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Biomedical subjects

R Baumgartner

Publications and source records attributed to R Baumgartner.

At least 199 records · Page 11Linked to original sources
PubMed1982

[Systemic reactions in rats following the initiation of a local inflammatory process by subcutaneous administration of spirits of turpentine].

Local inflammation was induced in rats by single (1 x 4 ml/kg) or multiple (14 X 0.2 ml/animal) infections of turpentine. The induction of inflammatory processes in both groups resulted in anemia and granulocytosis following an initial leukopenia. Thrombopenia on the second day, followed by thrombocytosis, was also observed in both groups. Studies on blood chemistry parameters revealed a decline in serum albumin; elevation of alkaline phosphatase in serum was observed only after multiple injection of turpentine. In these animals an elevation in the weights of spleen and adrenals and a reduction in the weight of thymus were also found.

Animals↗
PubMed1980

[Late results of traumatic separation of the upper femoral epiphysis as an obstetrical lesion (author's transl)].

Publications on birth-traumatic epiphyseolysis of the head of the femur are rare. No long-term reports (the course of the disease extending over 10 years and more) have been published. We must mention the detailed paper published by Mau in 1975 on epiphyseolysis of the head of the femur in children, among which a lesion of the epiphysis in an otherwise complicationfree birth is described. In most of the cases, however, epiphyseolysis occurs with breech presentation (Michail 1958, Mortens 1964), less frequently with Caesarean sections (Baumgartner 1961) and internal versions (Lindseth 1971). If the region of the hip joint appears swollen, associated with haematoma and pain on pressure-which can also occur in the region of the proximal femur, associated with shortening of the leg-then epiphyseolysis must be suspected. Clinical examination of the hip joint is characterized by pain inhibition. X-ray examination of the pelvis ante partum will mostly show lateral and cranial dislocation of the proximal shaft of the femur. Differential diagnosis of a dislocation of the hip joint is possible since symmetrical and well developed acetabulae are present. Diagnosis is finally established by means of arthrography of the hip. Likewise, callus formation supplies proof of the reparation processes subsequent to epiphyseolysis. Treatment in congenital that prescribed by the treatment guidelines in congenital hip dislocation. Abduction-extension is the method of choice. In order to improve reposition of the fragments, an additional internal rotary traction or transverse traction in the direction of adduction is recommended. However, in view of the rapidity of callus formation (approximately 2 weeks) and consolidation of epiphyseolysis, the effectivity of prolonged therapeutic efforts must be doubted if seen in retrospect. This applies mainly to subsequent Lorenz plaster-casts followed by the application of a splint. Several months will elapse until the child begins to stand and to walk, and during this period consolidation of the lysis may have easily taken place.

Adult↗
PubMed1980

Amputee stump radiology.

In patients with stump problems, radiological examination of the stump is desirable. To get a maximum of information, the X-ray technique has to be adapted to the qualities of the stump which are different from the corresponding part of a normal limb. Special techniques permit further diagnosis.

Amputation Stumps↗
PubMed1980

[Propionic acidemia associated with hypertrophic pyloric stenosis and bouts of severe hyperglycemia (author's transl)].

A newborn is presented with hyperexcitability, drowsiness and later-on with frequent vomiting and muscular hypotonia. Examination of the urine by gas chromatography-mass spectrometry lead to the diagnosis of propionic acidemia which was confirmed enzymatically in fibroblasts. Two unusual features were encountered in this case: There were severe bouts of hyperglycemia with blood glucose values up to 396 and 747 mg/100 ml; furthermore x-ray studies and autopsy revealed a hypertrophic pyloric stenosis.

Autopsy↗
PubMed1979

Propionyl-CoA carboxylase deficiency with overflow of metabolites of isoleucine catabolism at all levels.

An 11-year old girl with spastic paraplegia and mental retardation has suffered from attacks of metabolic acidosis since the age of 18 months. "Ketotic hyperglycinemia" was diagnosed when she was 3 years old. Reinvestigation at 9 1/2 years included a two-day load with L-isoleucine, and propionyl-CoA carboxylase assay in cultured fibroblasts. The following compounds increased following the load: 3-hydroxypropionic acid, 2-methyl-3-hydroxybutyric acid, 2-ethylhydracrylic acid, 3-hydroxy-n-valeric acid, 3-oxo-n-valeric acid, 2-methyl-3-oxobutyric acid, 2-oxo-3-methylvaleric acid, 2-methyl-3-oxovaleric acid, N-tiglylglycine, methylcitric acid and butanone. Small amounts of alloisoleucine appeared in plasma. Propionyl-CoA carboxylase deficiency was suggested by this metabolite pattern and demonstrated in cultured fibroblasts.

Acidosis↗
PubMed1979

Folate distribution in cultured human cells. Studies on 5,10-CH2-H4PteGlu reductase deficiency.

We have studied the distribution of folate coenzyme forms in cultured human fibroblasts from control lines and from lines derived from nine patients representing all of the published reports of 5,10-CH(2)-H(4)PteGlu reductase deficiency. Based on mobility on DEAE-Sephadex and differential microbiological assay the major folate fractions in extracts of human fibroblasts were 5-CH(3)-H(4)PteGlu, 10-CHO-H(4)PteGlu, and 5-CHO-H(4)PteGlu with smaller fractions, which included 5-CH(3)-H(2)PteGlu, 10-CHO-PteGlu, and H(4)PteGlu. Evidence that the 5-CHO-H(4)PteGlu may have been derived from 5,10-CH=H(4)PteGlu during extraction is presented. In most of the mutant fibroblasts the absolute concentration of 5-CH(3)-H(4)PteGlu was lower than in control cells but the proportion of intracellular folate which was 5-CH(3)-H(4)PteGlu was strikingly lower in mutant cells when determined by chromatography or differential microbiological assay. In both control and mutant cells most of the 5-CH(3)-H(4)-PteGlu was polyglutamate. The proportion of intracellular folate which was polyglutamate was similar in control and mutant cells. A direct relationship was observed between the proportion of cellular folate which was 5-CH(3)-H(4)PteGlu, and both the clinical severity of this disorder and the residual enzyme activity indicating that the distribution of different folates may be an important control of intracellular folate metabolism. These studies indicate that 5,10-CH(2)-H(4)PteGlu reductase is the only significant intracellular pathway for the generation of 5-CH(3)-H(4)PteGlu, that the activity of this enzyme regulates the level of this folate in control and mutant cells under conditions of culture used here, that the majority of intracellular folate is in the polyglutamate form, and that the relative distribution of folates may control folate metabolism by interaction in the various folate reactions.

Cells, Cultured↗