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Biomedical subjects

P Mattes

Publications and source records attributed to P Mattes.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Modified cardiomyotomy using Rapant's method - guaranteed prevention of esophageal reflux in the operative therapy of achalasia?].

13 patients of 23 who had been treated for achalasia by a modified esophagomyotomy were reexamined by objective assessment of esophageal function with special regard to the problems mentioned above. Pull-through-manometry displayed a decrease of resting tonicity from 37 to 8 mm Hg. In the reflux-provocation-test all patients had a normal test result. In endoscopy normal histological findings raised 70% preoperatively to 83% postoperatively. The esophageal diameter was reduced in 11 of 13 patients. No patient had symptoms to suggest the presence of reflux and relapse.

Esophageal Achalasia↗
PubMed1979

A model for duodeno-gastric reflux.

Electric stimulation of the duodenum can produce duodeno-gastric reflux. The functionability of this model was examined by intraluminal manometry, bromsulphtaline reflux and duodenal electrogram.

Animals↗
PubMed1979

[Gastroesophageal reflux: a factor eliciting esophageal variceal hemorrhage?].

Following a hemorrhage, ten patients with esophageal varices were examined by means of gastroscopy and functional analysis of the esophagus with special regard to gastroesophageal reflux. A pathological gastroesophageal reflux was not confirmed. These results plus previously published findings lead to the assumption that reflux is of not importance in the initiation of esophageal variceal bleeding.

Adolescent↗
PubMed1979

[Is there a characteristic constellation of findings in esophageal functional diagnosis after antireflux operations?].

The significance of the finding esophagitis (grade I) in 23 patients was evaluated by manometry, measurement of pH and acid clearance test 18 months after the antireflux procedure (Lortat-Jacob). The provocation of pathological reflux was impossible (reflux provocation test). The acid clearance test demonstrated a low grade delay of the emptying rate. From these results it is supposed that the antiflux procedure only produces a pressure barrier but not a digestive sphincter. According to the pressure barrier in the functional analysis of the esophagus, three typical findings appeared: esophagitis (grade I), normal pH-monitoring, and delayed acid clearance.

Biopsy↗
PubMed1979

[Cryosurgery in the treatment of Echinococcus alveolaris. Animal experiments].

The influence of cryosurgery on echinococcus alveolaris is studied in 100 mice. In a second series cryosurgical effects on structures of the hepatic portal (hepatic artery, portal vein, hepatic duct) were examined. The experiments showed that echinococcus alveolaris can be devitalized by cryosurgical measures at temperatures between -100 degrees C and -190 degrees C. No damage of the hepatic artery, portal vein, and hepatic duct occurred. Clinical application of cryosurgery for the treatment of inoperable echinococcus alveolaris of the hepatic portal appears to be justified.

Animals↗
PubMed1979

[Esophageal myoplicature in the treatment of decompensated achalasia].

Heller's cardiomyotomy or one of the modifications are not sufficient in the third stage of achalasia. Additional surgery is required for reversion of the dilated and elongated esophagus. Two patients with third-grade achalasia were treated by cardiomyotomy in combined with esophagomyoplication and followed up for one year. The results were evaluated clinically, radiologically, manometrically, pH-metrically, and endoscopically. We concluded that esophagomyoplication satisfactorily completes cardiomyotomy in cases of third-grade achalasia.

Cardia↗
PubMed1977

[Esophageal replacement with lyophilized dura (author's transl)].

In 50 dogs thoracic or cervical esophagus was resected and the defect was replaced by a prosthesis made out of lyophilized dura. The healing process was studied radiologically and by clinical and histological examination. The experiments have proved the feasibility of bridging esophageal defects with lyophilized dura. The dura is replaced within 2 months by a tube of connective tissue. Until epithelialisation is complete there is a tendency to circular contraction. A stenosis could be prevented by dilatation or by means of a homologous-alloplastic esophageal prosthesis.

Animals↗
PubMed1977

Effect of dopamine in stress ulcer of rats.

The effect of dopamine in stress-induced ulceration of stomach mucosa employing a hypoxia-immobilisation stress, was investigated in rats. Intravenous administration of small doses of dopamine (3 mug/kg body weight/min) significantly lowered the development of mucosa erosions. A bilious reflux which was observed after dopamine infusion but not in controls may be considered as a side effect of this agent.

Animals↗
PubMed1977

Effects of somatostatin and human gastrin I on the lower esophageal sphincter in man.

The influence of gastrin and somatostatin on the lower esophageal sphincter was investigated in a total of ten metabolically healthy volunteers and one patient with Zollinger-Ellison syndrome. It could be shown that only unphysiologically high concentrations of gastrin produce a rise in pressure in the lower esophageal sphincter, while somatostatin has neither an effect on the lower esophageal sphincter pressure, nor is it able to inhibit the pharmacological effect of exogenic gastrin administration. The results of this study demonstrate that normal levels of serum gastrin do not seem to have much effect of resting LES pressure, nor does somatostatin. (Gastrin, in fact, in pharmacologic dosage does have an effecton the tonicity of the lower esophageal sphincter.)

Adult↗
PubMed1976

Prevention of stress ulcer by somatostatin in rats.

In animal experiments it was examined, to what extent prophylactic application of Somatostatin is able to prevent the stress-induced ulcer of the rat. 32 male Wistar rats were exposed to a combined immobilisation-hypoxia-stress. Somatostatin was given intraperitoneally as bolus and intravenously as a continuous infusion. The results indicated that Somatostatin lowers significantly the incidence rate of stress-induced gastric ulcers in the rat.

Animals↗
PubMed1976

[Therapeutic problems of autonomous adenoma of the thryroid (author's transl)].

Radioiodine therapy and surgical enucleation as a functionally legitimate operation are adequate methods of treatment for the autonomous adenoma of the thyroid. With reference to a series of our own patients, the making of the indication, the operation technique and the carrying out of radioiodine therapy are commented on. The aim of the operation is the enucleation of the autonomous adenoma without traumatizing the healthy thyroid tissue and without ligature of the polar vessels. The aim of radioiodine therapy is the selective destruction of the adenoma. The indication for the operation should certainly be made more liberally to perform the low-risk enucleation.

Adenoma↗