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Biomedical subjects

R A Bornstein

Publications and source records attributed to R A Bornstein.

101 records · Page 6Linked to original sources
PubMed1982

Reliability of the Speech Sounds Perception Test.

Several studies have examined the test-retest reliability of the Halstead-Reitan battery of which the Speech Sounds Perception Test is one component. However, there are no data on internal reliability. Clinical experience with the test suggests that the subtests are not equally difficult. The present study examined the internal reliability in two independent samples (ns = 106 and 81). In both samples, a significantly greater number of errors was found on the first half of the test. Also in both samples, the largest number of errors occurred on Subtests B and A, while the fewest errors were found on Subtests E and D. The split-half reliability coefficients for the two samples were .74 and .87. There was also some tentative support for the use of an abbreviated version. A formula was generated (Series A + Series B + Series C + 2) which correctly classified a high percentage of patients in both samples (96% and 90%) using performance above and below the conventional cutoff score of eight errors.

Adolescent↗
PubMed1981

Neuropsychological changes following carotid endarterectomy.

Fifty-five subjects undergoing carotid endarterectomy were grouped according to side of operation, i.e. right, left and bilateral. There subjects were administered a comprehensive neuropsychological battery prior to and six months following surgery. The performance of these subjects was compared with a control group undergoing surgical procedures that did not involve the brain or cerebral vasculature, and a second control group composed of patients with cerebrovascular symptoms who were not operated. It was found that as a group the endarterectomy subjects improved on a greater percentage of measures. When various subgroups were examined, it was found that the right operated stroke patients improved on significantly more measures than any other group. The difference between right and left stroke patients was significant, but there was no difference between right and left TIA patients in the extent of improvement. These findings were discussed in terms of possible underlying mechanisms.

Adult↗
PubMedDate not supplied

Patterns of obsessive compulsive symptoms in Tourette subjects are independent of severity.

Studies have examined the expression of obsessive compulsive (OC) symptoms in obsessive compulsive disorder (OCD), OCD with co-occurring Tourette's Syndrome (TS) or chronic motor tic disorder (CMT) and TS alone. In adult samples, there appears to be a relatively consistent OC symptom thematic content that characterizes OCD alone and OCD in conjunction with tics or TS. Previous studies have controlled for the severity of OC symptoms in OCD and TS groups. In the current study, it was our objective to determine whether patterns of OC symptoms in TS are independent of OC symptom severity. The current exploratory study examined OC symptom expression in a nonclinically based TS sample with a broad range of OC symptoms and severity and a selected clinical OCD sample without TS/tics. Univariate and multivariate statistical analysis explored patterns of OC symptom expression between the two groups. Similar to previous reports examining OC symptoms in OCD and OCD with TS/tics, subjects with OCD alone were characterized by contamination obsessions and cleaning compulsions. In contrast, TS subjects had more somatic, sexual and symmetry obsessions and more checking, counting and touching/blinking compulsions, independent of OC symptom and tic severity. A discriminant function using obsessive items alone correctly grouped 91.4% of cases. The current study replicates patterns of OC symptom expression unique to OCD alone. Patterns of OC symptoms, in particular obsessive symptoms, can robustly predict membership in OCD or TS groups, even with a substantial variation in OC symptom severity as measured by the Y-BOCS score.

Adult↗
PubMedDate not supplied

Urinary excretion of MHPG and normetanephrine in attention deficit hyperactivity disorder.

Twenty-four-hour excretion (expressed per gram of creatinine) of the norepinephrine metabolites 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and normetanephrine (NME) was measured in children with attention deficit hyperactivity disorder (ADHD) and in normal subjects matched for age and education. In contrast to findings with Tourette syndrome patients, in the ADHD patients there was no significant difference in excretion of MHPG and NME from control values.

Attention Deficit Disorder with Hyperactivity↗
PubMedDate not supplied

Psychopathology in human immunodeficiency virus infection: lifetime and current assessment.

The present study determined lifetime and current psychiatric functioning in a sample of homosexual or bisexual men at various stages of human immunodeficiency virus (HIV) infection in order to address several questions regarding the relationship between psychopathology and HIV infection. HIV+ asymptomatic or symptomatic and HIV- homosexual or bisexual men completed self-report measures of psychological and health functioning and participated in structured diagnostic interviews. Additional information regarding HIV-related life events and their potential relationship to onset of disorder and family history of psychiatric disorder were obtained. A high lifetime prevalence of affective and substance use disorder was found, with almost one half of the sample meeting criteria for both disorders. Lifetime affective disorder diagnosis was associated with a positive family history of affective disorder. HIV-related events were most closely associated with onset or recurrence of affective disorder compared with other disorders. Low current rates of psychiatric disorder and levels of emotional distress were found, with no differences in degree of psychiatric adjustment across stage of infection. We conclude that the lifetime prevalence of certain categories of psychiatric disorder is high in both HIV+ and HIV- homosexual samples. Increased rates of psychiatric disorders do not appear to be a consequence of HIV infection. However, episodes of illness, particularly affective disorder, may develop following an HIV-related event such as confirmation of infection. Although symptomatic subjects have more somatic difficulties, there appears to be no relationship between stage of illness and level of emotional distress.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

Obsessive characteristics in subjects with Tourette's syndrome are related to symptoms in their parents.

The symptom characteristics of two Tourette's syndrome (TS) subgroups formed on the basis of their parents' obsessive-compulsive (OC) symptomatology were explored. TS subjects with parents having OC symptoms had significantly more OC symptoms and complex tics and a later age of symptom onset than the balance of the TS cohort. These findings suggest an association between parental OC symptoms and OC symptoms in their TS offspring.

Adolescent↗
PubMedDate not supplied

Clinical predictors of psychopathology in children and adolescents with Tourette Syndrome.

Tourette Syndrome (TS) is a neuropsychiatric disorder of childhood onset characterized by vocal and motor tics and associated psychopathologies. The current study was undertaken to explore the associations between tic symptomatology, related clinical variables and behavioral dysfunction within a cohort of TS subjects. Ninety-two child and adolescent TS subjects were rated through self-measure, and by parents on measures of tic symptomatology, OC characteristics, and dysfunctional behaviors including learning difficulties and attention deficits. Statistical modeling revealed associations among tic clusters, clinical items and behavioral measures, which were unique for the child and adolescent subgroups.

Adolescent↗
PubMedDate not supplied

WAIS-R factor structure in epileptic patients.

The Wechsler Adult Intelligence Scale--Revised (WAIS-R), the newest version of the Wechsler Scales, has had several factor analytic studies, but none have been done in a sample of seizure-disorder patients. The factor structure of the WAIS-R was examined in this study in a sample of 107 patients with various seizure disorders. The results of this study revealed the 3-factor solution, as has been reported in many previous studies. The most notable difference was the relatively greater prominence of the Freedom from Distractibility factor. These results are consistent with studies of the factor structure of previous editions of the Wechsler Scales in samples of epileptic patients. The relative prominence of the Distractibility factor could suggest that attentional factors are a more important influence on performance than in other patient groups. Further studies are needed to clarify the effect of various seizure-related variables on patterns of intelligence.

Adolescent↗
PubMedDate not supplied

Depression accounts for executive function deficits in obsessive-compulsive disorder.

OBJECTIVE: To examine the relative impact of depression on executive function deficits in obsessive-compulsive disorder (OCD). BACKGROUND: Existing data suggest that OCD is associated with basal ganglia and orbital frontal dysfunction, and neurobehavioral abnormalities that are putatively associated with these regions have been demonstrated in OCD. Nonetheless, few studies have accounted for the effects of depression, which is a common concurrent symptom among those with OCD. METHOD: A broad battery of neuropsychological tests, including measures of executive function and sensory-motor function, was administered to 20 adults with OCD and 31 control subjects. To assess depressive severity, participants were administered the depression scale from the Minnesota Multiphasic Personality Inventory. RESULTS: Data were analyzed using a regression model in two steps. In step one, patient group was entered, and patients with OCD demonstrated a pattern of executive function and sensory-motor deficits, similar to those shown in previous research. In step two, self-reported depressive symptom severity was entered as a predictor. As a consequence, depression accounted for some executive function deficits, whereas presence of OCD only predicted performance on measures of sensory-motor function. CONCLUSIONS: These data suggest that abnormalities involving executive function in OCD are related to co-morbid depressive severity. However, sensory-motor deficits seem to be more consistent with basal ganglia/orbital frontal dysfunction in OCD.

Adolescent↗
PubMedDate not supplied

MR of head and neck adenopathy in asymptomatic HIV-seropositive men.

PURPOSE: Adenopathy is a well-known component of AIDS-related complex. Our goal was to determine whether asymptomatic HIV-infected persons have characteristic findings of head and neck adenopathy on MR imaging and whether there is an association between the MR findings and the CD4 lymphocyte counts. METHODS: We blindly and retrospectively evaluated the distribution and size of lymphadenopathy seen on screening MR examinations that were performed on 50 asymptomatic HIV-positive male subjects and 50 age-matched HIV-negative control subjects. We also correlated the imaging findings in HIV-seropositive and -seronegative subjects with their CD4 counts. RESULTS: The HIV-positive subjects had a higher incidence of adenopathy compared with the controls. Statistically significant differences were found between the groups in size and number of neck lymph nodes, thickness of the adenoids, size of high, deep cervical-retropharyngeal lymph nodes, and presence of parotid abnormalities. We found a correlation between increasing lymph node size and decreasing CD4 levels. CONCLUSION: We conclude that HIV-positive asymptomatic patients have a high incidence of head and neck abnormalities including lymphadenopathy, and alteration in their CD4 counts not commonly seen in seronegative control subjects.

Adult↗