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Biomedical subjects

P Montgomery

Publications and source records attributed to P Montgomery.

At least 73 records · Page 4Linked to original sources
PubMed1989

Inflammatory cell infiltrate in distal ureteral segments from patients with reflux.

A total of 110 reimplanted ureters from 61 patients were examined by light microscopy. Twenty-four distal segments from nonrefluxing ureters were used as control group. Overall, 55 of 110 specimens (50%) had inflammatory cell infiltrates (ICI) consisting of lymphocytes and plasma cells in the submucosa and adjacent muscularis. Forty-five ureters (82%) had mild ICI, and 10 ureters (18%) had moderate or severe ICI only in patients with history of infection. ICI increased with grade of reflux in both infected and noninfected groups. Of 75 ureters (68%) from patients with history of infection, 45 (60%) had ICI. Ten of 35 ureters (29%) from patients without history of infection had ICI. A causal relationship between reflux and ICI remains speculative and needs further study.

Adolescent↗
PubMed1988

Pathological and toxicological studies of calves fed a high concentration cotton seed meal diet.

Feeding a high concentration of cotton seed meal to young calves resulted in death with lesions compatible with gossypol toxicity. Calves were fed two different commercially prepared rations. Free gossypol concentrations in different lots of the 17% protein ration varied from 250 to 380 ppm, and the 13% protein ration varied from 40 to 240 ppm. Serum sorbitol dehydrogenase elevation was the most consistent clinical pathological finding. The mean serum sorbitol dehydrogenase concentrations for moribund, hospitalized, and clinically healthy calves were 277, 34, and 45 units/liter. The mean for sorbitol dehydrogenase concentration for healthy calves not fed cotton seed meal was 18 units/liter. Gross lesions included severe effusion of a high protein content fluid into the body cavities of most calves, edema of the mesentery, and hepatomegaly. The most consistent histological lesion was severe centrilobular hepatic necrosis. Elevated levels of liver gossypol were demonstrated. The mean liver gossypol concentration for three calves was 41.7 micrograms/g on a wet weight basis.

Animal Feed↗
PubMed1987

Brain adenosine receptors in Maudsley reactive and non-reactive rats.

Previous work in our laboratory has shown that the Maudsley reactive (MR) strain of rats cannot be differentiated from the Maudsley non-reactive (MNR) strain regarding the number or affinity of their brain benzodiazepine binding sites. In the present study we show that the number of cerebellar adenosine receptors (as studied using [3H]cyclohexyladenosine, [3H]CHA, as the ligand) are increased by 15-30% in the MR strain. This alteration was corroborated by quantitative autoradiographic analysis and found to be localized to the molecular layer of the cerebellum where adenosine receptors are believed to reside on parallel fibers of cerebellar granule cells.

Adenosine↗
PubMed1987

CT evaluation of severe renal inflammatory disease in children.

We have performed CT scans on 15 children and 2 young adults with severe renal inflammatory disease. Most children with urinary tract infections do not require such evaluation. We have, however, found CT helpful in defining the nature of renal abnormality and in defining the extent of disease in selected patients who either presented as diagnostic dilemmas or who did not respond initially to proper medical treatment. We therefore use CT scanning as our initial examination in such problem patients.

Adolescent↗
PubMed1987

Computerized tomography and acute pyelonephritis in children. A clinical correlation.

The clinical records and computerized tomography (CT) scans of 14 patients who presented with pyelonephritis to the Children's Hospital of Buffalo between 1976-1985 have been reviewed. The CT findings were as follows: multifocal pyelonephritis (6), lobar nephronia (6), focal pyelonephritis (2). All patients were treated with intravenous antibiotics, and none was surgically drained. Significant underlying diseases were present in 8 patients: diabetes (6), von Gierke disease (1), hepatorenal syndrome (1). The diabetic children tended to have focal disease. Ten voiding cystourethrograms were performed and only four demonstrated reflux. All children became afebrile within a few days. Lobar nephronia was as clinically responsive as pyelonephritis to antibiotic therapy. Urine cultures were most often positive, although there was 1 patient in each category with negative cultures. Blood cultures were rarely positive in any group. Gram negative organisms predominated. CT scanning in children with clinical acute pyelonephritis reveals three major imaging patterns. While distinct radiographically, they behave in a similar clinical manner. Lobar nephronia does not imply a worse clinical prognosis. Intravenous antibiotic therapy alone was adequate for all patients.

Child↗
PubMed1987

Persistent upregulation of brain adenosine receptors in response to chronic carbamazepine treatment.

Chronic carbamazepine treatment for a period of 2 weeks caused a highly significant increase in brain adenosine receptors in the rat. The carbamazepine was administered in food pellets in a diet that achieved clinically relevant total plasma concentrations of carbamazepine and its active-10,11-epoxide metabolite. Of the several brain areas examined, the cerebral cortex and hippocampus exhibited the most robust increases in [3H]cyclohexyladenosine (CHA) binding. Increases of 35-40% were observed in these brain regions whereas an 8-10% increase was seen in the cerebellum. The carbamazepine induced increase in brain adenosine receptors in all these areas persisted unabated at 1 and 5 days as well as 2, 4, and 8 weeks following termination of carbamazepine treatment, suggesting a relatively permanent alteration of the adenosine receptor by this drug.

Adenosine↗
PubMed1987

Ontogenetic profile of the adenosine uptake sites in rat forebrain.

The ontogenesis of rat forebrain adenosine uptake sites labelled by [3H]nitrobenzylthioinosine ([3H]NBI) was determined and compared to that of rat forebrain adenosine receptors labelled by N6-cyclohexyl[3H]adenosine ([3H]-CHA). [3H]NBI binding is highly invariant with similar levels of [3H]NBI binding sites from embryonic day 19 to day 30 postpartum. Scatchard and Hill analyses reveal the binding of [3H]NBI in 6-day-old tissue to be indistinguishable from such binding in 30-day-old tissue. In contrast, [3H]-CHA binding is highly variant. [3H]CHA binding develops slowly but steadily from about embryonic day 19, with adult binding levels being achieved at around 25 days postpartum. The ontogenetic profile of [3H]CHA appears to coincide with synaptogenesis whereas that of [3H]NBI does not.

Adenosine↗
PubMed1987

Health care utilization in the years prior to death.

The impact of an aging population on the health care system is a primary speculative concern for health policy. Unique data from a large sample of 4,263 decedents aged 45 years and over in Manitoba, Canada, describe actual utilization in the four years prior to death: all hospitalizations, nursing home stays, and ambulatory physician contacts. Total expenditures associated with dying do increase with age, but even among the very elderly many deaths have few expenditure consequences. Apocalyptic scenarios for the health care system may be premature.

Aged↗
PubMed1985

De Barsy syndrome--an autosomal recessive, progeroid syndrome.

We report two families with seven siblings with de Barsy syndrome. Characteristic features include severe mental retardation, hypermobility with athetoid movements, grimacing, muscular hypotonia, laxity of small joints and brisk deep tendon reflexes, progeroid aspect with cutis laxa, atrophy of skin with hyperpigmentation, isolated depigmentations, reduction of subcutaneous fatty tissue, translucent vein pattern, short stature, frontal bossing in the young child, large prominent ears with dysplastic helices and corneal clouding or cataracts. The syndrome probably has autosomal recessive inheritance.

Abnormalities, Multiple↗
PubMed1985

Rhabdoid tumor of the kidney: a case report.

Rhabdoid tumor of the kidney may simulate other pediatric renal tumors radiographically but it has a characteristic clinical course with a high incidence of intracranial tumors. This clinical course and its implications for prognosis and radiographic work-up are discussed.

Brain Neoplasms↗
PubMed1984

Multifocal nephroblastomatosis: clinical significance and imaging.

The correlation between nephroblastomatosis and Wilms' tumor has been established in the pathology literature. Two cases of multifocal nephroblastomatosis in the kidney contralateral to a Wilms' tumor are presented. The importance of these lesions and their recognition is discussed.

Child, Preschool↗
PubMed1984

Macular electroretinograms: their accuracy, specificity and implementation for clinical use.

The pattern and the focal electroretinogram (ERG) are both non-invasive, electrophysiological responses recorded from circumscribed retinal areas and are most easily recorded from the macula. This paper describes how our department has incorporated these tests into our clinical protocol, shows how the recording technique and the method of electrode construction may be improved, and describes the normal limits of the macular responses we obtain. The ERG signal-noise ratio we obtained was better than that of the binocular visual evoked potentials (VEPs) recorded simultaneously. Pattern and focal ERGs, using improved methods of recording, show promise of being a valuable addition to the clinical investigation of subtle maculopathies and some forms of optic nerve dysfunction. Three illustrative cases are described. The first demonstrates normal macular ERG responses with abnormal Ganzfeld ERGs due to peripheral retinal damage. The second reveals differential pattern ERG reduction with normal focal ERG in recent optic neuritis. The third case demonstrates reversible simultaneous loss of Ganzfeld ERGs and macular ERGs in vitamin A deficiency.

Adult↗
PubMed1982

Hodgkin's disease in a community oncology center: ten years' experience.

A total of 77 cases of Hodgkin's disease have been evaluated and the patients treated at our institution during the past ten years. Advances in diagnostic technology and therapy have improved the outcome of the disease and overall survival. Therapy during this period has not been standardized. Radiation therapy was the primary initial treatment for stages I, II and III, with combined-modality therapy or chemotherapy alone used for more advanced stages. Five-year disease-free and overall survival for stage IA is 81 percent and 95 percent, respectively; 74 percent and 78 percent for stage IIA; 70 percent in both instances for stage IIB; 54 percent and 100 percent for stage IIIA; 75 percent and 100 percent for stage IIIB, and 57 percent and 69 percent for stage IV. Of 13 patients initially treated with chemotherapy, 77 percent have had a complete response. Of the 16 patients (88 percent) having a relapse, 14 have been salvaged with a variety of therapeutic approaches. Overall, five-year survival for 77 patients is 86 percent, with 70 percent having no relapse.

Adolescent↗