Biomedical subjects
Publications and source records attributed to R A Kaufman.
Congenital mesoblastic nephroma is the only primary renal neoplasm with radiographically demonstrable function. Renal function within two typical congenital mesoblastic nephromas was demonstrated by computed tomography in one case and renal scintigraphy in the other. Excretion of contrast medium and radionuclide was due to functioning nephrons trapped within the tumor.
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Three children with severe, secondarily infected atopic dermatitis since infancy developed osteomyelitis of the distal phalanges of the hands. The insidious onset of one or more distal subungual black macules was followed by edema, erythema, and pain in the involved fingers. No child had an elevated erythrocyte sedimentation rate or fever, but all had roentgenographic or scintigraphic evidence of bony destruction. In two children, Staphylococcus aureus grew from skin surface cultures; S aureus also grew from nail bed and osseous cultures of the distal phalanges; Streptococcus viridans grew from one child's nail bed. All children had prolonged hospitalizations. In two children, laboratory evaluation of immunologic function disclosed normal findings. We postulate that intense scratching of infected skin coupled with minor trauma to the fingertips created distal subungual microabscesses that spread contiguously to the underlying bone.
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A case of thoracic pedicle aplasia of T12 coincident with pedicle hypoplasia at T11 is reported. The authors review the literature on thoracic pedicle deficiency and discuss the computed tomography (CT) findings in the thoracic pedicle aplasia/hypoplasia spectrum.
Thirteen orbital computed tomographic (CT) scans were obtained in 12 patients with postseptal (orbital) cellulitis. Sinus radiographs, which were also obtained, were not helpful in diagnosis or management. The location and extent of the inflammatory process was accurately demonstrated with axial CT scans in all cases. A protocol using CT in the management of postseptal cellulitis is proposed.
Infantile-onset multisystem inflammatory disease (IOMID) is a newly recognized disease that is similar to systemic-onset juvenile rheumatoid arthritis (JRA). The clinical symptoms of IOMID include rash, fever, lymphadenopathy, chronic meningitis, uveitis, and a distinct arthropathic condition. Skeletal involvement is surprisingly constant. The long bones become short, bowed, and widened. The metaphyses flare and simulate rickets. Grotesque epiphyses appear fragmented early in the course of the disease but are gradually incorporated into the widened shafts. We observed these and other radiologic findings in the four cases described in the present study. The findings are distinctive and allow for a specific diagnosis.
Cranial computed tomographic (CT) findings are described in 37 children with head injuries resulting from physical abuse. CT findings included subarachnoid hemorrhage (27 patients), cerebral edema (24), cerebral hemorrhage (11), and subdural hematoma (nine). Intravenous contrast material was administered in 10 children in whom there were neurologic symptoms or signs but no history or physical signs of trauma or abuse. In five of these children, increased vascularity was seen in areas that later showed infarction. Eight children were studied by both CT and sonography. Sonography detected 50% fewer abnormalities than did CT. It was found that children with skull fracture had the same range of injuries as children without fracture, and they had a higher incidence of subarachnoid hemorrhage. In acutely traumatized children, cranial CT should be the method of choice to provide the most accurate diagnosis and documentation of injury. Skull radiographs should also be obtained because they sometimes show fractures not recognized by CT.