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Biomedical subjects

P Russell

Publications and source records attributed to P Russell.

At least 343 records · Page 19Linked to original sources
PubMed1982

Premature hypergonadotropic ovarian failure: clinicopathological study of 19 cases.

During the 5-year period 1977-1982, 57 patients below 35 years of age with secondary amenorrhea were assessed for hypergonadotropic (primary) ovarian failure. The histological findings within the ovaries as well as pertinent clinical and laboratory correlates are described. Nineteen had diagnostic ovarian biopsies performed. The importance of this technique is stressed. The ovaries of 14 patients showed absence of primordial follicles (true premature menopause); three others showed "resistant ovary syndrome" characterized by the presence of primordial follicles but little or no follicular development (including a case of galactosemia, in which the associated ovarian failure has been ascribed to follicular atresia). The remaining two revealed florid chronic perifollicular inflammatory reactions in the presence of both primordial and also developing follicles--one lymphoplasmacytic and the other granulomatous. The former has been previously suggested as evidence of an autoimmune process, but the latter has not hitherto been reported.

Adolescent↗
PubMed1982

Surgical division of right and left free wall accessory atrioventricular electrical connections in a child with incessant supraventricular tachycardia.

A child with Wolff-Parkinson-White syndrome developed incessant supraventricular tachycardia refractory to medical therapy and countershocks. Supraventricular tachycardias incorporating both right and left free wall accessory atrioventricular electrical connections were demonstrated. The more frequent, broad complex tachycardia utilised both the accessory connections and was independent of the atrioventricular node. The less frequent, narrow complex tachycardia utilised the atrioventricular node for anterograde conduction and the left sided accessory connection for retrograde conduction. Surgical division of the accessory connections restored normal sinus rhythm and eliminated supraventricular tachycardia.

Atrioventricular Node↗
PubMed1982

Placental candidiasis: report of three cases with a review of the literature.

Three new cases of placental candidiasis are reported. Two were associated with fetal cutaneous candidiasis and one with fetal systemic candidiasis. The systemic case was associated with an intrauterine contraceptive device. Infection of the placenta results in small 'granulomata' under the surface of the cord and a diffuse chorioamnionitis of the membranes and chorionic plate. In reviewing the 24 previously reported cases it can be seen that systemic. Candida infection of the fetus results in prematurity and death, infection can occur across intact membranes, and systemic candidiasis in the fetus is likely to be associated with an intrauterine device.

Adult↗
PubMed1982

The pathological assessment of ovarian neoplasms V: The germ cell tumours.

All neoplasms of the ovary encountered in a 25-yr study period of King George V Memorial Hospital were classified according to the World Health Organisation (WHO) Histological Classification of Ovarian Tumours. Of just fewer than 1700 tumours, 467 fell into the category designated as germ cell tumours: 4 dysgerminomas, one endodermal sinus tumour, one primary choriocarcinoma, 6 immature and 454 mature teratomas and one mixed malignant germ cell tumour. Two additional cases of gonadoblastoma with associated dysgerminoma were encountered and included for discussion. A detailed histological assessment is presented and the major clinical correlates are documented.

Adolescent↗
PubMed1981

The pathological assessment of ovarian neoplasms. IV: The sex cord-stromal tumours.

All neoplasms of the ovary encountered in a 25-yr study period at the King George V Memorial Hospital were classified according to the World Health Organisation (WHO) Histological Classification of Ovarian Tumours. Of just less than 1700 tumours, 168 fell into the category designated as sex cord-stromal tumours, this report analysing their major clinical and pathological correlates. A detailed histological assessment is then presented, including 4 cases of the recently separated subcategory of sclerosing stromal tumour of the ovary.

Adolescent↗
PubMed1981

In vitro production of basement membrane collagen by a clonal line of mouse lens epithelial cells.

The basement membrane is a structure of prime importance for the proper functioning of certain organs such as the lens and the kidney. Its inaccessibility and resistance to extraction, however, make an absolute determination of its composition difficult. The establishment of a cell line that synthesizes authentic basement membrane components in vitro would make basement membrane components more easily obtained, and would provide a controlled situation which could be more easily manipulated. In this report, a Balb/C mouse lens epithelial cell line was investigated. The cells were observed to undergo morphological transformations in vitro depending upon the cell density. As cell-cell contacts became prevalent, stellate cells organized into an epithelioid sheet. Later, elongate cells and lentoid bodies predominated in the culture. Thus, morphologically the cells mimicked the in vivo transition of the lens epithelial cells into lens fiber cells. Furthermore, the collagen(s) synthesized by these cells reacted specifically with affinity purified antibody directed against mouse type IV collagen. These morphological and immunological data lend credence to the concept that this lens epithelial cell line is an authentic replica of the in vivo situation.

Animals↗
PubMed1981

Mucinous ovarian tumors with giant cell mural nodules. A report of two cases.

Two cases are reported in young women of a variant of ovarian mucinous tumor with giant cell mural nodules. The first tumor was a predominantly proliferating mucinous tumor with a giant cell mural nodule adjacent to foci of haemorrhage and reactive vascular proliferation. No invasive carcinoma could be identified. In the second tumor, which was examined by electron microscopy, a sharp demarcation was observed between typical invasive mucinous carcinoma and areas which, on low-power examination, were indistinguishable from malignant giant cell tumor of soft parts. Closer examination revealed, in these latter areas, an intimate mixture of anaplastic, predominantly mononuclear tumor cells and multinucleate osteoclast-like giant cells. The histogenesis of these lesions is suggested as being reactive to the tumor cells or their products and is discussed with reference to similar tumors reported from the ovary and other sites in the body.

Adenocarcinoma, Mucinous↗