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Biomedical subjects

P Moullot

Publications and source records attributed to P Moullot.

24 records · Page 2Linked to original sources
PubMed1981

[T lymphocytes functions in mercuric chloride-induced membranous glomerulonephritis in man. Evidence for a defect of presentation of the histocompatibility class II molecules at the cell surface (author's transl)].

Membranous glomerulonephritis (MGN) is one of the well documented manifestations of autoimmunity during chronic mercuric chloride (HgCl2) intoxication. We have carried out immunological investigation of the T cell functions in a patient presenting an HgC12-induced MGN. Circulating auto-antibodies and immune complexes were absent from the serum. Lymphocyte transformation with HgCl2 over a wide range of doses (10(-3) to 10(-8) M) was negative. E rosettes, mitogen reactivity, allogeneic reactivity evidenced by a one way mixed lymphocyte culture gave slightly diminished results. These findings contrasted with a severe impairment of the stimulative ability of lymphocytes. This defect might be related to the inability of D, DR products to be exposed at the cell surface and impeding the allogeneic recognition by foreign lymphocytes. This lymphocyte defect in the course of an HgC12 MGN in man would be correlated with lymphocyte abnormalities found in experimental HgC12-treated rats. The results of this study would favour the hypothesis of a direct role of HgC12 on lymphocyte rather than a direct action on glomerular basement membrane.

Adult↗
PubMedDate not supplied

[Acute pancreatitis complicating biliary distomatosis caused by Fasciola hepatica in a patient with a choledochal diverticulum].

A 43 years old man presented with acute pancreatitis following 13 years of mild grade hepatic colitis and angiocholitis. The absence of visible gall stone evocated the possibility of millithiasis. The operation discovered a big and hard head of the pancreas and an hypertrophied choledocal mucous membrane and the microscopic analysis of bladder's bile, ova of Fasciola hepatica. A control opacification on the 7th day revealed an adult fluke and a small diverticulum which were not visible on the roentgenogram at the time of the operation. Seven infusions of 60 mg de dehydroemetin permitted to eliminate the fluke with only a peak of fever. The diagnostic, pathophysiologic and therapeutic implications are discussed.

Acute Disease↗