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Biomedical subjects

P Pacini

Publications and source records attributed to P Pacini.

At least 109 records · Page 6Linked to original sources
PubMed1978

[Epithelium of the human fallopian tube under a scanning electron microscope].

The changes of the human fallopian tube epithelium in the different phases of the menstrual cycle, during tubal pregnancy and in the postmenopausal period have been studied by scanning electron microscopy. During sexual life, the most evident modifications occur in the nonciliated cells. After ovulation they show dome-shaped apices covered by secretory material which partly masks the microvilli.

Adult↗
PubMedDate not supplied

Prevalence of HCV antibodies in health-care workers from northern Italy.

The prevalence of HCV antibodies was assessed in 407 health-care workers and in 253 control subjects by means of immunoassays based on recombinant antigens. The seroprevalence in the study group was fairly low (1.2%) and not statistically different from that of controls (0.8%). The relation of HBV and HCV infections was evaluated in 83 health-care workers and in 82 controls: in both groups anti-HCV positivity was weakly related (p less than 0.05) to the HBV infection. HCV infection was associated with working in high risk wards (4/5 cases) and with report of accidental needle pricks (4/5 cases). As evaluated by means of the available markers, HCV infections in health-care workers seem to be rare.

Adult↗
PubMedDate not supplied

Scanning electron microscopy of the human vas deferens epithelium following oestrogenic treatment.

Human vas deferens from 4 subjects submitted to a prolonged oestrogenic therapy was observed with SEM. The microvilli, characterizing the cell apices in the normal cases, are considerably reduced in number and length. Some cells show thin laminar folds (microplicae) arranged in a complicated labyrinth in the central zone of the apocal surface. The globular apical extrusions characterizing the normal vas deferens secretory cells are no longer present. These observations indicate the decrease of the absorbent capacity and the fall of the secretory function in the vas deferens epithelium following oestrogenic treatment.

Epithelium↗
PubMedDate not supplied

Vas deferens and seminal vesicles epithelium after castration: a SEM study.

The effects of orchiectomy have been observed, with SEM, on the vas deferens and seminal vesicles epithelium of 20 adult albino rats. The inner surface of castrated rat vas deferens shows a reduction in height and thickness of the mucosal folds and, at the cellular apex, a remarkable decrease of the microvilli as well as the disappearance of the secretory blebs. At the level of the seminal vesicles also, castration affects both the mucosal folds, which are flattened, and the cellular apical features, with the reduction of the microvilli and the disappearance of the secretory granules. Such changes give evidence in favour of a decrease in the absorptive capacity and a suppression of the secretory activity of these epithelia, as a consequence of the fall of androgen levels.

Animals↗
PubMedDate not supplied

Long-term sequelae of breast cancer surgery.

BACKGROUND: Quality of care is today a major issue in oncology, and much attention is given to research on the outcome of breast cancer care. Too little attention has been devoted in the scientific literature to the consequences of treatment in long-term survivors, and in particular to the possible side effects. The specific aim of this contribution is to present population-based data about the long-term impact of breast cancer care in women who had an incident cancer in 1985/1986. PATIENTS AND METHODS: The cases are 476 breast cancers incident in the City of Florence in 1985-86. Women still living 5 years later were invited to have an interview and a physical examination. Lymphedema, peripheral nerve lesions and damage to the shoulder were assessed. RESULTS: Of the 346 5-year survivors, 238 accepted our invitation: 35.2% of the women reported some early postoperative sequelae, 30.2% had a chronic lymphedema and 18.9% a shoulder deficit. Comparing breast-conserving surgery with radical mastectomy, the risk of chronic lymphedema (OR = 1.62; 95% C1: 0.91-2.88) and other lesions was higher for women who had a radical surgery. Women who had a breast-conserving surgery more often reported an early lymphedema (OR = 1.60; 95% Cl: 0.88-2.88). CONCLUSIONS: The proportion of women who complained of (or manifested at the physical examination) a minor or major disability of the arm in our study was high. The impact of these functional problems in terms of quality of life should also be assessed, but it is our impression that there is need for much greater attention to the issue of long-term survivor sequelae.

Adult↗
PubMedDate not supplied

Risk of endometrial cancer in breast cancer patients under long-term adjuvant treatment with tamoxifen.

AIMS: To evaluate the relative risk of endometrial cancer with respect to the expected underlying incidence in breast cancer patients undergoing long-term adjuvant tamoxifen therapy. METHODS: A total of 1010 postmenopausal breast cancer patients receiving adjuvant tamoxifen and with a first negative endometrial ultrasonography (cutoff for abnormal endometrial thickness >5 mm) were followed by annual transvaginal ultrasonography. Abnormal endometrial thickness prompted an outpatient endometrial biopsy or curettage under anesthesia in the case of cervical stenosis and increasing endometrial thickness. The standardized incidence ratio (SIR) with respect to underlying incidence was determined. RESULTS: A total of 1,010 eligible subjects who had been receiving tamoxifen for an average of 51 months were enrolled and followed for a total of 2,361 patient-years between January 1993 and December 1996. Five cases of endometrial cancer were observed in the study period: 1 was detected at screening, and 4 were diagnosed for vaginal bleeding in the interval between screening examinations. SIR was 4.0 (95% confidence interval, 1.3-9.4) and increased to 4.8 (CI, 1.6-10.5) when the single cancer detected at first screening was considered as incident. CONCLUSIONS: This study adds evidence to the hypothesis that long-term tamoxifen treatment may be responsible for a relevant increase in the risk of developing endometrial cancer. Surveillance based on endometrial ultrasonography was poorly sensitive, but the favorable stage at diagnosis of screen-detected or interval endometrial cancers does not support a more aggressive screening approach.

Aged↗