Biomedical subjects

Quan Zhang

Publications and source records attributed to Quan Zhang.

At least 73 records · Page 4Linked to original sources

PubMed2003

[Correlation between expression of p53 and prognosis of laryngeal squamous carcinoma].

BACKGROUND & OBJECTIVE: p53 expression was a marker to predict the poor prognosis of laryngeal cancer. Detection of p53 in the pathological negative margin can be used to find more patients with poor prognosis. The aim of this study was to reveal the correlation between p53 expression and prognosis in primary cancer and surgical margin of laryngeal squamous cell carcinoma (SCC). METHODS: The clinical data of 67 laryngeal SCC with pathological negative margin were analyzed retrospectively. The expression of p53 protein in the margin and primary cancer was detected by immunohistochemistry. The survival rates and the recurrent rates were compared between p53 positive and negative group both in surgical margin and primary cancer. RESULTS: (1) The positive rates of p53 in surgical margin and primary cancer were 19.4% (13/67) and 50.7% (34/67), respectively. (2) The recurrent rate of positive margin group was higher than that of negative margin group (69.2% vs. 33.3%, P = 0.018). The survival rate of positive margin group was lower than that of negative margin group (24.62% vs. 75.69%, P = 0.0012). The recurrent rate of p53 positive primary cancer was higher than that of p53 negative primary cancer (64.7% vs. 15.2%, P = 0.0000). The survival rate of p53 positive primary cancer was lower than that of p53 negative primary cancer (42.86% vs. 90.86%, P = 0.0000). CONCLUSION: The prognosis of those with p53 protein positive in the pathological margin or the primary cancer were worse than that of the negative group.

Adult↗

PubMed2003

[Multivariate analysis for prognostic predictors in the cN0 squamous cell carcinoma of the tongue].

BACKGROUND & OBJECTIVE: There is controversy in therapy strategy for the cN0 squamous cell carcinoma of the tongue. The aim of this study was to explore the relative factors of prognosis for the cN0 squamous cell carcinoma of the tongue and to identify the risk population. METHODS: Cox regression model was used to analyze the clinical data of 109 patients with cN0 tongue cancer treated in Cancer Center, Sun Yat-sen University from January 1990 to March 1998. The prognostic index (PI) of the patients was calculated on basis of the results of multivariate analysis. According to the individualized PI, the patients were classified to different hazard groups. RESULTS: The 3, 5 years survival rates were 74.40%and 69.31%, respectively. Multivariate analysis showed the prognosis statistically correlated with T grade, therapy manner of primary tumor, differentiation grade, age, and occult neck lymph node metastasis. T stage was found to be the most important prognostic factor. The prognosis of the patients in comprehensive therapy group is better than that in surgery alone group, chemotherapy alone,or radiotherapy alone group. The patients with tongue carcinoma in low differentiation group, the older group, or occult neck lymph node metastasis group showed a poor prognosis. The patients were divided into high-risk group,moderate-risk group, and low-risk group according to the PI value and there was significant difference in the survival rates between each two groups of the three groups (P< 0.05), and the 5-year survival rates were 83.33%, 64.12%, and 27.65%, respectively. CONCLUSION: The prognosis of cN0 squamous cell carcinoma of the tongue is associated with T grade, therapy manner of primary tumor, differentiation grade, age, and occult neck lymph node metastasis. PI value could be used to predict the prognosis of the patients with the cN0 squamous cell carcinoma of the tongue.

Adult↗

PubMed2003

[Regularity and therapeutic strategy of cervical lymph node metastasis in squamous cell carcinoma of the tongue].

BACKGROUND & OBJECTIVE: At present, whether neck dissection should be employed in squamous cell carcinoma (SCC) of the tongue with clinically node negative neck(cN0) is still controversial. This study was designed to explore the regularity of cervical lymph node metastasis in SCC of the mobile part of the tongue, and to discuss the theories and principles of employment of selective neck dissection in cN0 cases. METHODS: A retrospective research was performed on clinical data of 214 cases of SCC of the tongue treated with surgery from 1991 to 1997. Distribution of cervical lymph node metastasis of cN0 pN(+)= (pathologically node positive) and cN(+) (clinically node positive) pN(+)= cases were analyzed; the survival rates of different groups were compared; the factors that impact the survival of SCC of the tongue were screened out by Cox regression analysis. RESULTS: Cervical lymph node metastases were found in 69 cases. The metastatic rate was 32.2%. Metastases occurred in level I, II, III, IV, V of the ipsilateral neck were 22.3%, 33.5%, 22.3%, 4.6%, 1.0%, in level I,II,III, IV,V of the contralateral neck were 6.6%, 3.6%, 3.0%, 2.0%, 0.5%, respectively. The 5-year survival rates of the pN(+)= group and the pN0 group were 47% and 83%, respectively(P< 0.001). T stage and N stage were independent factors that impact the long-term outcome of SCC of the tongue. CONCLUSION: Level I,II,III of the ipsilateral neck tend to be involved when cervical lymph node metastases occur. Selective neck dissection can be used to treat the cervical metastasis in cN0 cases, as well as to evaluate the cervical lymph node status in order to determine whether comprehensive neck dissection should be employed.

Adult↗

PubMed2003

[Optimized methods of sentinel node localization in cN0 tongue carcinoma].

BACKGROUND & OBJECTIVE: At present, there is no clinical examination and biochemical marker available to assess the lymph node status of tongue carcinoma with clinically negative neck (cN0) accurately. Therefore, the treatment of the cN0 neck in tongue carcinoma is of blind to some extent. Application of sentinel node(SN) biopsy may possibly bring about the individualized management of the cN0 neck of tongue carcinoma. This study was designed to assess whether lymph node status can be accurately evaluated by SN biopsy and to screen out the optimized sentinel node localization method. METHODS: Preoperative nuclear lymphoscintigraphy and intraoperative methylene blue dye mapping were performed in 24 cases of tongue carcinoma to reveal the efficacy of sentinel node biopsy in evaluating the lymph node status in cN0 tongue carcinoma. Shortcomings and advantages of lymphoscintigraphy, methylene blue dye mapping and combination of both methods were discussed. RESULTS: Sentinel nodes were detected in all cases with both methods. Sentinel nodes were found with metastasis in 4 cases. No non-sentinel node was found with metastasis while sentinel nodes were pathologically negative. The detection rates were 3.5 sentinel nodes per case by lymphoscintigraphy, and 2.7 by methylene blue dye, while only 2.2 sentinel nodes by combined methods. CONCLUSION: Either lymphoscintigraphy or methylene blue dye mapping can be used to assess the cervical lymph node status of cN0 tongue carcinoma accurately. Combination with both methods is the most efficient and practicable method in sentinel node detection.

Adult↗

PubMed2003

[Quantitative analysis of HBV DNA amplified products with microtiter hybridization].

BACKGROUND: To establish a new assay for detecting the quantity of HBV DNA with PCR and enzyme-linked immunosorbent assay(ELISA). METHODS: The products of PCR using primers pre-labeled with biotin were hybridized with the capture probes that were immobilized on the microtiter strips and then bond with Sav-Ap. The quantity of DNA was detected by measuring the yellow color at 405 nm wave length. RESULTS: Totally 125 sera from patients with hepatitis B were tested for HBV DNA by this method,the sera were also tested for HBV immunological markers by solid phase radio immuno-assay (SPRIA). The HBV positive rate with PCR-ELISA was 64.9% (24/37) in samples which were positive for HBsAg, HBeAg and HBcAb; and 34.2% (13/38) in sera which were positive for HBsAg, HBeAb and HBcAb; in sera positive for HBsAg and HBcAb or only HBcAb, the positive rate was 6.7% (1/15) and 5.9% (2/34) respectively. CONCLUSIONS: The PCR ELISA assay is simple and suitable for clinical laboratory in quantitative determination of HBV DNA.

DNA Probes↗

PubMed2003

[Distant metastases and their significant indicators in laryngeal cancer].

OBJECTIVE: To investigate the factors on distant metastases (DM) of laryngeal cancer. METHODS: 277 cases of laryngeal cancer hospitalized in Cancer Center of Sun Yat-sen University from 1990 to 1995 were reviewed. 18 cases with DM were investigated to confirm the distant metastatic rate, target organ, time interval, and prognosis. Kaplan-Meier and Cox model analysis were used to find the significant indicators for DM in laryngeal cancer. RESULTS: The overall incidence of DM in laryngeal cancer was 6.5% (18/277). The target site of DM was mainly in lung 83.3% (15/18), liver 16.7% (3/18). 3 cases with DM in lung also combined with bone metastases which occurred in vertebra 1, lib 1 and 1 in multi-sites. 2 patients were diagnosed DM when admitted, and the rest with time interval between 1 and 103 months (median 7 months). The 3-year and 5-year cumulative survival in laryngeal cancer with DM was 23.8% and 11.9% respectively. The time interval between the presentation of DM and death was 2.77 months (median 4.6 months). The worst prognosis is liver metastasis with which the patient could survive 4.6 months at most in our study. Kaplan-Meier analysis in 277 laryngeal cancers showed that pathology, pathological differentiation of squamous cell carcinoma, N stage, and clinical stage were significant indicators for DM from laryngeal cancer. Cox model analysis showed that only N stage was the significant prognostic factor for DM in laryngeal cancer (Wald = 7.889, P = 0.005). CONCLUSION: Laryngeal cancer has certain percentage of DM, which is mainly in lung and their prognosis is usually poor. Non-squamous cell carcinoma, low pathological differentiation, cervical metastasis and advanced cancer are the possible indicators for DM, but our study shows that only N stage significantly predicts DM from laryngeal cancer.

Aged↗

PubMed2003

[Effectiveness evaluation and prognostic factor analysis in patients with minor salivary gland carcinoma of the hard palate].

BACKGROUND & OBJECTIVE: Minor salivary gland carcinoma of the hard palate is rare, and its long-term survival rate is high, making it difficult to evaluate the prognostic factors and the efficacy of treatment. This study was designed to evaluate the efficacy of treatment and investigate the prognostic factors of minor salivary gland carcinoma of the hard palate. METHODS: Ninety-six cases of minor salivary gland carcinoma of the hard palate hospitalized in Cancer Center, Sun Yat-sen University, from 1964 to 2001 were reviewed retrospectively. The cumulative survival rate was analyzed by Kaplan-Meier method. The factors were compared using the log-rank test. The influencing factors were screened by Cox proportional hazards model. RESULTS: The 5- and 10-year overall survival rates were 65.60% and 47.90%, respectively. The 5- and 10-year disease-specific survival rates for the patients treated with surgery (53 cases) and surgery + radiotherapy (35 cases) were 73.14%, 67.40% and 66.58%,46.60%,respectively. Multivariate analysis showed that age >or=50 years old,tumor size >or=3 cm,surgical margin status,and recurrence were independently associated with decreased survival rates (P< 0.05). CONCLUSION: Surgery or surgery dominated multi-modality therapy was the principal treatment modality for minor salivary gland carcinoma of the hard palate. Age >or=50 years old, tumor size >or=3 cm, surgical margin status, and recurrence are independent factors affecting the prognosis.

Adolescent↗

PubMed2002

Reduction in amounts of mitochondrial DNA in the sperm cells as a mechanism for maternal inheritance in Hordeum vulgare.

It is known that extranuclear organelle DNA is inherited maternally in the majority of angiosperms. The mechanisms for maternal inheritance have been well studied in plastids but not in mitochondria. In the present study we examined the mitochondrial DNA in the male reproductive cells of Hordeum vulgare L. by immunoelectron microscopy. Our results show that the number of anti-DNA gold particles on sections of sperm cell mitochondria decreased by 97% during pollen development. The reduction occurred rapidly in the generative cells and subsequently in the sperm cells, concomitant with a remarkable reduction in mitochondrial volume. It seems that the copy numbers of mitochondrial DNA were reduced in the male reproductive cells, which may be a possible mechanism by which paternal transmission is inhibited. Unlike mitochondria, plastids are excluded from the generative cells during the first pollen mitosis. These data suggest a mechanism for maternal inheritance of mitochondria in angiosperms and for independent control of inheritance of mitochondria and plastids in H. vulgare.

DNA, Mitochondrial↗

PubMed2002

Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.

A series of new chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized in an attempt to fabricate modulators with enhancing drug-resistant reversing efficacy and minimal side effects. Four aromatic amine ring systems-phenothiazine, iminodibenzyl, iminostilbene, and diphenylamine-were examined. Various tertiary amino groups including either noncyclic or cyclic aliphatic amines were introduced to explore the steric tolerance at the end of the side chain. The new compounds showed better drug-resistant reversing activity in chloroquine-resistant than in mefloquine-resistant cell lines and were generally more effective against chloroquine-resistant P. falciparum isolates from Southeast Asian (W2 and TM91C235) than those from South America (PC49 and RCS). Structure-activity relationship studies revealed that elongation of the alkyl side chain of the molecule retained the chemosensitizing activity, and analogues with four-carbon side chains showed superior activity. Furthermore, new modulators with phenothiazine ring exhibited the best chemosensitizing activity among the four different ring systems examined. Terminal amino function has limited steric tolerance as evidenced by the dramatic lose of the modulating activity, when the size of substituent at the amino group increases. The best new modulator synthesized in this study possesses all three optimized structural features, which consist of a phenothiazine ring and a pyrrolidinyl group joined by a four-carbon alkyl bridge. The fractional inhibitory concentration (FIC) index of the best compound is 0.21, which is superior to that of verapamil (0.51), one of the best-known multi-drug-resistant reversing agents. Some of the analogues displayed moderate intrinsic in vitro antimalarial activity against a W-2 clone of P. falciparum.

Animals↗

PubMed2002

Temperature-modulated carcinogenicity of 7,12-dimethylbenz[a]anthracene in rainbow trout.

Temperature-modulated hepatic disposition, covalent binding of radiolabeled genotoxin to hepatic DNA, and cancer incidence in rainbow trout (Oncorhyncus mykiss) were assessed after a single exposure to 7,12-dimethylbenz[a]anthracene (DMBA). Fish (2 g) were acclimated at 10, 14, or 18 degrees C for 1 mo and then exposed to 1 ppm DMBA in their water for 20 h. Exposures were at respective acclimation temperatures, or 10 and 18 degrees C acclimated fish were shifted to 14 degrees C for DMBA exposures. After 4 but not 20 h of exposure, hepatic [(3)H]DMBA equivalents increased with temperature for fish exposed at their respective acclimation temperatures (10 or 18 degrees C). Covalent binding of [(3)H]DMBA to hepatic DNA was similar after 3 d in fish exposed at their respective acclimation temperatures. However, in fish exposed at 14 degrees C, after 3 d the concentration of [(3)H]DMBA covalently bound to hepatic DNA was higher in 10 degrees C than 18 degrees C acclimated fish. After 21 d, covalent binding of [(3)H]DMBA to hepatic DNA was less persistent in 18 degrees C than 10 degrees C acclimated, exposed, and reared fish. There were no differences between temperature-shifted groups at that time. Temperature effects on tumor incidence were assessed 9 mo after DMBA waterborne exposures in fish that were reared at (1) their respective acclimation and exposure temperatures, (2) 14 degrees C after exposure at their respective acclimation temperature, and (3) 14 degrees C after 14 degrees C exposures. Incidence of stomach, liver, and swimbladder cancer increased dramatically with rearing temperature. Differences in tumor incidence were less marked in fish reared at the same temperature (14 degrees C). A strong negative correlation between liver tumor incidence and persistence of [(3)H]DMBA equivalents covalently bound to hepatic DNA suggested increased error-prone DNA repair at warmer temperature played an important role in increased tumor incidence.

9,10-Dimethyl-1,2-benzanthracene↗

PubMed2002

[Indication and clinical radical effect of functional neck dissection for head and neck neoplasm].

BACKGROUND & OBJECTIVE: The functional neck dissection was first described by Bocca in 1967. It has been used on clinical practice for years. But still controversial between supporters and opponents of functional neck dissection. This study was designed to evaluate application and radical effectiveness of functional neck dissection(FND). METHODS: One hundred and fifty-two cases underwent FND were reviewed with analysis of pathological specimen and follow-up data. RESULT: One hundred and fifty-two cases of FND include tongue carcinoma 20 cases, larynx carcinoma 23 cases, thyroid papillary adenocarcinoma 96 cases, follicular adenocarcinoma 9 cases, medullary adenocarcinoma 4 cases; Five years recurrence rate of tongue and larynx carcinoma was 12.5%, 14.3%, 40.0% and 20%, 16.7%, 50.0% in N0, N1, N2, respectively. 5 years recurrence rate of thyroid papillary adenocarcinoma is 6.5%, 7.1% in N1a, N1b, respectively. CONCLUSION: Functional neck dissection is suitable for head and neck neoplasm, was result in satisfactory radical effects.

Adenocarcinoma, Follicular↗

PubMed2002

[Surgical margin to direct the treatment and predict the prognosis of laryngeal carcinoma after partial laryngectomy].

BACKGROUND & OBJECTIVE: The surgical margin is very important for laryngeal carcinoma treatment. To preserve more laryngeal tissue can give patients good function, however, which increase the rate of positive surgical margin and recurrence. The correct surgical margin is benefit for laryngeal carcinoma patients' prognosis. This study was designed to investigate the value of surgical margin to direct the treatment of laryngeal carcinoma after partial laryngectomy and to evaluate the prognosis of laryngeal carcinoma. METHODS: The authors studied 115 cases of laryngeal carcinoma in which surgical margin samples were harvested during partial laryngectomy. The recurrence rate and survival curve of the positive and negative margin group were compared; The survival curve between the groups with and without postoperative radiotherapy both in negative margin group and positive margin group were also compared. RESULTS: The results of the negative group were better than that of the positive group: recurrence rate was higher (28.0% Vs 7.8% P = 0.006), the survival curve was better(P = 0.0241); The survival curve of those with positive surgical margin, at the same time, treated by postoperative radiotherapy was better than that of those without postoperative radiotherapy (P = 0.0046); but in negative group, the survival curve of those who treated with or without postoperative radiotherapy or not was different insignificantly (P = 0.0829). CONCLUSIONS: The prognosis of the positive margin group of laryngeal carcinoma was waster than that of the negative group, but it can be improved partially by postoperative radiotherapy. The best way to improve the prognosis was dissect entirely; There is not necessary to treat negative group by postoperative radiotherapy.

Adult↗

PubMed2002

[Clinical value of inducing chemotherapy for patients with advanced tongue cancer].

BACKGROUND & OBJECTIVE: It was reported that inductive chemotherapy play an important rolc in malignant tumors of head and neck. The aim of this study was to evaluate the role of the inductive chemotherapy in the treatment of advanced tongue cancer. METHODS: Eighty-three cases with advanced tongue squamous cell carcinoma were treated in our hospital from Jun 1989 to Dec 1995, divided two groups. Thirty-two cases were treated by surgery alone, and fifty-one cases were treated by surgery with preoperation, inducting chemotherapy including twenty-seven cases treated by bleomycinA5 alone, thirteen cases treated by combination chemotherapy(DDP, 5-FU, BLM), and eleven cases treated by lingual artery chemoembolization. RESULTS: Three and five-year survival rates in surgery group and multidisciplinary management group were 50%, 46.7% and 60.6%, 50% respectively. Their recurrence rates were 31.3% and 39.2% respectively. CONCLUSIONS: Combined management of advanced tongue cancer could not prolong the three and five years survival time, but it could increase loco-regional tumor control rate and prolong the disease-free survival and improve the quality of life.

Adult↗

PubMed2002

[Rule of lymph node metastasis in the cancer of mouth floor and its treatment].

BACKGROUND & OBJECTIVE: There was little report on the rule of lymph node metastasis in the cancer of mouth floor. The aim of this study was to investigate the rule of lymph node metastasis and investigate the reasonable treatment. METHODS: A total of 79 cases with squamous carcinoma of mouth floor were included into this study retrospectively. The distributive difference of clinical and pathological positive lymph node was compared. The recurrent rate of the patients who were performed with radical neck dissection and supra-half-neck dissection in clinical positive lymph node group were compared with the recurrent rate of the patients who were preformed with radical neck dissection, supra-half-neck dissection, submandibular triangle dissection, and clinical observational group. RESULTS: Clinical and pathological positive lymph node was found mainly in II region (61.8% and 40.0%, respectively), secondly in I and/or III region, and rarely in IV, V, and VI region. In clinical positive lymph node group, the recurrent rate of the patients who performed with radical cervical neck dissection was lower than supra-half-neck dissection, but without statistical significance (chi 2 = 3.403, P = 0.065). In clinical cervical negative lymph node group, the recurrent rates of the patients performed with supra-half-neck, submandibular triangle dissection, and in clinical observational group were 11.1% (1/9), 40.0% (2/5), and 23.5% (4/17), without statistical significance (chi 2 = 1.554, P = 0.46). CONCLUSION: Lymph node metastasis of cancer of floor of mouth mainly distributes in I, II, III region; The patients with negative cervical lymph node should be performed lymph node dissection in I, II, III region (supra-half-neck).

Adult↗

PubMed2002

[Influence of induction chemotherapy on long-time effect of patients with tongue squamous cell carcinoma].

BACKGROUND & OBJECTIVE: Induction chemotherapy is important in comprehensive care of patients with oral tongue squamous cell carcinoma. However, the effect of induction chemotherapy on the long-time effect was not clearly known. This study was designed to investigate the relationship between pathological negativity of primary lesion after induction chemotherapy and long-time effect in tongue squamous cell carcinoma. METHODS: The 3 year survival rate, the 5 year survival rate, survival rate with tumor free, and reasons of treatment failure of 25 patients with tongue squamous cell carcinoma which primary lesion was pathologically negative were analyzed retrospectively. RESULTS: The 3 year survival rate and the 5 year survival rate of the patients which primary lesion (91.75% and 91.66%) was pathologically negative were both higher than the patients with residual tumor (64.52% and 57.0%). The survival rate with tumor free in the former was also higher than that in the latter. The main reasons for treatment failure were local recurrence and/or regional lymph node metastasis/recurrence. CONCLUSION: Induction chemotherapy could increase the long-time survival rate of the patients with tongue squamous cell carcinoma whose primary lesion was pathologically negative.

Adult↗

PubMed2002

[Factoral analysis related to primary recurrence of laryngeal squamous cell carcinomas after treatment].

BACKGROUND & OBJECTIVE: This study was designed to investigate the factors associated with the primary recurrence in laryngeal squamous cell carcinomas after treatment. METHODS: A total of 166 cases of laryngeal squamous cell carcinomas hospitalized in Cancer Center of Sun Yat-sen University from 1990 to 1995 were reviewed retrospectively. It was considered primary recurrence that pathologically confirmed recurrence after 6 months of follow-up. The correlative factors which included age, pathological differentiation, diseased site, stage, treatment modality, surgical procedures, surgical margin, and radiotherapy with primary recurrence were investigated. RESULTS: The primary recurrence in this group after treatment was 16.3% (27/166). The primary recurrence rates in different treatment modalities of definitive radiotherapy, definitive surgery, and combined management were 50%, 8.9%, and 14.1%, respectively, which had statistical significance (P < 0.05). The primary recurrence rates in surgical and non-surgical(radiotherapy and radiochemotherapy) treatment were 11.3% and 44%, respectively, which had statistical significance(P < 0.05). The comparison of T stage in different treatment modalities showed definitive radiotherapy had earlier T stage than definitive surgery and combined therapy(P < 0.05). The primary recurrence rates in positive and negative surgical margin were 34.8% and 6.1%, respectively, which had statistical significance (P < 0.05). CONCLUSIONS: The treatment of primary site influences directly the primary relapse. Surgical treatment has better primary control than non-surgical treatment. Definitive radiotherapy has more probability of primary recurrence. The surgical clearance of the primary site influences directly the primary control.

Adult↗

PubMed2002

[Role of induction chemotherapy with bleomycin A5 in treating stage T2 tongue squamous cell carcinoma].

BACKGROUND & OBJECTIVE: Induction chemotherapy play an important role in treatment of the patients with tongue squamous cell carcinoma. This study was designed to evaluate the role of induction chemotherapy with single agent bleomycin A5 in treating stage T2 tongue squamous cell carcinoma. METHODS: The authors retrospectively analyzed the influence of surgery and induction chemotherapy with single agent bleomycin A5 plus surgery on survival rate and locoregional control among 72 patients with tongue squamous cell carcinoma. RESULTS: The 5-year survival rates were 81.46% and 57.14% respectively for the group of surgery alone and the group of induction chemotherapy plus surgery, the difference between the two groups were significant (P = 0.0229). The rates of locoregional recurrence were 22.2%, 33.3% and the medial time of recurrence was 20, 24 months respectively in the two groups. For the patients in stage II and stage III plus stage IV, there was no difference between the two groups for the 5-year survival rate (P = 0.0949; P = 0.0739). For the patients in stage III plus stage IV, the rates of locoregional recurrence were 12.5%, 35.7% and the medial time of recurrence was 12, 12.8 months, respectively, in the two groups. CONCLUSIONS: It has no significant role in treatment of the patients with stage T2 tongue squamous cell carcinoma for single agent bleomycin A5. Induction chemotherapy using single agent bleomycin A5 did not improve the 5-year survival rate for early or late primary lesions. The impact on the control rate of locoregional recurrence would be studied further for single agent bleomycin A5.

Adult↗

PubMed2002

[Effect of microwave coagulation and surgery to treat the cancer of the floor of mouth].

OBJECTIVE: The aim of this article was to clarify the value of microwave coagulation to treat the cancer of the floor of mouth by comparing the effect of microwave and surgery. METHODS: Retrospectively 87 cases of cancer of the floor of mouth who were treated by microwave coagulation and traditional surgery are analysed and the survival curve, the recurrent rate of the primary and secondary site, the oral functions, the appearance and the complications are compared. RESULTS: 1. Either in the early patients (T1 + T2) or in the advanced cases (T3 + T4), the differences of survival curve between the two groups were insignificant (P = 0.8247, P = 0.803 respectively); 2. The recurrent rate of the primary and secondary site were insignificant either (P = 0.988, P = 0.759 respectively); 3. There were more patients with a satisfied mouth function in the microwave coagulation group than that of in the surgery group, on the contrary, the cases with a worst function were few in the former(P = 0.000, P = 0.001 respectively); 4. The appearance was more satisfactory in the microwave group(chi 2 = 23.077, P = 0.000). CONCLUSIONS: To treat the cancer of the floor of mouth, microwave coagulation, as the traditional surgery, had good effects such as the same survival rate, the complication rate and local or region control rate, but the mouth function and the appearance was better than the surgery group. The microwave coagulation can be safely carried out in the practice.

Adult↗