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Biomedical subjects

P Netter

Publications and source records attributed to P Netter.

At least 415 records · Page 23Linked to original sources
PubMedDate not supplied

The diagnostic value of 99m Tc-diphosphonate bone imaging in transient osteoporosis of the hip.

We present topographic and quantitative studies of 99m Tc-diphosphonate bone scans from 46 patients and 25 control subjects in which we found transient osteoporosis of the hip (TOH) (12 cases--2 bilateral), early aseptic osteonecrosis of the femoral head (19 cases--2 bilateral), early coxitis (11 cases), and stress fracture of the femoral neck (4 cases). Active TOH was characterized by intense, homogeneous increased uptake of the entire femoral head, extending to the acetabulum and the neck, and sometimes to the shaft. The scintigram of TOH differed greatly from that in the other hip disorders studied. Bone scintigraphy can help to diagnose the cause of pain in a hip before definite roentgenographic signs appear.

Adult↗
PubMedDate not supplied

[Toxicity and pharmacokinetics of zirconium oxychloride in mice and rats].

The experimental toxicity of zirconium compounds is examined in the Mouse (acute toxicity) and in the Rat (short time toxicity). The absorption, the distribution and the elimination of zirconium are evaluated by zirconium cation assay in some biological fluids and tissues. After a single oral dose, zirconium oxyd is not toxic, zirconium oxychlorure slightly toxic and zirconium chlorure moderately toxic. At certain concentrations, cerebral and pulmonary disorders are observed, particularly with zirconium chlorure. In considering molar toxicity, the studied zirconium compounds are more toxic than certain aluminium salts mentioned in the literature. The zirconium oxychlorure doesn't influence the growth curve after iterative administrations (0.23 g zirconium/kg/day). Only a weak fraction of administered zirconium is absorbed and is electively fixed in the ovaries, in a lesser degree in the lung and the bone. In the ovary the zirconium induces vascular variation (hypervascularization) which appear one month after the end of the treatment. The absorbed zirconium is eliminated by the urinary tract. The fecal elimination can be essentially explained by an important quantity of non absorbed zirconium.

Animals↗
PubMedDate not supplied

Osteomalacia, pseudosacroiliitis and necrosis of the femoral heads in Fanconi syndrome in an adult.

The symptom of bone pain led to the discovery of Fanconi syndrome in a 20-yr-old patient. The presenting osteomalacia was associated with an early deterioration of the sacroiliac joint and osteonecrosis of both femoral heads. The coexistence of these 2 unusual disorders was not coincidental. A diagnosis of osteomalacia was considered because of impaired mineralization predominantly affecting the median part of the sacroiliac joints. The bone necroses, of probable microfracture origin, were probably directly related to the osteomalacia.

Adult↗
PubMedDate not supplied

[Extraskeletal uptake in bone scintigraphy].

Interpretation of a bone scan requires perfect knowledge not only of normal appearances and of the various methods of expression of bony lesions but also of normal or pathological extra-skeletal uptakes which can : (1) be a source of interpretation owing to their superposition with a bony segment. (2) provide useful further information directly linked to the bony disorder studied. (3) permits the unexpected discovery of lesions of the soft tissues. A careful clinical examination of the patient, and knowledge of the whole of the history permits one to explain most of the scanning abnormalities observed.

Bone and Bones↗