Safety of upper gastrointestinal endoscopy with intravenous sedation by the endoscopist at office: 17,963 examinations performed in a community center by two endoscopists over 17 years.
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Biomedical subjects
Publications and source records attributed to P Moullot.
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Plethoryl is a combination of triatricol, cyclovalone and vitamin A normally prescribed in the treatment of hypercholesterolaemia. Four cases of side-effects most probably caused by this product are reported. They include: 1) a case of common acute hepatitis, 23 cases of which have already been published, with aggravation and reduced time-lapse after reintroduction; 2) a case of clinically silent but biochemically classical hepatitis; 3) a case of cirrhosis due to vitamin A toxicity; 4) a case of inflammatory arthralgias recurring after the same time-lag when the drug was reintroduced despite double doses and without clinical evidence of hepatitis. The last three side-effects have never been previously reported. The adverse reactions to Plethoryl almost always occur in the unofficial indications of the product, notably in the "treatment" of obesity.
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A 77 years old man has been treated by roentgenotherapy for an epidermoid carcinoma of the esophagus. The lesion extended from 24 to 37 cm of the arcades and did not modify roentgenographically the contraction of the muscular layer. This cancer has been heralded by inhalations when swallowing. An error of focusing of radiotherapy resulted in an under irradiation of the upper segment of the esophagus. At the same level a recurrency of the lesions has been treated by electrocoagulation under fibroscopy. The palliation was good but it did not prevent multiple recurrences. The remainder of the esophagus which received 60 Grays has been cured during the three years of follow-up. A second patient has a asymptomatic microcarcinoma at 32 cm. seemingly superficial and was cured by 60 Grays after a follow-up of seven years. External roentgenotherapy is compared to surgery and the use of local treatments as electrocoagulation, laser therapy and intraluminal roentgentherapy are discussed.
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Four patients with acute colonic pseudo-obstruction were treated by colonoscopic aspiration. This treatment proved sufficient in 1 case due to Salmonella colitis and 1 case of parkinsonian dysautonomia. It has made it possible to diagnose a pyocholecyst masked by the colonic dilatation it had provoked, and facilitated its surgical treatment. A transient result was obtained in a case of otherwise asymptomatic choleperitoneum. Colonoscopy was relatively easy, perfectly well tolerated and always useful. It is therefore recommended for the treatment of acute colonic pseudo-obstruction except in cryptogenic colitis where its effectiveness and safety have not been demonstrated.
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