilatation and curettage of the uterus because of menstrual irregularities or a long indwelling of the IUD. In addition to the indwelling the age of the patients and the parity are analysed and a survey of the histological findings is given. We explain our position about the necessity of simultaneous D and C, ist risks and economical aspects.

Adult↗