Search PubMed⌕ Search

Biomedical subjects

R Bassleer

Publications and source records attributed to R Bassleer.

At least 37 records · Page 2Linked to original sources
PubMed1984

Antimitotic activity of strychnopentamine, a bisindolic alkaloid.

Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.

Alkaloids↗
PubMed1982

[Effects of cis-dichlorodiaminoplatinum II (cis-Pt II) on chromatin ultrastructure in animal or plant cells and repercussions on the cell cycle].

Cultivated animal cells (mouse peritoneal macrophages, chick fibroblasts or mouse Ehrlich tumor cells) or Zea mays root tips are treated with cis-Pt (II). Various effects (chromatin dispersion or condensation, pycnosis) are observed under some experimental conditions in all cell types. Cytoplasmic ribosomes in helical aggregates appear but only in vegetal cells. Mitosis and cell cycle disturbances due to cis-Pt (II) are probably related to chromatin alterations. We suggest that the latter and helical polyribosomes are produced by cis-Pt (II) reaction with nucleic acids in these structures.

Animals↗
PubMed1982

[Melanogenesis, an expression of the differentiation of cancer cells in culture].

In B 16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analysed by cytological and cytochemical methods. When cultured for long periods (several months), melanogenesis is expressed according to a cyclic way, even when maintained in a culture medium of constant composition and without adding any chemical agent eventually able to influence this phenomenon. This spontaneous cyclic activity is analysed and an explanation is given as an hypothesis.

Animals↗
PubMed1981

[Study of human synovial cells in culture].

Normal human synovial cells are cultivated in vitro; they actively multiply and fibroblast-like cells with structural characteristics of intermediate synoviocytes are obtained. In view of analyzing some functional aspects of this cell line, their endocytotic capacities have been studied. They also have been cultivated in a medium deprived of serum; a new cell type develops ("dendritic cells"). The latter are analyzed (cell division, endocytosis). As a comparison, human pulmonary fibroblasts (W I 38 line) and mouse macrophages are cultivated and studied under the same experimental conditions.

Culture Techniques↗
PubMed1978

Number of nucleoli in Ehrlich tumor cells during interphase.

Fractions of mouse Ehrlich ascites tumor cell populations with a high percentage of cell either in early or in late interphase were separated by centrifugation on ficoll gradients. Nucleoli were studied by light or electron microscopy in these cell subpopulations. It was shown that, in these cells, the number of nucleoli per nucleus does not vary significantly during interphase. This result is discussed and an anlysis of the relationships between the number and the volume of the nucleoli in these cells is present.

Animals↗
PubMed1978

[Peritoneal resorption of ethidium bromide, free or linked to DNA in rodents].

Ethidium bromide, either free (EB) or bound to DNA (EB-DNA), is injected into the peritoneal cavity of adult rats or mice. EB is then detected by fluorescence microscopy in peritoneal cells and by spectrophotometry in the peritoneal fluid. EB-DNA persists for a longer period of time in the peritoneal cavity than free EB does.

Animals↗
PubMed1977

[Comparison of the effects of ethidium bromide and of the ethidium bromide-deoxyribonucleic acid complex in Ehrlich tumor cells].

When injected into the peritoneal cavity, ethidium bromide can strongly inhibit the multiplication of mouse Ehrlich ascites tumour cells. This antitumour effect is increased when ethidium bromide is linked to DNA and also injected into the peritoneal cavity. The cellular alterations are identical after a treatment with E.B. either free or bound to DNA. However, when the cells are treated with E.B.-DNA they contain E.B. for a longer period than after a treatment with E.B.

Animals↗