Search PubMed⌕ Search

Biomedical subjects

P Wright

Publications and source records attributed to P Wright.

At least 289 records · Page 16Linked to original sources
PubMed1976

Pathology of practolol-induced ocular toxicity.

The ocular side-effects of prolonged practolol administration concern the cornea and conjunctiva and are related to deficient tear secretion and the formation of an autoantibody which has an affinity for the intercellular zones of squanmous epithelium. Histopathological study of six cases, including a review of the necropsy findings in two, showed destruction of lacrimal gland tissue, epidermalization of the conjunctival epithelium, with epitheliolysis and stromal ulceration of the cornea leading to perforation in two patients. Immunoperoxidase studies showed fixation of specific antibody in the corneal and conjunctival epithelium but, in the one case in which the tissue could be adequately studied, complement fixation could not be demonstrated. Possibly, therefore, the immune response in patients with practolol-induced ocular damage is secondary to the epithelial disturbance rather than its cause.

Aged↗
PubMed1975

Quality and quantity of survival in acute myeloid leukaemia.

The quality of life in leukaemia is as important as its quantity. In fifty-one patients the quality and quantity of life were improved by less aggressive treatment than is usual. By not trying to induce complete remission at all costs, the mobidity and early mortality were reduced and at least an equivalence in survival was obtained.

Acute Disease↗
PubMed1975

Untoward effects associated with practolol administration: oculomucocutaneous syndrome.

Keratoconjunctivitis sicca, conjunctival scarring, fibrosis, metaplasia, and shrinkage developed in 27 patients as an adverse reaction to practolol. Rashes, nasal and mucosal ulceration, fibrous or plastic peritonitis, pleurisy, cochlear damage, and secretory otitis media also occurred in some cases. Three patients suffered profound visual loss though most retained good vision. Symptoms and signs improved on withdrawal of the drug, but reduction of tear secretion persisted in most patients.

Adult↗
PubMed1975

'Just fill in this form' - a review for designers.

This paper reviews the behavioural research, particularly on language and comprehension, which can be related to the design of forms. Such research gives rise to a number of simple rules which can be implemented by forms' designers. These rules concern the structure, content and organisation of sentences and questions. The paper illustrates how these rules can be applied to forms currently in use. Research findings which point to exceptions to the general rules are discussed in an appendix. The paper recognises that we do not yet have enough information to design perfect forms, but that there is enough for many forms to be improved and potential pitfalls avoided.

Journal Article↗
PubMed1975

Filamentary keratitis.

Evidence is offered to support a hypothesis that filaments are composed of mucus with epithelial squames, lipid, and foreign matter taken up secondarily. The condition results when mucus excess is present with receptor sites on the cornea. Treatment should be directed at the receptor sites, the mucus excess, or the underlying conditions responsible for the two components.

Acetylcysteine↗
PubMed1975

The dry eye.

Explore the source record for details and available documents.

Acetylcysteine↗
PubMed1975

Colon carcinogenesis with azoxymethane and dimethylhydrazine in germ-free rats.

The effect of intestinal microflora on the sensitivity of the colon to the carcinogenic effect of azoxymethane and a large dose of 1,2-dimethylhydrazine was studied using germ-free and conventional female Fischer rats. Injection s. c. of 1,2-dimethylhydrazine-induced tumors of the ear duct, kidney, and small intestine of conventional rats but none in germ-free animals. Only 20% germ-free rats showed 1,2-dimethylhydrazine-induced colonic tumors, whereas 93% of conventional rats developed multiple colonic tumors. Intrarectal instillation of azoxymethane appreciably increased the multiplicity of colonic tumors in germ-free rats and in gnotobiotic rats contaminated with Clostridium perfringens, as compared to conventional controls. None of the germ-free rats showed ear duct tumors. The incidence of kidney tumors was lower in germ-free rats than in other groups. It is concluded than the intestinal microbial populations alter the effect of carcinogens in the large intestine.

Adenocarcinoma↗