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Biomedical subjects

P Talwar

Publications and source records attributed to P Talwar.

At least 37 records · Page 2Linked to original sources

Fungal infections of ear with special reference to chronic suppurative otitis media.

Fungus were found to take important role in ear infections of the 344 patients (CSOM 286, Otomycosis 44, Otitis externa 14), significant fungal infections (with positive smear and culture) were detected on 49%, 79.5%, 66.6% patients respectively. 84.8% patients were detected both by smear and culture, 14.1% patients by culture and 0.1% patients in smear preparation only. In CSOM patients, age predominated in 20-27 yrs group, sex in male below 30 yrs, and Aspergillus flavus, A. niger, Penicillium, A. fumigatus in mycelial fungus, Candida albicans, C. parapsillosis in yeast. But in 18 post antibiotic fungus infected patients Penicillium and A. niger were the important isolates. In otomycosis and otitis externa patients A. niger took the main role.

Adult↗

Standardization and demonstration of antibody-coated Candida in urine by direct immunofluorescence test.

Acetone, carbontetrachloride, ethyl alcohol, mixture of ethyl alcohol and acetone, and heat were assessed for fixative property for direct immunofluorescent (IF) staining of antibody-coated Candida cells. The results indicated that ethyl alcohol was the most suitable fixative for the test. Antisera containing 16 units of Candida albicans type A agglutinin were found essential to get optimal detectable fluorescence of antibody-coated yeast cells. IF test showed cross reactivity between the yeasts of C. albicans and C. tropicalis. However, there was no cross reactivity with the conidia of A. flavus. The direct IF test could demonstrate antibody-coated yeast cells and pseudomycelia in deposits of urine in the direct smear. It correlated well with microscopy and culture studies. At times, it could demonstrate the antibody-coated yeasts earlier than routine significant culture. It could also differentiate the significant from non-significant fungal isolates from urine.

Agglutination Tests↗

Prevalence of bacteria and fungi in athlete's foot of varying severity and response to topical antibacterial and antifungal therapies.

Ninety-six patients with clinical evidence of interdigital lesions classified as mild, moderate and severe athlete's foot were investigated for bacterial and fungal populations in the interspaces. Gram-negative bacteria, which were not found in the toe spaces of 50 normal controls, were grown in increasing numbers and with increasing frequency as the symptoms progressed from mild to severe. Gram-positive bacteria were also isolated regularly and in increasing numbers commensurate with the severity of the disease. Similarly the isolation rates of dermatophytes and Candida species were higher in patients with moderate and severe disease compared to those with mild disease. Clinical and culture responses to topical applications with framycetin, tolnaftate, miconazole and clotrimazole were also studied. In some patients the prevalence of pathogenic fungi increased as bacterial numbers decreased. The pure antibacterial framycetin brought symptomatic relief, as did the purely anti-dermatophyte substance tolnaftate, but best results were seen with two azole compounds having mixed antibacterial and antifungal properties.

Adult↗

Primary mycotic infection of paranasal sinuses.

Eight cases of primary mycotic infection of paranasal sinuses with Aspergillus and Candida species encountered during July, 1979 to December 1981 are being presented. Their clinical, mycological and serological responses have been discussed. Aspergillus flavus was isolated from all the seven cases with aspergillosis and Candida albicans, along with C. tropicalis, was isolated from one case.

Adult↗

De-epithelialised "turn over" axial-pattern flaps in the lower extremity.

Leonard (1981) has reported the successful use of a de-epithelialised "turn over" deltopectoral flap for a chest wall defect. This paper presents the application of the principle of a de-epithelialised " turn over" type of flap to the fasciocutaneous flap described by Pontén (1981) and the dorsalis pedis flap described by O'Brien and Shanmugam (1973) and McCraw and Furlow (1975) for defects of skin and subcutaneous tissue in the lower extremity. The reason for their choice and the alternatives are briefly discussed and some general comments are added on the use of de-epithelialised "turn over" flaps.

Humans↗

Serology of Aspergillus granuloma.

A total of 21 cases of granuloma caused by Aspergillus species were encountered during the period 1972-79. The organs involved were nasal and paranasal sinuses, brain, orbit, subcutaneous tissue of check, lungs and endocardial valve in the decreasing order of their frequency. Aspergillus flavus was the main etiological agent. Immunodiffusion tests with various Aspergillus species as antigen showed a positively of 17 out of 18 (94.4 per cent) cases. The role of precipitins in diagnosis and prognosis of the disease has been discussed.

Adolescent↗

Penile tinea.

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Adolescent↗

Frequency and significance of fungal isolations from conjunctival sac and their role in ocular infections.

Five hundred conjunctival swabs, from 150 males and 100 females with no history of ocular infections, were collected and cultured for the isolations of fungi. Eighty (16%) of the total specimens yielded positive fungal isolations. The isolation rate was more from the males than the females subjects. Mycelial fungi were predominant than the yeast organisms. Aspergillus species were the commonest isolates with A. flavus taking the lead in the isolations being positive 16 of the total 24 Aspergillus species isolated. A variable rate of fungal isolations was observed in different months of the year. The percentage of the isolations increases after the local use of Efcorlin-N. Nineteen of the 20 eyes studied did not yield the same fungal species in the repeated samples.

Adolescent↗

Pulmonary nocardiosis. A report of eight cases.

Eight cases of pulmonary nocardiosis are reported. Nocardia species were isolated and identified in five cases while the aetiological agents could not be isolated in three cases. Four isolates were identified as N. asteroides and one as N. brasilienisis. Candida infection was associated in three cases. Six cases were found in the 40-60 year age group while two patients were children.

Adult↗

Mycetomas in North India.

Of 60 clinically suspected cases of mycetoma, 20 were confirmed by cultural and histopathological methods. The feet were found to be affected in 70% of the cases. The age group most affected by the disease was 20-40 years. Men were involved in 18 while females were affected in 2 cases only. Actinomycetomas (70%) were found more often than eumycetomas (30%). Nocardia species were identified in 35% of cases and Madurella mycetomi in 25%. There were four cases (20%) where the etiological agents could not be identified; these were suspected to be due to Actinomadura madurae. A. pelletieri, A. madurae, an unidentified anaerobic actinomyces, and Phialophora jeanselmei, were identified in one case each.

Actinomycetales↗