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Biomedical subjects

P Vestergaard

Publications and source records attributed to P Vestergaard.

At least 181 records · Page 10Linked to original sources
PubMed1978

The hydrolysis of conjugated neutral steroids in urine.

Complete hydrolysis of known conjugates of neutral steroids in urine requires a combination of solvolysis and enzymatic hydrolysis. Procedures are established for optimal yield in the enzymatic part of the hydrolysis using different preparations of beta-glucuronidase. The effect of temperature and the use of conjugate extraction in the hydrolytic procedure is explored. It is stressed that relatively high concentrations of enzyme are necessary to insure full hydrolysis of a few conjugates that are particularly difficult to split by enzymatic hydrolysis.

Animals↗
PubMed1978

Factors affecting the excretion of common neutral steroids in urine.

After a brief summary of the biosynthesis, production rates, metabolism and elimination of the pertinent adrenocortical and gonadal precursors for the common urinary neutral steroids, a survey is presented of the general, disease related and hormonal factors that can affect the excretion of neutral steroids in urine.

Adrenal Cortex Hormones↗
PubMed1977

Relationship between steroid excretion patterns and breast cancer incidence in Israeli women of various origins.

A nationwide study of the steroid excretion patterns in postmenopausal Israeli migrant women demonstrated differences between high- and low-risk groups for breast cancer in the following variables: age at first parturition, number of pregnancies, number of live births, height, and weight. The direction of the differnces was in line with those observed for breast cancer patients. The groups also differed in the exretion of estriol, 17-ketosteroids, and allotetrahydrocortisol. Multiple regression analysis revealed that the exretion of estriol was significantly lower in population groups in whom breast cancer incidence was high. Possibly this trend--which has also been observed in adolescent and premenopausal women--reflected environmental influences on peripheral estrogen metabolism.

17-Ketosteroids↗
PubMed1977

Total and subtotal colonoscopy with short instrument and without fluoroscopy.

The technique and results of 111 consecutive colonoscopies with a short colonoscope without the use of X-ray screening are reviewed. The caecum could be reached in 44 percent of the cases. No complications occurred. The great clinical value of the procedure is shown by the following findings:X-ray-negative lesions--including 2 cases of carcinoma--were found in 35 percent of the cases, radiologically demonstrated lesions could be defined more precisely in 18 percent, and the presence of colonic lesions could be ruled out in 11 percent in spite of equivocal X-ray findings. It is concluded that many more centres ought to take up the procedure, which offers the prospect of significantly reducing suffering and death from colonic disease.

Adult↗
PubMed1977

Lithium treatment of Huntington's chorea. A placebo-controlled clinical trial.

The therapeutic effect of lithium in Huntington's chorea was tested in six patients through a double-blind cross-over comparison of lithium and placebo, each administered for 6 weeks. Four of the patients received neuroleptic drugs at the same time. Lithium and placebo periods did not differ as regards motor skills, hyperkinesias, or total ward situation, all rated quantitatively with the use of scales. Lithium does not seem to be of therapeutic value in Huntington's chorea.

Adult↗
PubMed1975

Computerized multicuvette system for single substance and group analysis and for the chromatographic isolation and quantitation of compounds in complex mixtures.

A new computer-interfaced system of general applicability in the clinical laboratory has been built. The system is constructed around a new type multicuvette. Quantitation is currently by spectrophotometry and is on-line, with use of a mini-computer with output going to an electrostatic printer/plotter. The system can be used for single-substance batch analyses, for group analyses, and for the estimation of profiles of compounds after preliminary high-resolution liquid chromatography tailored to interface with the multicuvette.

17-Ketosteroids↗