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Biomedical subjects

P Mattes

Publications and source records attributed to P Mattes.

44 records · Page 3Linked to original sources
PubMed1976

[Influence of somatostatin (GIF) and human gastrin I on the lower esophageal sphincter].

The influence of gastrin and somatostatin on the lower esophageal sphincter was investigated in 10 metabolically healthy volunteers and one patient with Zollinger-Ellison syndrome. It could be shown that only unphysiologically high concentrations of gastrin produced a rise in pressure in the lower esophageal sphincter, while somatostatin has neither an effect on the lower esophageal sphincter pressure, nor is it able to inhibit the pharmacologic effect of exogeneous gastrin administration. The results emphasize that gastrin and somatostatin have no influence on the tone of the lower esophageal sphincter.

Esophagogastric Junction↗
PubMed1975

Extended somatostatin treatment of a patient with bleeding ulcer.

The results of a 67 hour cyclic somatostatin continuous infusion in a patient with a bleeding ulcer are reported. The subject was a 65 year old male with very heavy gastrointestinal bleeding on the 9th postoperative day following a high BI-resection. Endoscopy revealed the bleeding to be caused by two residual ulcers in the area of the anastomosis. Somatostatin treatment led to an immediate cessation of the bleeding after 1 hour. Gastric secretion as well as gastrin, insulin and growth hormone levels were significantly inhibited by somatostatin. Endoscopy at the end of the treatment period showed two ulcers in the process of healing. The raised blood glucose levels caused by somatostatin were easily controlled with max. 14 IU cristalline insulin daily. Except for dryness in the mouth, no adverse side effects were apparent. There was no evidence from laboratory investigations of hemostatic defects or bleeding tendency in the patient.

Aged↗
PubMed1975

[Construction of a neoesophagus using lyophilized dura. Animal experiment in dogs].

The experiments have proven the feasibility of bridging short oesophageal defects as well as longer ones with lyophilized dura. By means of a two-stage-operation respectively a combined homologous-alloplastik oesophageal prosthesis the risk of insufficiency of anastomoses may be minimized. Thus its clinical application seems worthy of consideration.

Animals↗