[Fever--treatment requiring symptom or meaningful defense reaction?].
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Biomedical subjects
Publications and source records attributed to R Baumgarten.
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The follow-up of serum immunoglobulin levels in patients with acute viral hepatitis B demonstrated a significant decrease of the IgG and IgM concentrations during the first 6-10 weeks of the illness in a group of 29 patients who resolved the disease. In contrary, similar changes could not be observed in 8 patients developing a chronic course of the disease with persistence of the HBsAg.
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The authors analyse the behaviour of the circulating immune complexes in acute virus hepatitides with and without HBs antigenaemia in correlation with the bilirubin level and the transaminases. No essential differences were found depending on the severity of the lesion of the liver parenchyma and on the proof of the HBs-antigen. Constantly increased immune complexes were found during the whole period of observation. It seems that 4 weeks after the beginning of the disease a normalisation of the immunogenic reactivity and an end of the elimination of the causative organism did not yet appear.
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The progression of acute viral hepatitis non-A, non-B in a group of young female patients with well defined disease was evaluated retrospectively over a period of 21/2 years. The histologically proved chronification rate was 39 per cent. It was looked for a correlation between some parameters in the acute phase of the disease, the distribution of HLA antigens, and the progression to chronicity. There were no statistically ensured differences of HLA antigens between patients with chronic hepatitis non-A, non-B, patients with healed acute one, patients with chronic hepatitis type B, and the normal population. The level of transaminases within the acute phase of the illness did not allow to draw any conclusion for the further progression of the disease. But icteric patients seemed to develop chronic disease more seldom. In this time, the reason of the high chronification rate after infection by hepatitis virus(es) non-A, non-B is not yet clear.
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By anamnestic inquiry and investigation for HBsAg and anti-HBs (RIA) of 120 staff members from 18 endoscopic centers, we found reference to remarkable spread of hepatitis B. Its incidence in endoscopic staff is unambiguously higher than in personal of internal wards. So, 8.3 per cent of endoscopic workers were positive for HBsAg, and anti-HBs was found in 29.7 per cent of them. This study accentuates the high danger by gastro-enterologic patients, who not rarely are HBsAg-positive and infectious. Preventive measures are recommended.
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