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Biomedical subjects

R A Brumback

Publications and source records attributed to R A Brumback.

At least 127 records · Page 7Linked to original sources
PubMed1982

Right hemisphere involvement in learning disability, attention deficit disorder, and childhood major depressive disorder.

Learning disability, attentional disorder and childhood major depression are frequent diagnoses in children with behavioral disturbances and impaired school performance. All three disorders are associated with right cerebral hemisphere dysfunction. Anatomical disturbance of right hemisphere function results in learning disability and/or attentional disorder. The physiological disturbance of right hemisphere function produced by a major depressive episode results in additional learning disability and/or attentional disorder.

Attention↗
PubMed1982

Reduplicative paramnesia: a disconnection syndrome of memory.

A case of post-traumatic reduplicative paramnesia (Capgras syndrome) is presented in which the patient experiences duplications in all three spheres of orientation (time, place, person). We postulate that these duplications are the result of a disconnection of new memory registration from past memory stores. The patient is unable to integrate present cues with premorbid experience, and bases judgments of his present orientation upon recollections from the past. A deep lesion at the right posterior hippocampus and temporo-parieto-occipital junction is suggested as the site of this postulated primary memory disconnection, based upon neuropsychological testing and CAT scan results. This right temporal atrophy and memory disconnection appears to have induced immature personality changes.

Adult↗
PubMed1982

The electroencephalographic pattern during electroconvulsive therapy II. Preliminary analysis of spectral energy.

Computer assisted energy-spectral analyses were obtained on EEG recordings of unilateral non-dominant hemisphere ECT-induced seizures using the different pre-ECT anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketalar). The previously postulated predominance of electrical energy over the stimulated (right) hemisphere early in ECT-induced seizures is confirmed. There appears to be marked reduction in total seizure energy with methohexital anesthesia, whereas ketamine anesthesia appears to be associated with increased overall seizure energy. The greatest right to left energy transfer during the seizure occurred with Innovar anesthesia.

Adult↗
PubMed1982

An hypothesis regarding the commonality of right-hemisphere involvement in learning disability, attentional disorder, and childhood major depressive disorder.

Learning disability, attentional disorder, and childhood major depression are frequent clinical diagnoses for children who show behavioral disturbances and impaired school performance. We suggest that all three of these conditions may be associated with dysfunction of the right cerebral hemisphere. Anatomical disturbance of right-hemisphere function is often associated with learning disability or attentional deficits. The physiological disturbance of right-hemisphere function by a major depressive episode may produce or exacerbate learning disability or attentional disorder.

Attention↗
PubMed1982

Use of strontium as the capture ion in adenyl cyclase histochemical staining of skeletal muscle.

Histochemical staining of adenyl cyclase was performed in muscle specimens. Adenylyl imidodiphosphate (AMP-PNP) was used as the reaction substrate and strontium was used as the capture ion for the liberated phosphate. Staining appeared in the vascular structures between muscle fibers and between muscle fascicles. Substituting lead for strontium as the capture ion resulted in loss of the staining of small vessels between muscle fibers, while indistinct staining of larger vascular structures between muscle fascicles was preserved.

Adenylyl Cyclases↗
PubMed1981

Myotonic dystrophy as a disease of abnormal membrane receptors: an hypothesis of pathophysiology and a new approach to treatment.

Muscle weakness, clinical myotonia, and multiple systemic organ disturbances characterize myotonic dystrophy. Many of these systemic disturbances involve target organ insensitivity to aminergic or peptidergic (hormonal) stimulation. Reduced density or impaired function of aminergic and peptidergic (hormonal) receptors throughout the body may underlie this disorder. Tricyclic antidepressant augmentation of aminergic function ameliorates depressive symptoms, increases strength, and improves clinical myotonia in myotonic dystrophy patients.

Antidepressive Agents, Tricyclic↗