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Biomedical subjects

P Pichot

Publications and source records attributed to P Pichot.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Factorial structure of the Hamilton depression scale. I].

A development version (N I M H 67) of the Hamilton depression rating scale with 26 items was scored on 125 depressed inpatients recently hospitalized for a major non schizophrenic depressive illness. The data were obtained before any antidepressant treatment or after an adequate wash out period. A principal component factorial analysis with Varimax rotation was used. Computer simulations showed that only 2 factors were really outside the non significant range. A criterion is defined to allow the choice of an optimal saturation threshold for inclusion of an item in a factor. It assigns 25 of the 26 items of the scale to one of 2 independent factors: depression and anxiety-somatization.

Adolescent↗
PubMed1981

[Factorial analysis of the Hamilton depression scale, II].

A factorial analysis (principal components with Varimax rotation) was performed on 85 ratings of the Hamilton Depression Rating Scale obtained in 1979-1980 on inpatients with a major depressive illness. Using a replicable statistical technique, 4 factors were obtained. These factors do not overlap with those obtain on a similar sample with a similar technique nor with those obtained by other authors. It thus appears that there is no such thing as a factorial structure of this scale.

Depressive Disorder↗
PubMed1981

[The present state of the concept of depression (author transl)].

The author discusses the necessity of clarifying the classical dichotomy: endogenous vs. reactive or neurotic depression. The category of neurotic depression seems to be the most controversial. After mentioning the recent study by Klerman and al., he reports the results of an experimental study by Klerman and al., he reports the results of an experimental study conducted with a random sample of 100 French psychiatrists, who were asked to select, in a list of 32 criteria used in France for the diagnosis, those each considered important. A factor analysis of the answers leads to the description of three independent criteria-dimensions, the 100 psychiatrists being randomly distributed in the three dimensional space. The author concludes that each French psychiatrist has its own idiosyncrasic conception of the diagnosis of neurotic depression.

Adjustment Disorders↗
PubMed1979

[Visual tracking disorders in schizophrenia. Review of the literature and methodological considerations].

Since Holzman expressed the hypothesis that eye-tracking dysfunctions might be a genetic indicator of schizophrenia, the researches on the performances of schizophrenics in eye-tacking tasks have been numerous. The correlation between the results of all these researches leaves little doubt on the existence of eye-tacking dysfunctions in schizophrenics. But these distrubances must be precised. Up to now, the studies have used tests that were too complex in their interpretation (pendulum test) and they have been limited to a global appreciation of eye-tacking. To take into account the psychological parameters that may interfere with success in this type of tests, the coming researches should focus on elementary eye-motor activities.

Electrooculography↗
PubMed1978

[Prediction test of nomifensine prescription from symptomatic pre-therapeutic status (author's transl)].

Heighty two outpatients, suffering from reactive or neurotic depression have been treated with a daily 100 mg dose of nomifensine. The symptomatic status before treatment was appreciated by a self-rating scale, the Hopkins Symptoms Check List (HSCL). At the end of the study, the patient again filled out this same rating scale, and also a seven-score amelioration questionnaire. The investigator filled out this same questionnaire and a fourscore global impression scale. We tried to find out if by appreciating initial symptoms with the HSCL, it was possible to predict which patients would be responders to the treatment. The only highly significant result was obtained with a discriminant analysis, which combines 22 items of the pre-therapeutic HSCL and with which it is possible to predict the amelioration measured by the difference between the total pre- and post-therapeutic HSCL notations. The authors point out to the interest of this method in psychopharmacology.

Adjustment Disorders↗
PubMed1978

A double-blind multicentre trial comparing mianserin with imipramine.

1. Fifty-four depressive in-patients aged 18-45 yr, were treated at random, in double-blind conditions, with mianserin 60 mg daily or imipramine 150 mg daily in three divided doses for 4 weeks. Nitrazepam and diazepam were also allowed if necessary. 2. There was no significant difference in antidepressant efficacy between the two groups, as assessed by the rating scales of Hamilton, Beck and Overall, the Brief Psychiatric Rating Scale, and a global clinical rating. 3. The overall frequency of side-effects was significantly lower with mianserin than with imipramine. Autonomic symptoms increased in severity during treatment with imipramine, but not with mianserin. 4. the patients treated with imipramine had a fall in blood pressure which was not observed during mianserin treatment.

Adjustment Disorders↗
PubMed1977

[Mental disorders and professional determinants. Study of the time relationship between the beginning of professional life and the first disorder in teachers].

Analysis of the temporal relation between the beginning of mental illness and the beginning of professional life, according to a comparative anamnestic method applied to a group of teachers (N. = 94) and a matching control group of psychiatric paired out-patients (N. = 95). The results show that the distribution of illness prior to professional activity is linked with the diagnostic category and not with professional determinants, psychosis proving to be more impairing than neurosis. A high-risk age group for first incidence of psychotic disease was found.

Adult↗