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Biomedical subjects

P Moron

Publications and source records attributed to P Moron.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Plasma amino acid disturbances and depression].

Plasmatic amino acids concentrations were measured in 59 depressive patients and compared with that of a control population. Serine, glutamine, cystine, lysine and arginine have increased levels in the depressed males and females; so are 3 competitors of the tryptophan for the transport through the blood-brain barrier: valine, leucine and isoleucine. The tryptophan ratio is decreased in the depressive males. The sum of the competitors of the tryptophan is increased in the depressive males and females. All these results are discussed in relation with an abnormality of the carrier through the blood-brain barrier in the depressive state, without no proof thereof being however given.

Adult↗
PubMedDate not supplied

[Efficacy of verapamil in mania crises].

The authors review the different studies on the use of calcium antagonists in the treatment of acute mania. They present 7 cases, of which 4 with manic-depressive psychosis and 3 with schizo-affective disorder, during acute mania as defined by DSM III criteria, treated by verapamil at the dose of 320 mg/day. Four patients improved (2 manic-depressive, 2 schizo-affective), of which one that had responded neither to haloperidol nor to clonidine, and another for which all other treatment was contra-indicated due to important side effects. Three of these patients entered into acute depressive state between the 12th and the 15th day of treatment. The two most severe (manic-depressive) cases did not respond. The role of calcium in neuron physiology and the mode of action of calcium antagonists are outlined. The authors discuss the physiopathological hypothesis of Dubovsky.

Acute Disease↗