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Biomedical subjects

R B Roy

Publications and source records attributed to R B Roy.

63 records · Page 4Linked to original sources
PubMed1967

The utilization of long nylon catheters for prolonged intravenous infusions.

A study of 300 patients receiving intravenous therapy showed that 90 had associated phlebitis. Because of this high rate of complications, the use of long plastic catheters, with the tip located in a large central vessel, was investigated. One hundred and one catheters were inserted into the basilic vein through a cut-down. The patients were divided into four groups: infusions lasting one to seven days, eight to 14 days, 15 to 28 days and 29 days or longer. The most common complication was obstruction of the catheter with clotted blood. In four patients the catheters had to be removed because of phlebitis; two were pulled out by the patients themselves. Infection was not observed. Two factors probably contributed to the successful infusions: the composition of the plastic catheters (nylon) and the location of the tip in a large central vessel.

Catheterization↗
PubMedDate not supplied

The M1 and Tm antigens require M and N gene-specified amino acids for expression.

It is known that the major red cell sialoglycoprotein (SGP) of M1 + red cells has the same amino acid sequence as M SGP, whereas that of Tm + cells has the same sequence as N SGP. M1 and Tm are serologically demonstrable when a substitution of N-acetyl-D-glucosamine for N-acetyl-neuraminic acid occurs in one or more of the alkali-labile tetrasaccharides bound at positions 2, 3, and/or 4 of M or N SGP, respectively. The authors used two serums containing anti-M and potent anti-M1 and two containing anti-Tm in tests for antibody crossreactivity and cross adsorption and in antibody inhibition studies. The distinct specificities of anti-M1 and anti-Tm, as determined by these studies, show that the M and N gene-specified amino acids are more important than the glycosylation change in the fine structure of M1 and Tm antigens.

Acetylglucosamine↗
PubMedDate not supplied

JMH variants: serologic, clinical, and biochemical analyses in two cases.

BACKGROUND: JMH is a high-frequency red cell blood group antigen that resides on a 76- to 80-kDa glycosylphosphatidylinositol-linked protein also known as CDw108. Antibodies with JMH specificity are often autoimmune and are usually, if not always, clinically benign. Some individuals with JMH-variant antigen produce alloantibodies to JMH, but little evidence concerning their clinical significance is available. This article reports on two patients who express a JMH-variant antigen and produced alloanti-JMH. STUDY DESIGN AND METHODS: Murine monoclonal antibodies and human antibodies to JMH were used in hemagglutination, radioimmunoassay, and Western blot testing of red cells from two JMH-variant patients; antiserum from one of these patients was also used in biochemical studies. In addition, in vivo survival of JMH-positive red cells was studied in the same patient. RESULTS: Biochemically, both examples of red cells with the JMH-variant phenotype expressed a JMH protein with a molecular weight similar to that of the normal JMH protein. For both patients, family studies suggested an autosomal recessive pattern of inheritance. Survival study demonstrated reduced in vivo red cell survival in one patient. CONCLUSION: JMH-variant phenotypes express a protein of normal molecular weight and are inherited in an autosomal recessive pattern. Furthermore, individuals with this phenotype can produce clinically significant antibodies.

Aged↗
PubMedDate not supplied

Practical models for the care of HIV and AIDS patients.

Mathematical models for infectious diseases are of limited use in providing practical help to health professionals. In this paper we discuss computer models developed jointly by operational research mathematicians and clinicians to meet this need. We use the term 'operational modelling' to describe this pragmatic approach. The models can aid decision-making at a resource planning level and can also be used by clinicians to monitor and improve patient care. The models incorporate uncertainty and variability and are therefore mathematically complex, but are easy to use and provide a great deal of useful information about morbidity and resource use.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Increased nail and hair growth in a patient with AIDS.

A variety of nail and hair changes have been described in AIDS patients, but rapid nail growth has not previously been reported. A slowing of nail growth would be expected in these patients due to immunosuppression and possible malnutrition. We report a case of increased nail and hair growth in a man with AIDS.

Acquired Immunodeficiency Syndrome↗