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Biomedical subjects

P Svendsen

Publications and source records attributed to P Svendsen.

138 records · Page 8Linked to original sources
PubMedDate not supplied

The effect on pregnancy of treatment with antibodies against pregnancy-associated murine protein I (PAMP-I) in inbred and outbred mice.

Intravenous injection of small amounts of monospecific rabbit IgG against pregnancy-associated murine protein I (PAMP-I) induced abortion in mice where there was a histocompatibility difference between mother and fetuses. No abortion could be induced in inbred mice by a similar treatment. The maternal serum level was found to be higher in inbred than in outbred mice. The abortive dose of antibodies did not influence the serum levels of PAMP-I. Histological examination of uterine, placental and liver tissue showed only morphological changes in the placental tissue of mice which aborted due to the treatment with anti-PAMP-I antibodies.

Abortion, Spontaneous↗
PubMedDate not supplied

Calibration of a reflectance pulse oximeter in fetal lambs for arterial oxygen saturations below 70%.

OBJECTIVE: To calibrate a reflectance pulse oximeter developed at the Division of Perinatal Physiology, University Hospital of Zurich, for monitoring of oxygen saturations below 70%. METHODS: Oxygen saturation measured noninvasively with the reflectance pulse oximeter in fetal sheep was compared with oxygen saturation of arterial blood samples measured by a conventional two-wavelength oximeter. Oxygen saturation was varied by stepwise reduction of the inspired oxygen concentration of the ewe. RESULTS: A total of 58 data pairs was obtained from five fetuses, with a range of 10.9-73.5% for the reference method and 6.8-69.2% for the pulse oximetry oxygen saturation values. There was good correlation between the results obtained by the two methods (r2 = .89, P < .0001), with a 95% confidence interval of +/- 12.5%. The pulse oximeter showed a precision of 6.2% oxygen saturation. CONCLUSION: The Zurich reflectance pulse oximeter offers valid measurements of oxygen saturation levels down to 10% oxygen saturation, and is therefore suitable for monitoring the fetus during delivery.

Animals↗
PubMedDate not supplied

An animal model for the study of the function of pregnancy-specific beta 1-glycoprotein and pregnancy zone protein: a review.

Two pregnancy-associated murine proteins, PAMP-1 and PAMP-2, have been found to be immunologically cross-reacting analogues to the human proteins pregnancy zone protein (PZP) and pregnancy-specific beta 1-glycoprotein (SP-1), respectively. In this study, the physiochemical and biological properties of the proteins are compared and the effect on pregnancy of administration of monospecific antibodies against the proteins is reported.

Abortion, Induced↗
PubMedDate not supplied

Eustachian tube function and retraction of the tympanic membrane.

The medial displacement of the tympanic membrane or the retracted tympanic membrane is a common clinical finding. Also, retractions are looked upon as the precursor of middle ear cholesteatoma. In current otologic literature there seems to be some dispute whether the retractions of the tympanic membrane are caused by negative intratympanic air pressure or by shrinkage of middle ear adhesions pulling the tympanic membrane or part of it medially. In this study only ears with posterior/superior retractions of the tympanic membrane were investigated. Tympanometry revealed that only 33% of the ears did have middle ear pressure within +/- 100 mm H2O. After insertion of a polyethylene tube through the tympanic membrane, the eustachian tube function was tested using the air pressure equalization technique. None of the ears could change the negative air pressure upon swallowing. Planometric measurements on the x-ray of the mastoid air cell system of the present material deviate from those of a normal material, indicating a significantly smaller air volume in the present material. It may be concluded that dysfunction of the eustachian tube and a small air volume of the mastoid are characteristic features of an ear with posterior/superior retraction of the tympanic membrane.

Adult↗
PubMedDate not supplied

Venous malformations in the face and neck. Radiologic diagnosis and treatment with absolute ethanol.

Venous malformations in the face and neck have a characteristic clinical picture. They consist of a cluster of venous cavities with a very slow blood flow and are normally not demonstrated at conventional external carotid angiography. Previous methods of treatment have been of limited value but recently good results have been reported with instillation of fibrosing agents as Ethibloc and ethanol. Five patients with facial venous malformations were referred for therapy. External carotid angiography was performed and was almost normal in all patients. Superselective catheterization demonstrated the malformation clearly in 2 patients only. Direct puncture phlebography confirmed the diagnosis by demonstrating the venous cavities in all the patients. This procedure was concluded by instillation of absolute ethanol into the cavities. There was a marked reduction in size of the malformation but it was not permanently completely occluded. The treatment was repeated in 4 patients with further reduction of the size, but small remnants are still left. Serious complications with extensive soft tissue necrosis occurred in one patient probably as a result of extravasation of ethanol. The necrosis later healed well after surgical treatment. Instillation of ethanol under radiologic control seems to be a promising way of treatment of venous malformations.

Adult↗
PubMedDate not supplied

Juvenile nasopharyngeal angiofibroma. A report of eighteen cases.

Juvenile nasopharyngeal angiofibroma is a disease afflicting mainly adolescent males. The lesion is benign but characterized by local aggressive growth. In advanced cases the tumour may extend intracranially. In this study 18 cases of juvenile nasopharyngeal angiofibroma were investigated. Tumour extension was assessed with the use of angiograms and CT and the individual cases staged in four different categories on the basis of tumour extension. Two cases were staged as I (tumour confined to the nasopharynx), 7 cases as II (tumour extending into nasal cavity and/or sphenoid sinus), 8 as III (tumour extending into one or more of the following: antrum, ethmoid sinus, pterygomaxillary and infratemporal fossae, orbit and/or cheek) and one as IV (tumour extending into the cranial cavity). Preoperative arterial embolization was performed in 8 cases. All patients underwent surgery; none received irradiation. The follow-up period was 6 yrs 4 mo (6 months-17 years). In one case of intracranial extension, tumour recurrence occurred. It is concluded that with the aid of CT and arteriograms to evaluate the extension of the tumour and preoperative embolization, this lesion can be cured in the vast majority of cases, with surgery as the method of choice.

Adolescent↗
PubMedDate not supplied

Carotid endarterectomy. A review of 104 operations.

A follow-up of 104 carotid endarterectomies in 90 patients is presented. The operations were performed under general anaesthesia with controlled positive pressure ventilation and with peroperative EEG-registration. The patients have been divided into four groups: Group 1: Patients with no neurological symptoms. Group 2: Patients with transitory ischemic attacks (TIA). Group 3: Patients with neurological deficits. Group 4: Patients with cerebro-lesional symptoms. The specific neurological symptoms as well as the early surgical results and the results of the follow-up are presented. An evaluation of different kinds of X-ray examinations and of EEG-registration has been performed.

Adult↗
PubMedDate not supplied

Treatment of direct carotid-cavernous fistulas with detachable balloons.

Experience with transarterial treatment of 14 direct carotid-cavernous fistulas using the Debrun technique with detachable balloons manually tied to the catheter is reported. Ten of the fistulas were occluded by balloons with concomitant occlusion of the internal carotid in one case. Another fistula closed spontaneously in connection with the embolization procedure. Three fistulas were treated with surgical trapping after recurrence. The transvenous approach was attempted in three cases but failed. Four complications occurred, two with clinical consequences as the patients developed neurologic deficits. Except in four cases with persistent or slowly regressing orbital palsies all signs and symptoms of the fistula disappeared after successful occlusion. The use of detachable balloons for selective occlusion is in experienced hands a rather safe and simple method with good results. Large fistulas offer most problems, and to avoid progression in fistula size the treatment should be undertaken as soon as possible after diagnosis.

Adolescent↗