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Biomedical subjects

P Talwar

Publications and source records attributed to P Talwar.

54 records · Page 3Linked to original sources
PubMed1978

Visceral leishmaniasis masquerading as a nasopharyngeal tumour. Report of a case.

A 55-year-old male, a resident of a village in the foothills of the Himalayas in the north-western region of India, presented with a huge nasopharyngeal tumour but was subsequently found to be infected with Leishmania donovani, involving the nasopharyngeal tissue and the draining lymph nodes as well as a visceral infection.

Diagnosis, Differential↗
PubMedDate not supplied

Surveillance of nosocomial fungal infections in a burn care unit.

A survey was conducted to trace the source of nosocomial fungal infections in the burn care unit of Nehru Hospital, Chandigarh, India, by collection of samples from wounds of 25 severely burnt patients and their surroundings. The environmental sampling revealed predominant fungal contamination by dematiceous hyphomycetes, aspergilli, Penicillium, Fusarium and yeasts (Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis), whereas the colonising or invading fungi from the patients were Aspergillus flavus and yeasts of the genus Candida (C. albicans, C. tropicalis, C. krusei, C. parapsilosis, Torulopsis glabrata). This study thus corroborates the more pathogenic potential of some of the environmental fungal isolates located in the vicinity of the immunocompromised patients and stresses the need for decontamination of the environment of the burn care unit.

Air Microbiology↗
PubMedDate not supplied

Comparative bioavailability and in-vitro antimicrobial activity of two different brands of rifampicin.

A comparative bioavailability study was undertaken between a new formulation of rifampicin 'Famcin' and a standard formulation of rifampicin 'R-cin' in eight healthy male volunteers at two dose levels: 300 mg and 450 mg given orally under both single dose and steady state conditions. Plasma rifampicin was assayed spectrophotometrically. The study documented comparable rate and extent of bioavailability. (Cmax, Tmax and AUC0-infinity) and elimination half-lives (t1/2) of the two brands of rifampicin when compared at similar dose levels. The study establishes the bioequivalence of Famcin to that of the standard brand R-cin. Further, a comparative in vitro microbiological sensitivity of the two brands of rifampicin was undertaken against several strains of two test micro-organism viz. Staphylococcus aureus and Mycobacterium tuberculosis. For both the micro-organisms the minimal inhibitory concentration of Famcin was lower than that of R-cin, suggesting a somewhat greater potency of Famcin in suppressing the growth of test micro-organisms.

Administration, Oral↗
PubMedDate not supplied

Incidence of cryptococcosis in and around Chandigarh, India, during the period 1982-91.

The incidence of cryptococcosis was evaluated in and around Chandigarh, India over a period of 10 years (1982-91). Different species of Cryptococcus were isolated from 38 patients. Cryptococcus neoformans was the predominant isolate (26 = 68%) followed by Cr. albidus (2), Cr. laurentii (1) and not precisely identified Cryptococcus species (9 = 24%). Serotyping of the 18 isolates of Cr. neoformans revealed that 13 (72%) were serotype A, two (11%) were serotype AD and three (17%) were serotype B (Cr. neoformans var. gattii). Cryptococcus species were found to produce infection in 24 patients and were possibly transient colonizers in another 14 patients. In addition, in 11 patients no Cryptococcus species was isolated from any site but the latex agglutination test for antigen (Crypto-LA) was positive in serum and/or cerebrospinal fluid. Response to various antifungal drugs was also studied in these patients.

Amphotericin B↗