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P Patterson

Publications and source records attributed to P Patterson.

At least 145 records · Page 8Linked to original sources
PubMed1994

Expression of AbdB-type homeobox genes in human tumors.

BACKGROUND: Homeobox (HOX) genes of the ANT-C/BX-C type control rostral-caudal patterning during embryogenesis. Previous work has shown that tissues express unique HOX gene expression profiles that persist upon transplantation to distant sites. These properties suggest that analysis of HOX genes may be useful for the diagnosis and evaluation of primary and metastatic tumors. EXPERIMENTAL DESIGN: We analyzed normal and neoplastic tissues for the expression of three AbdB-type HOX genes; HOXD10, HOXA9, and HOXC9 to evaluate three hypotheses: (a) that tumors express HOX genes found in their tissue of origin, (b) that metastatic tumors continue to express HOX genes found in the primary tumor, and (c) that the level of HOX expression is related to tumor grade. RESULTS: Malignant tumors gave consistent patterns of HOX gene expression that paralleled their tissues of origin. Normal kidney and Wilm's tumors expressed all three genes. Other renal tumors expressed distinct permutations of the three genes. One epithelial Wilm's tumor expressed only an aberrant 0.3 kb HOXD10 transcript. Outside of the kidney, HOXD10 was most characteristic of uterine tumors, HOXA9 of colonic adenocarcinomas, and HOXC9 of two groups of tumors: neoplasms derived from neural crest and mesenchymal tumors derived from intermediate mesoderm. Metastatic tumors retained their HOX gene expression profiles and did not express HOX genes transcribed at the site of metastasis. While modulation of HOX gene expression was observed in some poorly differentiated tumors this was not a consistent measure of tumor grade. CONCLUSIONS: HOX gene profile was a reliable indicator of histologic subtype in a variety of tumors and in selected cases provided useful diagnostic information. Persistent expression in metastatic tumors confirmed that HOX expression profiles are potentially useful for diagnosing tumors of unknown origin. Continued analysis of the relationship between level of expression and tumor grade/behavior is indicated.

Adenocarcinoma↗
PubMed1994

Patterns of placental injury. Correlations with gestational age, placental weight, and clinical diagnoses.

Given the dependence of the fetus on adequate placental function, one might predict that specific placental lesions would be associated with distinct pregnancy outcomes. To test this hypothesis, we examined 609 nontwin placentas and explored the relationship between histologic diagnosis and the following variables: gestational age at delivery, placental size, and selected categories of clinical disease. Five separate patterns of placental injury were examined. Two lesions were particularly frequent prior to 37 weeks' gestation: increased intervillous fibrin, which was most common in early preterm placentas (20 to 31 weeks), and membrane hemosiderin, which was increased in both early and late preterm placentas (32 to 36 weeks). Three lesions--maternal vasculopathy, villitis of unknown etiology, and increased intervillous fibrin--were associated with retarded fetal and placental growth. Only maternal vasculopathy was significantly increased in placentas from pregnancies with gestational hypertension, while two other lesions--villitis of unknown etiology and increased intervillous fibrin--were appreciably increased with nonhypertensive chronic antenatal abnormalities.

Female↗