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Biomedical subjects

P Pilz

Publications and source records attributed to P Pilz.

51 records · Page 3Linked to original sources
PubMed1975

[Experimental study on the lymphatic and cerebrocervical drainage and changes therein caused by ultrasound (author's transl)].

After indian ink or ferritin are introduced into the cerebral hemispheres or subdural space these substances can be found in the deep cervical lymph nodes. The transport of these substances can be enhanced and accelerated by the treatment of deep cervical lymph nodes by ultrasound. Treatment of the paravertebral region with ultrasound after the introduction of ferritin or indian ink subdurally is followed by the appearance of these substances in the suprarenal gland, the testis, epididymis and the prostate gland where they are conveyed by the lymphatic pathways. Thirty minutes after the injection of ferritin into an afferent lymphatic channel of a deep cervical lymphatic node pretreated with ultrasound, ferritin can be found in the pia and arachnoid membranes of the cerebral hemispheres. Ultrasound treatment of the cervical lymph nodes not only seems to enhance the drainage of this substance from the brain but if the dose of ultrasound is high the direction of the lymphatic flow may be reversed.

Animals↗
PubMed1975

Primary leptomeningeal sarcomatosis. Clinicopathological report of six cases.

6 autopsy cases of primary leptomeningeal sarcomatosis are presented as a distinct nosological entity with a variable clinical picture and morphology in 5 males and 1 female. The clinical course from onset of symptoms till death ran for only a few weeks in most cases. 2 infants showed brain tumor symptoms and signs. 2 patients of advanced age presented a polyradiculoneuritic syndrome and 2 young adults had spinal cord compression symptoms and a mixed clinical form. In almost all cases, clinical symptoms and signs were for most of the course confined to one part of the neuraxis. The CSF was distinctly abnormal in all cases, showing elevated protein, depressed glucose and pleocytosis of variable extent. CSF sediment was investigated in 3 cases in all of which malignant tumor cells were found so a diagnosis of malignant meningeal tumor was made during life. Electron microscopy of CSF cells in 1 case confirmed the primitive character of the tumor cells. Complete autopsies revealed absence of any neoplasm outside of the CNS. Gross meningeal involvement was visible in all cases. Histologically, 3 tumor types were distinguished: polymorphic cell sarcoma, an undifferentiated form, and fibrosarcomatosis. Clinical data are analyzed in order to distinguish the condition from other neoplasms or infectious, especially tuberculous meningeal infiltrations. CSF cytology studies are considered the most useful step in clinical diagnosis. Neuropathological features are reviewed with stress on differentiation from malignant lymphomas of the CNS, diffusely spreading medulloblastoma, meningeal melanoblastosis and gliomatosis. The origin of meningeal sarcomatosis cells is briefly discussed. The use of the term "meningeal meningiomatosis" for this condition is deprecated.

Adolescent↗
PubMed1975

[Bacillary dysentery with involvement of the central and peripheral nervous system (author's transl)].

A man, age 50, fell ill with polyneuropathy followed by parkinsonism and organic psychosis and died in a shock 6 weeks later. Serologic examination suggested bacillary dysentery, but the patient had no diarrhoea. The neuropathological examination did not reveal any organic substrat of parkinsonism. Peripheral nerves showed mucoid degeneration, segmental demyelination and lymphocytic infiltration of peri- and endoneurium. Many Renaut bodies were found which seemed to arise from mucoid masses organized by cells of the endoneurium. Polyneuropathy and parkinsonism are well known neurological complications of bacillary dysentery and favour this diagnosis in accord with the serological findings.

Autopsy↗
PubMed1975

Moschcowitz syndrome with involvement of the central nervous system. Light optical studies on the genesis of hemolytic anemia and vascular changes.

The origin of hemolytic anemia, the histogenesis of vascular changes and the origin of prethrombotic lesion are discussed in a typical case of thrombotic thrombocytopenic purpura (TTP) with early neurological symptoms. The disease arose after exposure to a chloronaphtalene containing substance. In addition to the typical vascular changes of different age, early non-endothelialised and non obstructing aggregates of fibrin and thrombocytes are observed. Clusters of drop-like deformed erythrocytes and elongated leucocytes are attached to their surface. These changes do not appear to have been reported previously in TTP. The fresh thrombi are regarded as being hematologically active. Support for their supposed causal relationship to hemolytic anemia is given by experimental data by Brain and Bull.

Anemia, Hemolytic↗
PubMedDate not supplied

[The intermediate form of maple syrup disease].

A severely retarded and tetraspastic child died at the age of four years upon a respiratory infection with acidosis, disturbances of serum electrolytes and lactic aciduria. Brain autopsy showed a spongy degeneration and led to suspect an inborn error of amino-acid metabolism. These findings corresponded with the results of computer-tomography and were supported by post mortem amino-acid analysis. An intermediate variant of leucinosis was detected in an younger sister at the age of five months after cerebral convulsions and opisthotonic posture. The activity of the branched chain ketoacid decarboxylase in fibroblasts was reduced to 3-4% of normal. A protein restricted diet allowed a nearly normal cerebral development and improvement of computer-tomographic results. The similarity of clinical and biochemical data in both children indicate that a maple syrup urine disease was most likely the underlying disease in the older sister. Later performed electron-microscopical examinations of the older sister indicate that spongy degeneration of the central nervous system in leucinoisis is caused by a spongy myelinopathy, which is different from the alterations found in Canavan's disease, what could be pointed out for the first time.

Amino Acids, Branched-Chain↗
PubMedDate not supplied

Leigh's disease--several nosological entities with an identical histopathological complex?

Although Leigh's disease corresponds to a quite distinct histopathological complex, clinical and biochemical findings may be very divergent. By the description of classical and borderline cases and by the comparison with cases from the literature, it is suggested that Leigh's disease encompasses several nosological entities related to different disorders of the energy metabolism. They produce an identical histopathological complex. New evidence for a cerebral mitochondriopathy is also given.

Adult↗
PubMedDate not supplied

Fibromuscular dysplasia and multiple dissecting aneurysms of intracranial arteries. A further cause of Moyamoya syndrome.

A 16-year-old boy, who had sudden left-sided hemiplegia, died two weeks following onset of symptoms. A right carotid angiogram showed stenosis at the termination of the internal carotid artery. The middle cerebral artery had a beaded appearance and some of its branches were occluded. A basal "moyamoya" syndrome and transdural anastomoses were present. At autopsy, multiple intracranial dissecting aneurysms were found. Arteries of the body displayed fibromuscular dysplasia (FMD). The relevance of dysplastic changes of intracranial arteries and the relationship to moyamoya syndrome are discussed.

Adolescent↗
PubMedDate not supplied

Neuroepithelial and ectomesenchymal differentiation in a primitive pineal tumor ("pineal anlage tumor").

A primitive tumor of the pineal region in a 9-year-old girl led to death after 5 months of increased intracranial pressure with occlusive hydrocephalus. Histological investigation including immunocytochemistry revealed a broad spectrum of neuroectodermal differentiation with neuroblastic, neuronal, ependymal and retinoblastomatous features. Melanotic epithelial formations were similar to those of the so-called retinal anlage tumor and of the developing pineal gland. Striated muscle fibers indicated additional ectomesenchymal differentiation reminiscent of the close topographical relationship between neural crest and neural tube on the prosencephalic level of the pineal anlage. This developmental situation seems to be neoplastically reflected by the differentiation features of this tumor.

Brain Neoplasms↗