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Biomedical subjects

P Peltier

Publications and source records attributed to P Peltier.

At least 55 records · Page 3Linked to original sources
PubMed1986

Immunohistochemical antigenic expression and in vivo tumor uptake of monoclonal antibodies with specificity for tumors of the gastrointestinal tract.

Two monoclonal antibodies with specificity for carcinoembryonic antigen and Ca 19-9 gastrointestinal tract tumor associated antigens were infused after iodination with 125I and 131I, respectively, in six patients 3 days and in one patient 4 days before radical surgery for colon or rectal carcinoma. Biopsy specimens from tumor, normal colon, fat, muscle, and skin along with a blood sample were excised at surgery and counting was performed for gamma emission. Fragments were then studied by two independent pathologists for immunohistochemical expression of corresponding antigens using the avidin-biotin peroxidase complex. A correlation study was thereafter performed between the amount of antibody bound in vivo, expressed as the percentage of injected dose per gram of tissue and the quantitative expression of tumor associated antigens, taking into account both the percentage of cells expressing the antigen and intensity of staining. For this limited number of patients a good correlation was found between amount of targeted antibodies and amount of expressed antigens. For carcinoembryonic antigen, r values were 0.69 and 0.90 for each pathologist (with an r value of interobserver correlation of 0.74); for Ca 19-9, values of 0.78 and 0.84 were obtained for each observer, with an interobserver r value of 0.97. Based on this limited study, it may be assumed that the possibility of imaging a given tumor is in part correlated to intensity of antigenic expression at the tumor site; other parameters, like tumor vascularization and blood flow for instance, are, however, to be considered for accessibility of antibodies to corresponding antigens.

Antibodies, Monoclonal↗
PubMed1986

[Methodological problems in the determination of microalbuminuria].

We have performed 7 different urinary collections to assess albumin excretion rate in insulin-dependent diabetics. The night and the 24 hours urine collections were more accepted than the others. For albumin excretion rate there was no correlation among the different collections. So, the albumin excretion rate must be done always on the same sample for one patient and be repeated to confirm pathological values.

Adult↗
PubMed1986

[Pleuropulmonary disease caused by Pasteurella multocida. Study of 9 cases. Review of the literature].

Nine cases of pleuro-pulmonary infection due to Pasteurella multocida were observed over an 11 year-period (1974-1984) occurring in seven men and two women, with a mean age of 65 (range: 47-80 years). There were 4 pneumonias and 5 cases of empyema, occurring on three occasions after septicemia. There was a background of depressed immunity in 7 cases: alcoholic cirrhosis (4 cases), blood dyscrasias (2 cases), breast cancer (1 case); and of a chronic broncho-pulmonary pathology in two cases. Animal inoculation was present in six cases but only one case of pneumonia followed injury by an animal (cat scratch). The clinical, radiological and epidemiological data of these nine cases were similar to those in the literature (forty-five published cases). There was a zero mortality in our (from 30%) in the literature. Pasteurella multocida is an opportunistic organism, noncommensal in man, producing pulmonary infections in subjects with generalised or localised diminished resistance, the portal of entry being airborne (indirect animal contact) or haematogenous. The organism is nearly always sensitive to Penicillin and other B-lactamines. The gravity of infections to Pasteurella multocida relates to the degree of decompensation or severity of the underlying disorder.

Aged↗
PubMed1986

[Finger plethysmography for studying the blood rheological and hemodynamic components of an acrosyndrome].

Digital plethysmography allows investigation of maximum digital pulse (M.D.P.) after immersion of hands at 45 degrees C over three minutes. It is correlated with digital arterial blood flow. Reactivity to cold is determined from the ratio M.D.P./digital pulse after local and body cooling over 3 minutes. Tests were performed on 65 controls, 69 patients with idiopathic Raynaud's syndrome, 12 with scleroderma, 10 with digital arteritis and 15 with Raynaud's phenomenon secondary to hemorheologic affections. Maximum digital pulse was significantly decreased in patients with digital arteritis and scleroderma. The M.D.P. was normal in controls and patients with idiopathic Raynaud's syndrome, and was significantly increased in patients with a rheologic Raynaud's phenomenon. Digital artery reactivity differentiates the populations studied: it was maximum in patients with scleroderma, moderate in controls and patients with isolated digital arteritis and marked in patients with idiopathic Raynaud's disease and those with rheologic Raynaud's phenomena.

Adult↗
PubMed1984

[Localization of pheochromocytomas by scintigraphy with meta-iodobenzyl guanidine. Comparison with computed x-ray tomography].

Meta-iodobenzylguanidine was synthesized, radiolabelled with I 131 or I 123 and injected to 28 controls and 7 patients totalling 13 foci of pheochromocytoma. The tumour was located in one adrenal gland in 3 cases, in both adrenal glands in 1 case, and between the aorta and the vena cava in 1 case; 2 were malignant with metastases. Scintigraphy was negative in all controls, whereas all pheochromocytomas were clearly demonstrated 24 h after injection, except one regarded as non functional due to necrosis. By comparison, CT readily showed the tumour in 7 cases, showed it only thanks to scintigraphic guidance in 4 cases and failed in 2 cases. It is concluded that scintigraphy with meta-iodobenzylguanidine provides a safe and reliable means of locating a wide range of pheochromocytomas.

3-Iodobenzylguanidine↗
PubMed1984

[Reliability of pulmonary perfusion and ventilation scintigraphy compared with angiopneumography for the diagnosis of pulmonary embolism].

Fourty-six patients suspected clinically of having a pulmonary embolism (PE) were investigated by angiopneumography (AGP) and perfusion (99m-Tc aggregates) and ventilation (99m-Tc colloid) scintigraphy (SPV Tc). Findings were assessed under blind conditions. A positive diagnosis of pulmonary embolism was made in 19 patients. The SPV Tc was considered as positive if perfusional deficiencies were greater than ventilatory defects, and this was evaluated as such in 23 cases (19 true and 4 false positives). False negatives were not observed. The 4 false positive results corresponded to scintigraphic anomalies suggestive of pulmonary emboli subsegmental in size; true positives were either subsegmental (8), segmental (6) or lobar (5). Sensitivity of the SPV Tc wis therefore 100%; its specificity, all results considered was 76%, but was 100% if only images of lobar or segmental lesions are considered.

Aerosols↗
PubMed1982

The use of Doppler flow studies in the diagnosis of giant cell arteritis. Selection of temporal artery biopsy site is facilitated.

Sixty patients, for whom a diagnosis of giant cell arteritis (GCA) was clinically suspected, underwent Doppler study as a method of guiding temporal artery biopsy. In group A (23 patients with normal Doppler results), only one had a positive histological lesion. In group B (14 patients with discrete Doppler abnormalities), none had inflammatory lesions. Twelve of the 23 patients in group C (stenosis or thrombosis) had a biopsy result corresponding to GCA. Forty-three percent of the patients in group C had degenerative arterial lesions leading to a decrease in blood flow. There is a small probability, according to this preliminary study, of diagnosing GCA by artery biopsy even when findings from the ultrasonic examination are normal or only slightly irregular. However, a negative Doppler result should in no case exclude a biopsy if the clinical picture is suggestive.

Aged↗
PubMed1982

[Pulmonary infection with Pasteurella multocida in an immuno-deficient patient (author's transl)].

A seventy-seven-year-old woman, under intermittent treatment with chlorambucil for chronic lymphocytic leukemia, developed acute pneumonia (diffuse interstitial pneumonitis) due to Pasteurella multocida. No direct traumatism had been caused by her cat. Bacteriologic study material was obtained by guided transtracheal distal bronchial brushing and washing. Therapy with tetracyclin was rapidly successful. Pasteurella multocida is an opportunistic organism which can be responsible for severe infections in high-risk patients.

Aged↗
PubMed1982

[Comparative study of the bacteriologic value of samples taken by transtracheal aspiration or fiberoptic bronchoscopy].

To evaluate two methods of obtaining lower respiratory tract secretions, fiberoptic bronchoscopy (FB) and transtracheal aspiration (TA) were performed in ten patients. FB used an open-end brush-in catheter. TA was performed as described by Pecora. TA gave significantly better sensitivity and specificity (3/5 and O false positive results respectively) than FB (2/5 and 5 false positive results). TA gives specimens which reflect the bacterial flora of the lung more reliably than those taken during FB.

Biopsy, Needle↗
PubMed1982

[Pulmonary fibrosis in ankylosing spondylitis. Five new cases (author's transl)].

The most common thoracic finding in ankylosing spondylitis (AS) is ankylosis of the costovertebral joints with severe limitation of chest expansion inducing a restrictive syndrome pleural and pulmonary fibrosis can occur during the course of the disease. One-hundred record of patients with AS were reviewed. Five had pleuro-pulmonary involvement. This always included pachypleuritis, usually apical. Roentgenographic pulmonary changes were infiltrates or fibrobullous lesions. Pulmonary function tests showed restriction in four cases, obstruction in one case, and a decreased diffusing capacity in all five cases.

Adult↗
PubMed1982

Guided transtracheal distal pulmonary brushing-washing: diagnosing acute pneumonia in high-risk patients.

Transtracheal brushing-washing of distal pulmonary lesions was performed in 20 patients. Specimens were obtained by brushing and washing through a catheter placed in the pulmonary lesion with the aid of a guide. In nine patients pathogenic organisms were isolated. In the other 11 patients infectious studies of the specimens were negative, five of the patients (true-negatives) showing no infection and six (false-negatives) showing infection. Serious complications were uncommon, but one patient, who had diffuse intravascular coagulation, died. This procedure seems to represent an advance over transtracheal aspiration and is an effective alternative to such invasive methods are transthoracic lung aspiration and pulmonary biopsy.

Adult↗
PubMed1982

[Complementary studies in acute bronchopulmonary infections except tuberculosis].

Development of a strategy for the investigation of pulmonary infectious disease is aimed at identifying the organism responsible for the infection in order to prescribe the appropriate antibiotic therapy. Factors involved in the choice of a method are the underlying condition (healthy, high risk or immunodepressed subject), the type of infection (primary, secondary), the technical abilities of the medical and bacteriological team and finally the value of the different techniques of isolation. The latter must provide a specimen which is not contaminated by the oropharyngeal flora. Their reliability involves definition of a reference method which can be used to test the other techniques in comparison, and requires comparison of the bacteriological results obtained with clinical and radiological data as well as the results of the resultant therapeutic decision. Indirect methods of investigation (blood cultures, serological studies) are relatively unfruitful. Criteria of value of direct methods of investigation are defined and applied to each method (expectoration, transtracheal aspiration, bronchial fibroscopy, transparietal puncture). On the basis of data in the literature and their own results, the authors undertake an analytical then comparative (in a given patient) study of the different methods, and identify their indications.

Biopsy↗
PubMed1982

[Diffuse pulmonary amylosis. Apropos of 2 cases associated with Waldenstrom's disease].

Diffuse pulmonary amyloidosis is rarely reported in systemic amyloidosis. We report two patients with Waldenström's macroglobulinemia in whom pulmonary amyloidosis was revealed by a diffuse interstitial syndrome without severe functional impairment. Amyloid pulmonary deposits are anatomically frequent and are often associated with cardiac amyloidosis. They must be evoked more frequently in the diagnosis of diffuse interstitial patterns, particularly in patients with primary amyloidosis or dysglobulinemia.

Aged↗