Search PubMed⌕ Search

Biomedical subjects

P Sole

Publications and source records attributed to P Sole.

At least 19 recordsLinked to original sources
PubMed1992

Recent developments in medical therapy of POAG with beta blocking agents.

Since 1987, an entirely computerized open study has been developed in Pr Sole's Ophthalmology Department: the CLERTORE project (Clermont-Tonus-Research). It is a data bank including all the ophthalmic data of hypertensive patients, whether treated or untreated. Every six months, the patients included in the CLERTORE project undergo a clinical ophthalmic examination as well as an automated visual field examination (OCTOPUS 500), an examination of the optic disc (ONHA) and fluorophotometry (FLUOROTRON MASTER). To date, 92 patients have been included in the project. One hundred and eighty-three eyes are examined every six months with a maximal follow-up of 42 months. Because of the numerous criteria of the data base, it is too early to give any statistical results. With a close look at the evolution of the examinations of some of our cases, this preliminary work however allows us to make the three following remarks: In the hypertensive patients, a modification of the papillary pallor is observed without any change in the visual field, C/D ratio and fluorophotometry. The pallor is clearly modified when adrenaline eye drops are given to glaucomatous patients. There is a break of the iridic blood barrier in some hypertensive patients, whether treated or untreated.

Adrenergic beta-Antagonists↗
PubMed1991

[Double-blind study of the comparative action of indomethacin 0.1% and placebo on the breakdown of the blood-retinal barrier].

The oral fluorophotometric exploration is able to simultaneously quantify the permeability of the blood aqueous (KIN, KOUT) and blood-retinal (PVPR) barriers. It is possible to detect the breakdown of the blood aqueous barrier 3 days after cataract surgery with this fluorophotometric method. Ocular inflammation is responsible for this leakage and non steroidal anti-inflammatory drugs prevent this breakdown. In this paper, we studied the effect of 0.1% indomethacin treatment to patients before and after cataract surgery. This double-blind study was performed in 34 patients: 18 patients in the indomethacin group and 16 patients in the placebo group. We showed that the apparent transfer coefficient of fluorescein in the anterior chamber (KIN) was statistically lower in the indomethacin group (0.0220 +/- 0.0179 hr-1) than in the placebo group (0.0371 +/- 0.0187 hr-1) on the 3rd postoperative day (p = 0.027).

Adult↗
PubMed1988

[Papillometry].

Explore the source record for details and available documents.

Glaucoma↗
PubMed1987

[Fluorophotometry by instillation. I. Flow of the aqueous humor and corneal endothelial permeability].

Among various fluorophotometric methods performed on the anterior segment, topical administration of fluorescein was developed. This local administration allows to measure the aqueous humor flow and the permeability of the corneal endothelial. The examinations are performed on a computerized fluorophotometer: the Fluorotron Master. This fluorophotometer has been designed to accurately measure fluorescein's concentrations into the eye and especially in aqueous humor and cornea. Anterior chamber adapter magnifies the scan for detailed work in the anterior chamber and lens. The Fluorotron is supplied with a cuvette holder and a cuvette which is adapted to the optical head for measuring the concentration of fluorescein in blood plasma or in buffered aqueous samples. A good linearity was obtained between the meter readings and the concentrations of fluorescein in phosphate buffer with pH 7.4, within the range between 1 ng and 1000 ng. Based upon the mathematical analysis of Yablonski the method by fluorescein instillation is simple and safe and gives the loss coefficient, ko, of the dye from the anterior chamber, the aqueous humor flow, F, and the endothelial transfer coefficient kc.ca. Calculations were carried out on twenty one normal eyes yielding average values for F 2.97 +/- 0.93 microliter.min-1 (Mean +/- S.D.) and for kc.ca 4.02 +/- 0.40. 10(-1) min-1. These values are comparable to those of other authors.

Aqueous Humor↗
PubMed1987

[Fluorophotometry by instillation. II. Effect of beta-blocker eyedrops in the normal subject].

The effects of various drugs on the human aqueous humor flow were studied by the fluorophotometric method of Yablonski (topical fluorescein instillation). The effect of the beta-adrenergic blocker (Timolol) on aqueous humor flow and on intra-ocular pressure has been studied in ten normal eyes on the Fluorotron Master. We found that the acute decrease in intra-ocular pressure was equal to 1.39 +/- 0.44 microliter.min-1 for the Timolol treated eyes, and equal to 2.79 +/- 0.57 microliter.min-1 for the untreated eyes (Placebo). The difference between Timolol and Placebo was statistically significant (Student t-tested, and Wilcoxon W-tested). The fluorophotometric method is superior to the tonographic method by giving a more favorable condition to study the facility of outflow in steady physiological state. Our results are in good agreement with other authors and show Timolol to have little or no effect on the facility of outflow.

Aqueous Humor↗
PubMed1979

[Photochemistry of visual pigments (author's transl)].

Recent studies of the photochemistry of visual pigments are reported. Results obtained on rhodopsine and model compounds, by means of techniques based upon continous or pulsed excitation are compared. The mechanique of the primary photochemical step of the bleaching of rhodopsine is discussed. The process is occuring on a time scale of picosecond and a new concept of proton transfer followed by a conformation charge is opposed to the classical cis-trans photo isomerisation of the retinal moiety. The origin of the electrical response of the photoreceptor cells is still controversial.

Animals↗
PubMed1978

[Results of a double-blind study comparing the effects of timolol and pilocarpine in 110 patients with chronic open-angle glaucoma].

Following a seventeen weeks study including 110 patients with open-angle glaucoma, 81,8% of the patients treated by timolol, administered twice a day, had a satisfactory control of their intraocular pressure, against only 41,8% of those patients treated by pilocarpine, administered four times a day. The side effects liable to timolol are clinically reduced, in a osit with pilocarpine which is followed by a series of well-known subjective and objective signs often causing discomfort to the patients.

Aged↗