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Biomedical subjects

P Pacini

Publications and source records attributed to P Pacini.

At least 73 records · Page 4Linked to original sources
PubMed1986

Cost-effectiveness of chest X-ray follow-up of patients treated for seminoma of the testis.

The authors report on a consecutive series of 253 cases of seminoma of the testis followed with periodic chest X-ray examinations from a minimum of three to a maximum of 27 years. The detection rate of asymptomatic intrathoracic metastases (ITM) was considered together with the costs of the follow-up procedure. Chest X-ray follow-up is not advisable beyond one year from primary treatment, since most (14 of 18) ITM occur in the first year, the detection rate of ITM beyond this date is too low (0.11% patients/year), and the related costs are too high (over $130,000 per ITM detected). Chest X-ray follow-up is questionable even in the first year after primary treatment for Stage I cases because of the low detection rate (1.38% patients/year) and the high costs (over $14,000 per ITM detected), whereas it appears to be opportune in Stages IIA and IIB.

Cost-Benefit Analysis↗
PubMed1986

Symptomatic recurrences of carcinoma of the rectum and sigmoid. The influence of radiotherapy on the quality of life.

One hundred forty-three patients irradiated for locoregional recurrences after curative surgery for cancer of the rectum and sigmoid were studied retrospectively. An analysis was made of the symptomatic response and survival in the total series and in three subgroups treated with different dose levels (40 Gy or lower, between 40 and 50 Gy, 50 Gy or higher). The symptom-free period was calculated as percent of the overall survival. Symptomatic control was obtained in 80.4 percent of the cases, and the crude patient survival rate was 17.5 percent at two years. No significant difference was found in the three subgroups treated with different dose levels. The cumulative time/patient asymptomatic periods in the total series and in the three subgroups were 31.5, 30.2, 31.8, and 31.9 percent respectively, of the survival period.

Adult↗
PubMed1986

Patterns of axillary metastases in breast cancer.

Thirty-seven (4.1%) cases of nodal metastases skipping the first level are reported in a consecutive series of 912 breast cancer axillary dissections including 392 N+ cases. First level nodes examination is sufficiently accurate in assessing the quality of nodal status (negative or positive) but not the extent of nodal involvement (number of involved nodes).

Axilla↗
PubMed1985

Early detection of breast cancer recurrences through periodic follow-up--is it useless?

The authors report on a multicentric consecutive series of 1120 breast cancer first recurrences. Cases detected as subjectively asymptomatic thanks to periodic follow-up examinations are compared to cases detected as symptomatic. The relapse-free interval from primary treatment was shorter for asymptomatic recurrences, confirming that an earlier diagnosis was achieved in these cases. In spite of this diagnostic anticipation, median and actuarial survival from primary treatment did not differ when asymptomatic recurrences were compared to symptomatic recurrences. The study results did not show any prognostic impact of periodic follow-up in breast cancer and urge for prospective controlled studies on this diffuse and expensive practice.

Breast Neoplasms↗
PubMed1985

Staging breast cancer--screening for occult metastases.

The authors report on 1,017 consecutive breast cancer cases without symptomatic metastases staged by means of chest X-ray (CXR), skeletal survey (BXR) and bone scintigraphy (BS). Occult metastases (DM) detection rate was 0.88%: 0.29% for lung and 0.59% for bone DM. The detection rate was correlated with clinical stage: 0.36% for stage I, 0.20% for stage II, 0.26% for stages I and II, and 2.77% for stage III cases. The sensitivity based on DM cases prevalent or surfacing within 6 months of follow-up was 0.30 for CXR, 0.22 for BXR and 0.55 for BS; specificity was 0.99, 0.98 and 0.90, respectively. The study confirms the possibility of early detection of DM with preoperative staging, but the extremely low detection rates in stage I and II cancers do not advise such a routine procedure. The higher detection rate of DM may suggest adoption of the routine staging procedure in stage III cancers. In these cases, although no evidence is available of a favorable prognostic impact of early detection and treatment of DM, an unnecessary mastectomy could be avoided in about 3% of cases in the presence of DM detected by the staging procedure.

Age Factors↗
PubMed1984

Early detection of local recurrences in the follow-up of primary breast cancer.

The results of physical examination (PE) in the detection of local recurrences (LR) from breast cancer are reviewed in the follow-up experience of 1139 breast cancer patients. A minimum follow-up time of 5 years was considered. LR accounted for 40% of total first relapses and isolated (without distant metastases) LR represented about 1/3 of total relapses. The chest wall was the most frequent site of LR. The extent of LR was correlated with the probability of associated distant metastases detectable at the time of LR diagnosis, whereas no correlations were found with the presence or absence of subjective symptoms at diagnosis. The mean free interval from primary surgery was 3 months shorter for LR detected in asymptomatic phase than in the symptomatic phase. This difference increased to 5 months for recurrences detected in the first 2 years, when PE controls were repeated every 6 months whereas a smaller difference of 2 months was observed over 2 years with yearly controls. The mean and 5-year actuarial survival was better (75.5 vs. 64.9 months and 54% vs. 40%) for cases detected in the asymptomatic phase than in the symptomatic phase; however, the difference was not statistically significant for the small sample considered and could be even partially due to length biased sampling. On the basis of the reported results, PE should still be recommended as a follow-up test, although further studies are needed to assess its real impact on prognosis.

Breast Neoplasms↗
PubMed1984

Further SEM observation of human scalp hair: statistical research.

Scalp hair of 100 somalian subjects (50 males and 50 females) were examined with SEM at standard magnification (X 1.000). On each specimen, the hair diameter, mean scale height (M.S.H.), scale index (S.I.), mean scale number (M.S.N.) and mean scale width (M.S.W.) were searched. The statistical elaboration of the obtained data indicates that: i) the hair diameter and M.S.N. are greater in the males, while the other parameters (M.S.H., M.S.W. and S.I.) are prevalent in the females; ii) the hair diameter is directly correlated with M.S.W. and M.S.N., while M.S.H. shows a direct correlation with M.S.W. and an inverse on with M.S.N.. From the comparison between these results and those previously obtained in 100 subjects of white race it results that: a) the mean hair diameter as well as M.S.W. are greater in the white subjects; b) M.S.N., M.S.H. and S.I. are prevalent in the somalians.

Adult↗
PubMed1984

Respiratory function tests after mantle irradiation in patients with Hodgkin's disease.

Pulmonary function tests were performed in 43 patients with Hodgkin's disease before mantle irradiation and at 3, 6, 9, 12 and 15 or more months thereafter. Treatment was given with a telecobalt unit to a total dose of 36 to 42 Gy, the higher dose being reserved for cases with considerable mediastinal involvement. The functional parameters explored included static and dynamic lung volumes, gas exchanges, ventilatory efficiency, and airway resistance. Measured parameters were expressed as a percentage of the pre-treatment value (PTV) in the individual patient. In the whole group, only small variations in the functional indices were observed at 3 to 6 months after mantle irradiation. In patients with normal PTVs a greater variation in static and dynamic volumes was observed at 3 to 6 months after mantle irradiation, with complete recovery thereafter. The gas exchange parameters also showed a similar variation at 3 to 6 months but no recovery was demonstrated in the subsequent examinations. No changes in ventilatory efficiency and airway resistance were observed. In patients with abnormal PTVs, usually presenting large mediastinal adenopathy, all parameters improved after mantle irradiation, and the favourable effect of tumour regression was probably more important than the radiation damage on the pulmonary parenchyma.

Adolescent↗
PubMed1983

[Statistical findings on scalp hair as observed by scanning electron microscopy].

The scalp hair of hundred, 20-year-old, healthy human blond and dark volunteers (50 males and 50 females) have been studied by means of scanning electron microscopy. On the photographs, taken at right angles to the length of the hair and always at the same magnification, some measurements have been performed: 1) the hair diameter, 2) the mean scale height, 3) the mean scale number, 4) the scale index and 5) the mean scale width. The obtained data were submitted to a statistical elaboration which gave the following results: a) the hair diameter and the cuticular scale patterns do not show statistically significant differences between males and females and blond and dark subjects; b) an inverse correlation exists between the height and the number of the scales; c) the hair diameter is correlated inversely with the mean scale height and directly with the mean scale number and width.

Adult↗
PubMed1983

The value and limitations of the CO2 laser in neurosurgery.

A report is made of 42 patients operated on by the 100 W CO2 laser from May 1979 to May 1980 and the effects of the continuous and pulsed emission of the beam are discussed. The usefulness of the Laser-microscope coupling is also reported. One estimates the average amount of blood transfused during and soon after the operation and this is compared with blood transfused in 42 patients operated by a 50 W CO2 laser and 42 patients operated by traditional techniques. The authors have been using the CO2 laser routinely since May 1977. Its use has been sometimes useful, sometimes very useful or indispensable, sometimes useless and/or dangerous.

Adenoma↗
PubMed1982

Radiation therapy of recurrences of carcinoma of the rectum and sigmoid after surgery.

Loco-regional recurrences are the most common type of postsurgical relapse of rectal and sigmoid carcinoma. The authors report on 108 consecutively treated patients: site, clinical features and symptoms of the recurrences are considered together with treatment results. A symptomatic effect was generally achieved with 35 to 45 Gy, while higher doses did not improve the response. Due to the high frequency of simultaneous involvement of perineum and true pelvis the authors recommend irradiation of both regions. Palliation is the sole aim in most cases. However, curative treatment can be attempted in single perineal recurrences.

Adult↗