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Biomedical subjects

P Petkov

Publications and source records attributed to P Petkov.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Nature and specificity of the auxilliary rabbit test in the diagnosis of swine fever].

Experiments were carried out with the aim to reveal the causes for the inhibited temperature reaction in rabbits to swine pest virus strain K in case of previous injection with virulent pest virus. It was established that in the serum of rabbits injected with virulent swine pest virus specific antibodies are found, which are capable to neutralize the lappinized K virus introduced later. This phenomenon which is specific enough and highly sensitive can be used with success as an auxiliary biological test in classical swine pest diagnosis.

Animals↗
PubMed1979

[Pathomorphological studies of experimental thiazole-80 poisoning in sheep].

Investigations on the pathomorphological changes occurring in the organisms of 4 sheep poisoned experimentally by varying Thiazole-80 doses applied orally were made. It was established macroscopically that after opening the rumen a smell of sulfuric hydrogen is felt. The abomasum was with rusty brown haemorrhages and liver distrophy as well as enlarged gall bladder were observed. The histological studies of parenchymal organs revealed vascular disturbances, hyperemia, oedema and intervascular haemolysis. A heavy diffuse nephrosis, hyaline and protein cylinders were found in the kidney cortex, while in the ganglial cells of medula oblongata were evident degenerative changes. Histochemically, in sheep poisoned by thiazole-80, a well expressed reaction to iron in the lungs, leptomeniges and distrophic hepatocytes were established. Glycogen quantity in the liver was considerably reduced.

Adrenal Glands↗
PubMed1978

[Clinical and pathomorphological studies of rabbits injected with virulent and lapinized swine plague virus].

Investigations were carried out to establish the clinical and morphological reactions in rabbits following the consecutive infection with the virulent Vratsa strain and the lapinized K strain of the swine fever virus. It was found that although the virulent strain did not cause a thermal response there were morphological lesions in the body of the rabbits, characterizing the presence of an immune response. The latter was shown to inhibit the thermal reaction in the animals after infecting with lapinized strain. It is stated that such inhibition of the thermal reaction which is typical for strain K is invariably generated if the lapinized virus is injected 120 hours after the injection of the virulent virus.

Animals↗
PubMed1978

[Risk factors in ischemic heart disease patients].

Four hundred sixty patients with ischemic heart disease (IHD) were examined: 226 of them--with myocardial infarction; 38--stenocardia, 196--myocardiosclerosis. With age advancing all forms of IHD increase. The incidence of the followed up risk factors progessively increases. Hypertension has the greatest share--56.30 per cent out of all the subjects examined. Second place as regards incidence is occupied by the emotional stress--46.52 per cent. Further they are as follows: heredity--38.91 per cent; tobacco smoking--34.57 per cent, sedentary life--32,83 per cent, obesity--31.52 per cent, overfeeding--30 per cent, hypercholesterinemia--30 per cent, diabetes--17.61 per cent. The significance of the indicated risk factors alarmingly grows, consideration given to their combined effect. An average of 3.18 risk factors fall on patient. In patients with myocardial infarction they are more frequent and appear at an earlier age. Such an accumulation of the noxae upon the contemporary man requires the complex effors of the whole society.

Adult↗
PubMed1976

Ultrastructure of B-cells of Langerhans islets in rats after the administration of L-leucine.

The results of studies with electron microscope supported the earlier biochemical findings on the stimulation of insulin secretion with the aid of L-leucine. The changes of the cell organelles of B-cells showed that both the synthesis and the release of insulin were activated, while the secretion by specific granules was unchanged. The stimulation of B-cells was accompanied by numerous membrane-like structures ("myelin-like figures") which were presumably formed from the endoplasmic reticulum.

Animals↗