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Biomedical subjects

R Bauer

Publications and source records attributed to R Bauer.

At least 541 records · Page 30Linked to original sources
PubMed1976

[The effect of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate ((ipratropiumbromide) on tracheobronchial spasm, bronchial and salivary secretions, ECG and heart rate (author's transl)].

At very low doses (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropaniumbromide-(+/-)-tropate (ipratropiumbromide, Sch 1000, Atrovent) and atropine inhibit acetylcholine-induced bronchospasms in guinea-pigs and dogs. The dose ratio main effect vs. most sensitive side effect (inhibition of saliva secretion) is 1:10 for i.v. injection and 1:100 for aerosol application. When both compounds are administered in a nebulized form bronchodilatation occurs immediately. The maximum effect of Sch 1000 occurs somewhat later than that of atropine but the duration of action is much longer. Bronchial secretion in guinea-pigs is increased by small doses of Sch 1000 and atropine. These doses correspond to bronchodilating doses.

Acetylcholine↗
PubMed1976

[Bronchospasmolytic activity of aqueous aerosols in anesthetized dogs (author's transl)].

A modification of the method of Konzett and Rössler is described. This modification allows the administration of atomised drug solutions to anaesthetised dogs. Information is thus obtained on the bronchodilatory activity of a drug and the onset and duration of effect. Two anticholinergics (atropinsulfate and ipratropiumbromide) and three beta-adrenoceptor stimulants (isoprenaline, orciprenaline and salbutamol) were investigated. After local administration as aerosols the anticholinergics proved to be as potent or even more so than the beta-adrenoceptor stimulants.

Adrenergic beta-Agonists↗
PubMed1975

[The results of Chiari's medial displacement osteotomy].

Results of follow-up investigations on 45 patients with hip operated between 1968 and 1973 after the method of Chiari are reported by the authors. The post-operative development of the C.E. angle (Wiberg) and of the acetabular inclination angle (v. Lanz) are discussed. Attention is drawn to the necessity of X-ray films taken in a second projection (Fauxprofil view). With the aid of arthrography of the hip joint it is demonstrated that the most important demands of acetabulum formation surgery, namely the antomical congruence of the joint components, can be achieved by means of pelvic osteotomy after the method of Chiari.

Adolescent↗
PubMed1975

[The results of innominate osteotomy].

With the aid of radiological and clinical functional criteria, the results of 33 hip joints, operated after the method of Salter, are analysed. As in most cases a femoral detorsion occurs as a result of the pelvic osteotomy, basic coupling of the pelvic osteotomy with a femoral osteotomy dose not appear to be necessary. The importance of necessity of exact adherence to the principles of surgical technique, as described by Salter, as well as pre and post operative care, is stressed.

Child↗