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Biomedical subjects

P Peters

Publications and source records attributed to P Peters.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Central hemodynamics of a new positive inotropic substance, adibendan. Data from a dose-finding study].

Central Hemodynamics from the New Positive-inotrope Substance Adibendan/An open dose-finding study We investigated the influence of Adibendan which is a new phophodiesterase inhibitor on central hemodynamics in an open dose-finding study. 10 patients with chronic heart failure NYHA II-IV (mean age 67 +/- 5 years) got Adibendan i.v. A maximum increase in cardiac index from 2.3 +/- 0.5 to 3.2 +/- 0.5 l/min.m2 (p less than 0.001) was seen after a cumulative dosage of 0.916 +/- 0.571 mg at a time interval of 107 +/- 43 min after injection of the first dosage of 0.125 mg. There was a pronounced increase in stroke volume index from 30 +/- 6 to 40 +/- 8 ml/m2 (p less than 0.01). Heart rate raised by 5% which was not significant. Systemic vascular resistance dropped by 30% from 1693 +/- 720 to 1177 +/- 292 dyn.s.cm-5 (p less than 0.05), pulmonary vascular resistance by 39% from 755 +/- 273 to 463 +/- 199 dyn.s.cm-5 (p less than 0.001). Blood pressure and right atrial pressure did not alter. Mean pulmonary artery pressure dropped by 14% from 37 +/- 7 to 32 +/- 11 mmHg. We conclude that Adibendan improves cardiac index markedly and causes a modest decrease in mean pulmonary artery pressure.

Aged↗
PubMed1989

Acute effects of enoximone in chronic heart failure.

In 19 patients with chronic heart failure in NYHA stages III and IV, hemodynamic measurements were made using a Swan-Ganz catheter before and 15 and 30 min after intravenous administration of enoximone. Group A (n = 10) received 1.0 mg of enoximone/kg of body weight and group B (n = 9) received 1.5 mg of enoximone/kg of body weight. In group A, there was a rise in the pulse rate of 13% and in the cardiac index of 13% with unchanged stroke volume index. At constant mean arterial pressure, the mean right atrial pressure fell by 28%, the mean pulmonary arterial pressure by 11%, the total peripheral resistance by 13%, and the total pulmonary resistance by 21% after 30 min. In group B, the pulse rate rose by 9.8%, the mean blood pressure by 2.7%, the cardiac index by 31.4%, and the stroke volume index by 18.4% 30 min after administration of enoximone, whereas a fall in the mean right atrial pressure by 57.4%, the mean pulmonary arterial pressure by 28.6%, the total peripheral resistance by 26.0%, and the total pulmonary resistance by 45.3% could be shown. At a low dosage of enoximone, the vasodilatory effects of this substance are most prominent, whereas an increase in the pumping performance of the heart could be clearly demonstrated in higher dose ranges.

Aged↗
PubMed1989

[Effect of pimobendan on peripheral hemodynamics].

Peripheral hemodynamics and some metabolic parameters were studied in 20 patients with coronary artery disease (x = 59 +/- 9 y) and in 20 healthy volunteers (x = 25 +/- 3 y) at rest and after isometric handgrip exercise both before and after administration of pimobendan or placebo using a randomized, double-blind study. Forearm blood flow was measured using venous occlusion plethysmography. In pimobendan treated patients and volunteers an increase in forearm blood flow between 9% and 38% could be noticed. The increase in forearm blood flow was significant in comparison to placebo only, in volunteers under resting conditions. Heart rate increased significantly by 14-19% in all groups after administration of pimobendan. There were no alterations in blood pressure. Local resistance in forearm fell by 13-22%. Pimobendan did not change metabolic parameters.

Adult↗
PubMed1988

[Gonadotropin resistance in Rothmund-Thomson syndrome].

A case of Rothmund-Thomson syndrome of a 24-year old woman with primary amenorrhoea is presented. This autosomal recessive disorder is characterised by atrophy, hyperpigmentation and teleangiectasiae of the skin, furthermore by juvenile cataracts and congenital bone defects as saddle nose. Endocrinologic and morphologic parameters suggest a resistant ovary syndrome as cause of this hypergonadotropic hypogonadism.

Adult↗
PubMed1988

[Fiber in the diet--certainties and speculation].

This report defines dietary fibre and summarizes its effects on dental, gastrointestinal and metabolic diseases. A higher intake of dietary fibre is important in prophylaxis of caries, paradentosis, constipation, diverticulosis, colon cancer, diabetes and hypercholesteraemia. An ideal preparation must have the following abilities: It should be coarse, hard and swallowable and without cariogenic sugars in order to prevent dental diseases. It should be a mixture of several kinds of fibre getting water binding capacity and bile acid binding capacity. Mechanical crushing and heatening of fibre are to be avoided. The preparation should not contain phytic acid.

Colonic Neoplasms↗
PubMed1988

[Aggressive mediastinal fibrosis, a rare cause of superior vena cava obstruction--case report and review of the literature].

An aggressive mediastinal fibrosis was found to be a cause of superior vena caval obstruction in 1 to 2% of patients. Symptoms can be discrete for a long time, but the progressing disease can cause many symptoms. A 56-year-old man who, for half a year, suffered from thoracic pain during deep inspiration, and then rapidly developed superior vena caval obstruction caused by aggressive mediastinal fibrosis is discussed. The operative treatment consisted in complete replacement of the superior vena cava.

Fibrosis↗
PubMed1986

[Peripheral hemodynamics and metabolic parameters influenced by amrinone at rest and following handgrip stress].

Peripheral hemodynamics and metabolic parameters were studied in 12 healthy volunteers (mean = 24.6 years) and in 12 patients with coronary artery disease (mean = 51.1 years) at rest and after isometric handgrip exercise both before and after application of amrinone (1.5 mg/kg body weight i.v.). Amrinone produced a significant decrease in diastolic blood pressure during handgrip in patients and in volunteers by 10%. Heart rate increased by 4 to 8%. After application of amrinone there was a pronounced increase in forearm blood flow at rest by 50% and after handgrip by 30%. Amrinone is an effective vasodilator without altering systolic and mean arterial blood pressure or heart rate strongly. Amrinone did not influence metabolic parameters.

Adolescent↗
PubMed1985

A monoclonal antibody-based immunoradiometric assay for detection of circulating antigen in Bancroftian filariasis.

A monoclonal antibody designated Gib 13 has been used in an immunoradiometric assay (IRMA) to detect circulating antigen in the sera of Wuchereria bancrofti-infected subjects from an endemic area of Papua New Guinea. A clear association between the presence of patent infection and the Gib 13 target epitope in serum was established because 93% of microfilaremic individuals were antigen-positive. Moreover, there was a significant correlation between levels of serum antigen and blood microfilarial counts. Detection of circulating antigen in amicrofilaremic subjects with acute symptoms of lymphatic filariasis, and 53% of asymptomatic amicrofilaremic subjects, but not in nonendemic controls, suggests that the Gib 13 IRMA will also be of value in the diagnosis of occult filariasis. However, as in all IRMA based on detection of potentially immunogenic molecules in man, antibodies can be expected to be the major contributor to reduced sensitivity of the assay.

Adolescent↗
PubMed1984

Parasitologic and clinical features of bancroftian filariasis in a community in East Sepik Province, Papua New Guinea.

Bancroftian filariasis has been reported in several areas of Papua New Guinea. The epidemiologic features and natural history of Wuchereria bancrofti infection in this geographic region, however, have not been well-defined. The objective of this study was to assess the parasitological and clinical features of bancroftian filariasis in a community in East Sepik Province, Papua New Guinea. In a village of 99 individuals, the overall prevalence of microfilaremia was 68%. The microfilarial carrier rate was high in those less than or equal to 10 years (62%), remained elevated in the 11-20, 21-30, and 31-40 age groups (42-55%), and peaked in subjects greater than or equal to 41 years old (90%). The geometric mean level of parasitemia in all subjects with patent infection was 3,198 microfilariae/ml blood. This value was 78 parasites/ml in the less than or equal to 10-year-old age group, increased to 1,753 in 21 to 30-year-olds and was markedly elevated in subjects greater than or equal to 41 years old (6, 792 microfilariae/ml). Acute symptoms of filariasis (lymphadenitis and lymphangitis) were initially noted in individuals between the ages of 11 and 20 years (30%). Obstructive disease, manifested as elephantiasis and hydroceles, was present in 64 and 79% of 31-40 and greater than or equal to 41-year-olds, respectively. These data suggest that intense transmission of W. bancrofti infection occurs at an early age in this area of East Sepik Province; patent infection remains high in older age groups. Irreversible lymphatic obstruction develops 20-30 years after initial infection and may be associated with either amicrofilaremia or microfilaremia.

Adolescent↗
PubMed1983

A new transvenous lead for both atrial and ventricular pacing.

A new transvenous tined unipolar lead (Medtronic SP 342) has been implanted in 56 patients; 35 leads were positioned in the atrium and 34 in the ventricle. The lead comprises a trifilar DBS-conductor within an insulation of polyurethane, four symetrically placed polyurethane tines furnished with scallops and a platinum-iridium ring-tipped electrode. The scallops in the tines ensure flexibility and a small effective diameter of the lead which makes the choice of vein less critical than with most previous tined leads. It allows use of the same normally sized vein for a second lead for dual-chamber sensing pacing. Mean atrial and ventricular electrogram amplitudes (+/-SD) were 4.6 +/- 1.2 mV and 8.8 +/- 4.4 mV; mean atrial and ventricular stimulation thresholds were 0.8 +/- 0.3 V and 0.4 +/- 0.2 V; and mean atrial and ventricular lead impendances were 415 +/- 114 ohms and 456 +/- 105 ohms, respectively. The results of this study show that the SP 342 lead is useful especially in dual chamber systems.

Adolescent↗
PubMed1981

Is selective therapy of recurrent nephrolithiasis possible?

We evaluated, in 128 patients with recurrent nephrolithiasis, the efficacy of special treatment programs for some of the common causes of nephrolithiasis, chosen on the basis of their ability to correct underlying physicochemical and physiologic derangements. Therapy included sodium cellulose phosphate for 18 patients with absorptive hypercalciuria, thiazide diuretics for 27 patients with absorptive hypercalciuria and for 10 with renal hypercalciuria, orthophosphate for eight patients with hypophosphatemic absorptive hypercalciuria, allopurinol for 21 patients with hyperuricosuric calcium oxalate nephrolithiasis, thiazide and allopurinol for 26 patients with absorptive hypercalciuria with hyperuricosuria, and high fluid intake and/or low calcium diet for 22 patients with normocalciuric nephrolithiasis. Patients in all seven groups had a significant reduction in stone formation during 1.70 to 3.37 years of treatment, as compared with the pretreatment period of three years. Remission was found in 70 to 91 percent of patients and reduced stone formation rate was encountered in 88 to 100 percent. Each treatment program produced a significant decline in stone formation rate from 1.90 to 2.28 stones per year to 0.09 to 0.55 stones per year. The actual number of stones formed during treatment was significantly lower than the number predicted from the pretreatment frequency of stone formation (less than 26 percent). The results provide evidence supporting a selective approach to therapy of nephrolithiasis.

Allopurinol↗