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Biomedical subjects

P Moron

Publications and source records attributed to P Moron.

At least 37 records · Page 2Linked to original sources
PubMed1985

Treatment of childhood and adolescent depression with mianserin.

The efficacy of mianserin in treating adult depression is now well established. Since there are no publications concerning the use of mianserin in children, the authors set up an open pilot study of 110 depressed children and adolescents aged 8-19 years. The average dose of mianserin was 1 mg/kg/day. Efficacy of treatment was noticeable by the end of the first week and was maintained throughout the 60 day study period. Evaluation was based on both clinical observations and changes in scores obtained from 80 subjects. Side-effects were minimal leading to temporary withdrawal of treatment in only seven cases. The profile of mianserin in children and adolescents is similar to that of adults. It is an antidepressant with an anxiolytic component, and has a regulating effect on sleep. In view of its efficacy, compliance, and the very low incidence of side-effects, mianserin appears to be a useful treatment for depression in children and adolescents. The results of this open study justify the development of further controlled studies.

Adolescent↗
PubMed1984

[Hematopoietic changes in states of severe malnutrition in anorexia nervosa].

This work, studying the effects of severe caloric deficiency on the medullary activity, shows that, in anorexia nervosa, there are some modifications of the stem cells, in particular in the granulocyte line and that its rarefaction is proportional to the intensity of denutrition. The reduction of the stock of stem cells, for which two hypotheses have been raised, could be a factor of vulnerability to infections in these patients in case of severe denutrition.

Adolescent↗
PubMed1983

[Biologic diagnosis of depression by the TRH and dexamethasone tests].

Nowadays the diagnosis of depression can be made through two neuroendocrine tests, which tend to become common: the TRH test and the Dexamethasone Suppression Test which have a wide diagnostic accuracy. Any abnormal finding could implicate a dysfunction of neurotransmitter systems. They are of diagnostic assistance in endogenous depressions supposed to be responsive to antidepressants. They might also be a practical monitor of treatment response since the test results reverting to normal seems to indicate recovery whereas persisting abnormal results are a possible predictor of relapse.

Adrenocorticotropic Hormone↗