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Biomedical subjects

Q Xie

Publications and source records attributed to Q Xie.

At least 127 records · Page 7Linked to original sources
PubMed1996

HIV infection and AIDS in China, 1985 through 1994.

OBJECTIVES: This paper analyzes data on the distribution of and risk factors for the acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection in China. METHODS: Ten years of data on persons tested for HIV infection and AIDS and the proportion who tested positive were analyzed against the background of China's population count. The Chinese- and English-language literature on HIV and AIDS from 1985 through 1995 was also reviewed. RESULTS: Overall, more males than females had HIV infection. Intravenous drug use was the primary source of transmission, followed by heterosexual contacts. Only a small number of the persons tested were homosexual, but their proportion of HIV seropositivity ranked third to that of drug users; that of general hospital patients ranked fourth. CONCLUSIONS: HIV infection and AIDS in China began as a highly regionalized and largely rural problem in Yunnan Province. However, HIV infection and AIDS have become an emerging urban problem. HIV seropositivity is low among several groups thought to have an elevated risk.

Acquired Immunodeficiency Syndrome↗
PubMed1996

Height of mandibular basal bone in dentate and edentulous subjects.

Age-related differences in the height of the mandibular basal bone were compared between young and old dentate subjects and between dentate and old edentulous subjects by means of panoramic radiographs. The distances of the mental foramen and mandibular canal from the lower border of the mandible, when measured, showed the mandibular basal bones in old dentate and in old edentulous men to be higher than those of young dentate men in the molar region (P < 0.05). The height of the basal bone below the mental foramen was smaller in old edentulous women than in young and old dentate women (P < 0.05). A slight bone deposition along the lower border of the mandible in the molar region seems to take place with increasing age. The mental foramina of edentulous women move toward the lower border of the mandible as a result of alveolar bone resorption.

Adolescent↗
PubMed1996

Testis development in the opossum Monodelphis domestica.

Testis development in the grey short-tailed opossum, Monodelphis domestica, was investigated by light and electron microscopy in 180 animals. On the day of birth, half the karyotyped males were found to have histologically differentiated testes. By day (d) 1 testicular cords were clearly distinguished in all XY gonads and the tunica albuginea was fully developed. At this stage the large and pale primordial germ cells could be differentiated from dark pre-Sertoli cells. From d 3 the testis became progressively rounded and testicular cords were surrounded by peritubular cells. Leydig cells were then distinguishable by the expected ultrastructural features of steroidogenically active cells, showing abundant vesicles of SER, extensive mitochondria with tubular cristae and numerous lipid inclusions. Subsequently these cells formed clusters and were surrounded by envelope cells until wk 12. Testes were located in the abdomen, attached to the large mesonephroi, until d 24 after birth when they began their descent to the scrotal sac. From 7 wk the interstitial tissue became less cellular. At the prepubertal stage (12 wk), the seminiferous tubules lacked lumina. Leydig cell cytoplasm was electron-dense with increased amounts of SER forming parallel profiles. By 4 mo (pubertal stage), seminiferous tubules were patent and various spermatogenic stages, including spermatozoa, were seen for the first time. Leydig cells then greatly outnumbered other interstitial tissue cells and were closely-packed around blood vessels but no longer clustered by envelope cells; their SER was very highly organised into masses of parallel arrays and lipid inclusions were reduced. In the adult (1 y) Leydig cells reached their greatest size; their morphological features resembled those seen at 4 mo except that lipid inclusions were sparse. In ageing Leydig cells (2-3 y), large amounts of SER were present but disorganised.

Animals↗
PubMed1995

Identification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: requirement for efficient viral DNA replication.

Geminiviruses are plant DNA viruses with small genomes whose replication, except for the viral replication protein (Rep), depends on host proteins and, in this respect, are analogous to animal DNA tumor viruses, e.g. SV40. The mechanism by which these animal viruses create a cellular environment permissive for viral DNA replication involves the binding of a virally encoded oncoprotein, through its LXCXE motif, to the retinoblastoma protein (Rb). We have identified such a LXCXE motif in the Rep protein of wheat dwarf geminivirus (WDV) and we show its functional importance during viral DNA replication. Using a yeast two-hybrid system we have demonstrated that WDV Rep forms stable complexes with p130Rbr2, a member of the Rb family of proteins, and single amino acid changes within the LXCXE motif abolish the ability of WDV Rep to bind to p130Rbr2. The LXCXE motif is conserved in other members of the same geminivirus subgroup. The presence of an intact Rb binding motif is required for efficient WDV DNA replication in cultured wheat cells, strongly suggesting that one of the functions of WDV Rep may be the linking between viral and cellular DNA replication cycles. Our results point to the existence of a Rb-like protein(s) in plant cells playing regulatory roles during the cell cycle.

Amino Acid Sequence↗
PubMed1995

Changes in the position of the mental foramen as a result of alveolar atrophy.

The location of the mental foramen has often been claimed to be unaffected by alveolar atrophy. In the present study, the distances of the mental foramen and the mandibular canal from the lower cortex of the mandible were compared in a radiographed series of 40 edentulous elderly women with advanced alveolar atrophy and 40 elderly women who had 10 or more lower teeth left. The mental foramen was situated on average 3.8 mm lower in dentulous jaws than in dentulous jaws (P < 0.0001). The mandibular canal was also situated lower in edentulous jaws, but the difference was not statistically significant. The results confirm the finding that the mental foramen seems to descend as a result of alveolar atrophy.

Aged↗
PubMed1995

[Missed diagnosis in prostate incidental carcinoma].

522 cases of benign prostate hyperplasia from 1980 to 1994 were reviewed. Prostate incidental carcinoma (PIC) was identified in 26 cases (4.98%). In order to study the pathomorphological features and to study the causes for missed diagnosis of this entity, the authors observed and analysed the numbers of carcinomatous foci their distribution, classification, staging and differentiation, morphological features and prostate specific antigen (PSA) markers. It was found that 23 cases exhibited a pathological structure of uniform pattern and 3 cases with pluriform pattern. Adenocarcinoma was most common. 17 cases were A1 stage and 9 cases were A2 stage. Isolated multiple foci of invasion and alterations of architecture are important pathological features of these cases. Missed diagnosis of prostate cancer is related to the small amount of biopsy tissue, contrast between benign and malignant prostate epithelial tissue not distinct, scarce nuclear anaplasia, careless microscopic observation, or observer lacks the ability to differentiate between pathologic types and pluriform patterns. Different PSA reactions may be related to tumor differentiation and classification.

Adenocarcinoma↗
PubMed1994

The high-output nitric oxide pathway: role and regulation.

Nitric oxide synthase (NOS) catalyzes the production of nitric oxide (NO), a short-lived radical gas with physiological or pathophysiological roles in nearly every organ system. The inducible NO synthase (iNOS) is a high-output isoform compared to the two constitutive NOSs. The iNOS from murine macrophages tightly binds calmodulin as a subunit, and its activity is not dependent on exogenous calmodulin or elevated calcium. This iNOS is induced at the transcriptional level by bacterial lipopolysaccharide (LPS) and interferon-gamma. The promoter region of the murine iNOS gene contains at least 24 oligonucleotide motifs corresponding to elements involved in the binding of transcription factors in the promoters of other cytokine-inducible genes. Nuclear factor NF-kappa B/c-rel, interacting with cycloheximide-sensitive protein(s) and binding to the NF-kappa Bd site in the iNOS promoter, controls the induction of iNOS by LPS. However, iNOS is also regulated posttranscriptionally. Complex regulation of iNOS at multiple levels may reflect the dual role of iNOS in host defense and autotoxicity.

Amino Acid Oxidoreductases↗
PubMed1994

Serum and tissue levels of estradiol during estrogen-induced renal tumorigenesis in the Syrian hamster.

The estrogen-induced renal tumor in the hamster has emerged as a major animal model in hormonal carcinogenesis. However, a fundamental aspect of this experimental model has as yet not been investigated. In the present study, comparisons between the serum and tissue 17 beta-estradiol (E2) levels in cyclic female hamsters and corresponding hormone levels in E2-treated castrated male hamsters have been made. Data is provided concerning the concentration of estrogenic hormones in the serum and target tissue typically required to elicit renal tumorigenesis in this species. Serum E2 levels in the cyclic female hamster average 79 pg/ml on days 1-2 and 311 pg/ml on days 3-4, attaining a maximum of 358 pg/ml on day 4 of the cycle. Elevation in uterine, renal and hepatic E2 tissue levels during days 3-4 of the cycle reflect increases in serum E2 levels which were 3.0-, 2.0-, and 2.6-fold higher when compared to day 1 of the cycle in these tissues. As expected, serum E2 levels of untreated castrated male hamsters did not appreciably vary over a 6 month period of aging and averaged about 32 pg/ml. Under conditions which produced essentially 100% renal tumor incidence, a rapid rise in serum E2 levels, averaging 71.0-fold higher than untreated castrated levels, was seen. A steady state serum E2 level of 2400 to 2700 pg/ml was maintained from 45-180 days of continuous estrogen treatment. Compared to kidneys of untreated hamsters, renal E2 levels in E2-treated hamsters rose only on average 5.4-fold between 15-180 days of hormone exposure. Serum levels of E2-treated hamsters were 5.7- to 8.0-fold higher than those observed in cyclic female hamsters on days 3 and 4. However, at these higher E2-treated serum levels there was no apparent effect either on weight loss or mortality of the animals.

Animals↗
PubMed1994

Radiographic findings in the jaws of clinically edentulous old people living at home in Helsinki, Finland.

In the present survey the radiographic findings in the jaws of 124 clinically edentulous old people living at home in Helsinki, Finland, were studied, using panoramic radiography supplemented by intraoral radiographs. Only 9% of the subjects had root remains. Impacted teeth were found in 4%, radiolucent lesions in 3%, and radiopaque findings in 13%. Deviations from normal condylar structure were found in 17% and mucosal thickenings in the maxillary sinuses in 7%. The mental foramen was situated at the top of the residual ridge in 42% of the subjects. Topically situated mental foramen and condylar changes were commoner in women. The radiographic oral health status of the population studied was good.

Aged↗
PubMed1994

Sensibility threshold in patients with masticatory muscle pain.

Sensibility and pain thresholds were measured in 27 patients with myofascial pain and craniomandibular disorders and in 19 controls. A monopolar electric stimulator with increasing direct current values was used to record pain and sensibility thresholds in the lower incisors. Patients with myofascial pain had a tendency towards lower sensibility and lower pain thresholds than the controls, although the differences were not statistically significant.

Adult↗
PubMed1994

[CT morphology of hepatocellular carcinoma lesions].

The preoperative CT appearances of hepatocellular carcinoma (HCC) lesions in 232 cases were analyzed. According to the CT features in shape, outline and boundary of the tumors, the HCC was divided into 3 Types: Type I--roundish expansive growth type (REG TYPE), Type II--irregular expansive growth type (IREG TYPE), and type III--irregular infiltration growth type (IIG TYPE). Comparing different CT types with findings at laparotomy or pathological specimens, it showed that the intrahepatic tumor dissemination rates of type I, II and III were 18.6%, 37.7%, and 47.8%, respectively. The lymph node metastasis rates were 0, 7.7% and 23.1%, respectively. The portal vein tumor thrombus formation rates were 2.3%, 20.8% and 46.4%, respectively. The proportion of encapsulation (67.4%, 27.3% and 5.28%, respectively) apparently decreased from type I to type III in turn. The differences were statistically significant. From type I to III the resection rate of large sized tumor decreased, and the prognosis was from bad to worse. Survival analysis (Cox's mode) showed significant differences from type I to type III. Therefore, CT classification may be used to evaluate the gross biological behavior of HCC lesions and may be of pathological and clinical relevance.

Adolescent↗
PubMed1991

[Clinical value of the Chengdu classification of non-Hodgkin's lymphomas].

Two hundred forty-nine cases of non-Hodgkin's lymphomas (NHL) were reviewed by using the working classification of NHL (Chengdu, 1985). The results showed that the patients of 249 cases of NHL ranging in age from 5 to 76 years, with the mean age of 42 of the types were separated into three major prognostic groupings as follows: 1. low (41 of 249 cases, small lymphocytic 27 cases, lymphoplasmacytoid 2 cases, follicular cleaved 7 cases, follicular cleaved and noncleaved 5 cases); 2. intermediate (58 of 249 cases, diffuse cleaved 28 cases, diffuse cleaved and noncleaved 27 cases, follicular noncleaved 3 cases); and 3. high grade malignancy (150 of 249 cases, diffuse noncleaved 49 cases, lymphoblastic 41 cases, immunoblastic 13 cases, polymorphic 39 cases, clear cell 2 cases, histiocytic 6 cases). Each group was significantly different from the others (P less than 0.05). The prognosis of patients with angioimmunoblastic lymphadenopathy like T-cell lymphoma (9 of 249 cases) was not more significant (P greater than 0.05) than that of patients with other polymorphic lymphoma (30 of 249 cases). The results showed this Chengdu classification of NHL is good for practice and usage in clinical evaluation and routine surgical pathology.

Adolescent↗